Anti-obesity Effects of the Administration of Tournefortia paniculata Cham Extract on Wistar Rats Subjected to a Hypercaloric Diet

Simão, Anderson Assaid; Ramos, Vinicius de Oliveira; Corrêa, Angelita Duarte; Sousa, Raimundo Vicente de

doi:10.1590/s1516-8913201500075

Cited by 3 publications

(2 citation statements)

References 19 publications

(17 reference statements)

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“…In addition, the aqueous extract of leaves from Tournefortia paniculata Cham., rich in phenolic compounds (Simão et al 2014) presented in vitro inhibition of the α-amylase and α-glycosidase enzymes before and after exposure to gastric fluid simulation (Simão et al 2012), and later, when administered to Wistar rats submitted to high calorie diet resulted in weight, food intake, liver fat, glucose and serum triglycerides reduction (Simão et al 2015). The results described by these authors highlights the resistance of inhibitors present in P. guajava leaves to go through simulated gastric fluid, there is maintenance of inhibitory action in vivo.…”

Section: Resultsmentioning

confidence: 99%

Aqueous extract of Psidium guajava leaves: phenolic compounds and inhibitory potential on digestive enzymes

Simão

Marques

Marcussi

et al. 2017

An. Acad. Bras. Ciênc.

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Leaves of Psidium guajava L. (guava) have been widely used in the popular way for prevention and treatment of various diseases. Thus, the objective of this study was to evaluate the inhibitory potential of leaves aqueous extract from three cultivars of P. guajava (Pedro Sato, Paluma and Século XXI) on α-amylase, α-glycosidase, lipase, and trypsin enzymes, in the presence or not of simulated gastric fluid and to determine the content of phenolic compounds by high performance liquid chromatography. All cultivars presented the same composition in phenolic compounds, but in different proportions. The compounds identified are gallic acid, epigallocatechin gallate, syringic acid, o-coumaric acid, resveratrol, quercetin, and catechin (which was the major compound in all the cultivars evaluated). In the absence of simulated gastric fluid, it was observed different inhibitions exercised by the leaves aqueous extracts from three cultivars of P. guajava on each enzyme. In presence of simulated gastric fluid, all cultivars showed increase in the inhibition of lipase and α-glycosidase, and decrease in inhibition of α-amylase and trypsin enzymes. These results indicate that P. guajava leaves aqueous extracts from all cultivars evaluated possess potential of use as an adjuvant in the treatment of obesity and other dyslipidemias.

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Section: Resultsmentioning

confidence: 99%

Aqueous extract of Psidium guajava leaves: phenolic compounds and inhibitory potential on digestive enzymes

Simão

Marques

Marcussi

et al. 2017

An. Acad. Bras. Ciênc.

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“…Lipid peroxidation was determined by the formation of substances that react with thiobarbituric acid (TBARS), according to Simão, Ramos, Corrêa, Sousa, and Marcussi (2015). TBARS concentration was calculated from the malonyldialdehyde standard curve-MDA (1,1,3,3 tetraethoxypropane).…”

Section: Lipid Peroxidationmentioning

confidence: 99%

Antioxidant activity and hepatoprotective potential of lyophilized extract of acerola bagasse against CCl ₄ ‐induced hepatotoxicity in Wistar rats

et al. 2018

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The current study evaluated the antioxidant and hepatoprotective potential of the lyophilized extract of acerola bagasse (EAB), which is a residue from the processing of the fruit (rich in phenolic compounds), against the toxic action of carbon tetrachloride (CCl4) in Wistar rats. The rats were divided into six groups of six animals and received the treatments by gavage once a day, for 21 days. The treatments with EAB containing 7 and 14 mg of phenolic compounds/kg animal weight (AW) presented a decrease in the activity of aspartate aminotransferase, alanine aminotransferase and gamma glutamyl transferase, and an increase in superoxide dismutase, total antioxidant capacity and albumin content in relation to treatment with water and CCl4. It is concluded that the EAB has antioxidant and hepatoprotective action, at doses of 7 and 14 mg of phenolic compounds/kg AW, with possible applications in pharmaceutical, cosmetics, and food industries. Practical application Agro‐industrial wastes are promising sources of phytochemicals beneficial to health, as the phenolic compounds. Phenolic compounds prevent the action of reactive species in the human body, as well as the onset of various diseases. In this study, extract of acerola bagasse possess antioxidant and hepatoprotective actions due to the presence of phenolic compounds. The extract was able to reduce the levels of alanine aminotransferase, aspartate aminotransferase, and gamma glutamyl transferase and increase in total antioxidant levels in plasma. Thus, the acerola bagasse is a source phenolic compounds, whose extract might be able to fight reactive oxygen and nitrogen species.

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Herbal Medicines for the Management of Obesity

Kılıç

2023

Role of Herbal Medicines

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Anti-obesity Effects of the Administration of Tournefortia paniculata Cham Extract on Wistar Rats Subjected to a Hypercaloric Diet

Abstract: ABSTRACT

Cited by 3 publications

References 19 publications

Aqueous extract of Psidium guajava leaves: phenolic compounds and inhibitory potential on digestive enzymes

Aqueous extract of Psidium guajava leaves: phenolic compounds and inhibitory potential on digestive enzymes

Antioxidant activity and hepatoprotective potential of lyophilized extract of acerola bagasse against CCl ₄ ‐induced hepatotoxicity in Wistar rats

Herbal Medicines for the Management of Obesity

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Anti-obesity Effects of the Administration of Tournefortia paniculata Cham Extract on Wistar Rats Subjected to a Hypercaloric Diet

Abstract: ABSTRACT

Cited by 3 publications

References 19 publications

Aqueous extract of Psidium guajava leaves: phenolic compounds and inhibitory potential on digestive enzymes

Aqueous extract of Psidium guajava leaves: phenolic compounds and inhibitory potential on digestive enzymes

Antioxidant activity and hepatoprotective potential of lyophilized extract of acerola bagasse against CCl 4 ‐induced hepatotoxicity in Wistar rats

Herbal Medicines for the Management of Obesity

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Antioxidant activity and hepatoprotective potential of lyophilized extract of acerola bagasse against CCl ₄ ‐induced hepatotoxicity in Wistar rats