Anti-obesity effects of capsaicin and the underlying mechanisms: a review

Li, Run; Lan, Yaqi; Chen, Chengyu; Cao, Yong; Ho, Chi‐Tang; Lu, Muwen

doi:10.1039/d0fo01467b

Cited by 51 publications

(24 citation statements)

References 115 publications

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“…This is in line with previous in vivo and in vitro reports in different tissues. A study on obese mouse models demonstrated that capsaicin administration promotes mitochondrial function and increased ATP levels in these animals [51]. Moreover, capsaicin appears to also increase glucose metabolism and ATP production in the human intestinal epithelium [10,52].…”

Section: Discussionmentioning

confidence: 99%

TRPV1 Activation by Capsaicin Mediates Glucose Oxidation and ATP Production Independent of Insulin Signalling in Mouse Skeletal Muscle Cells

Ferdowsi

Ahuja

Beckett

et al. 2021

Cells

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Background: Insulin resistance (IR), a key characteristic of type 2 diabetes (T2DM), is manifested by decreased insulin-stimulated glucose transport in target tissues. Emerging research has highlighted transient receptor potential cation channel subfamily V member (TRPV1) activation by capsaicin as a potential therapeutic target for these conditions. However, there are limited data on the effects of capsaicin on cell signalling molecules involved in glucose uptake. Methods: C2C12 cells were cultured and differentiated to acquire the myotube phenotype. The activation status of signalling molecules involved in glucose metabolism, including 5’ adenosine monophosphate-activated protein kinase (AMPK), calcium/calmodulin-dependent protein kinase 2 (CAMKK2), extracellular signal-regulated protein kinases 1 and 2 (ERK1/2), protein kinase B (AKT), and src homology phosphatase 2 (SHP2), was examined. Finally, activation of CAMKK2 and AMPK, and glucose oxidation and ATP levels were measured in capsaicin-treated cells in the presence or absence of TRPV1 antagonist (SB-452533). Results: Capsaicin activated cell signalling molecules including CAMKK2 and AMPK leading to increased glucose oxidation and ATP generation independent of insulin in the differentiated C2C12 cells. Pharmacological inhibition of TRPV1 diminished the activation of CAMKK2 and AMPK as well as glucose oxidation and ATP production. Moreover, we observed an inhibitory effect of capsaicin in the phosphorylation of ERK1/2 in the mouse myotubes. Conclusion: Our data show that capsaicin-mediated stimulation of TRPV1 in differentiated C2C12 cells leads to activation of CAMKK2 and AMPK, and increased glucose oxidation which is concomitant with an elevation in intracellular ATP level. Further studies of the effect of TRPV1 channel activation by capsaicin on glucose metabolism could provide novel therapeutic utility for the management of IR and T2DM.

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Section: Discussionmentioning

confidence: 99%

TRPV1 Activation by Capsaicin Mediates Glucose Oxidation and ATP Production Independent of Insulin Signalling in Mouse Skeletal Muscle Cells

Ferdowsi

Ahuja

Beckett

et al. 2021

Cells

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“…The beneficial effects of capsaicin consumption on the maintenance of a healthy body weight and reduction of adipose tissue have also been observed (Sharma et al, 2013). Preclinical and clinical studies have shown that the potential mechanism of capsaicin's anti-obesity action includes the inhibition of adipogenesis, activation of brown adipose tissue (BAT) and stimulation of thermogenesis, increased lipolysis, decreased appetite, and increased satiety as a result of the regulation of the nervous system in the hypothalamus and modulation of the functions of the digestive system and the intestinal microbiome (Li et al, 2020b;Rosca et al, 2020;Zheng et al, 2017). The main mechanism of action of capsaicin on the metabolism is the activation of TRPV1 (transient receptor potential vanilloid subfamily 1).…”

Section: Capsaicinmentioning

confidence: 99%

“…Randomized clinical trials have shown an association between increased capsaicin intake in the diet and decreased appetite, increased resting energy expenditure, increased fat oxidation, increased BAT activity, and increased thermogenesis (Zheng et al, 2017). In obese subjects, an increase in capsaicin consumption was associated with a decrease in blood glucose, a decrease in tissue insulin resistance, and a favorable lipid profile (Li et al, 2020b). In studies on mice, following the administration of capsaicin, a favorable change in the intestinal microbiota was observed, consisting in the growth of bacteria that synthesize short-chain fatty acids (SCFA) and a reduction in the number of gram-negative bacteria producing LPS (bacterial liposaccharide), which increases the production of pro-inflammatory cytokines (Wang et al, 2020b).…”

Section: Capsaicinmentioning

confidence: 99%

Dietary supplements in therapy to support weight reduction in obese patients [pdf]

Wawrzyniak¹,

Skrypnik²,

Suliburska³

2022

Acta Sci Pol Technol Aliment

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Obesity is a pandemic disease that poses a serious problem for the entire world population. Preventative and non-pharmacological treatments for obesity include changing eating habits and increasing physical activity. The use of certain dietary supplements also brings beneficial results in the process of reducing excess body weight. There are many options for the treatment of obesity available on the pharmaceutical market. This study aims to review the latest publications on selected dietary supplements in the treatment of excess body weight. Dietary supplements which support a reduction in excess body weight include capsaicin, bitter orange, white bean seeds, green coffee, berberine, and single and multi-strain probiotics. Some of these supplements have additional health benefits. Bitter orange has antioxidant and anti-ulcer properties. Berberine improves lipid metabolism and reduces blood glucose levels. Capsaicin has found application in the treatment of neurodegenerative diseases. Supplements that do not significantly reduce body weight are chitosan and vitamin D. Chitosan can reduce blood pressure, while vitamin D improves the sensitivity of tissue to insulin. An increase in body mass index (BMI) is associated with an increased risk of many diseases, including cardiovascular disease, diabetes mellitus, musculoskeletal disorders, and certain cancers. Dietary supplements with beneficial effects which support a reduction in excess body weight can be used in the treatment of both obesity and its complications.

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“…Recently, RK has attracted researchers' attention because of its weight‐control application. The motivation for these studies comes from the structural similarity of RK with capsaicin and synephrine, which are known to exert antiobesity effects (Li et al., 2020). In 2005, Morimoto (Morimoto et al., 2005) first elucidated the influence of RK on obesity and demonstrated that RK supplementation decreased body weight gain, hepatic triglyceride content, and the weight of visceral adipose tissue (epididymis, retroperitoneum, and mesentery) in high‐fat diet‐induced obese mice.…”

Section: Health Benefits Of Raspberry Ketonementioning

confidence: 99%

Potential metabolic activities of raspberry ketone

Xiao-ping

Wei

et al. 2021

Journal of Food Biochemistry

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Novel food and food compounds interventions have attracted a lot of attention nowadays for the prevention and treatment of metabolic diseases. Raspberry ketone (RK) is aromatic compound found within red fruits and berries, has been used as an over‐the‐counter product for weight loss. However, actually, the effect of RK on weight loss is still controversial, and the mechanism is largely unknown. Besides, in vivo and in vitro studies have demonstrated the beneficial effect of RK on the development of other metabolic diseases. In this review, we comprehensively highlighted the synthesis, bioavailability, and metabolism of RK, and summarized the progress made in our understanding of the potential biological activities of RK, including antiobesity, antidiabetes, cardioprotection, and hepatoprotection, as well as their underlying mechanisms. This paper provides a critical overview about the current findings and proposes the future studies in the area of RK on human health. Practical applications Raspberry ketone (RK) has been used for weight control for years, but this effect is controversial considering food intake. Additionally, RK is beneficial for T2DM, liver and heart injury. The underlying mechanisms of the protective effect of RK including accelerating fatty acid oxidation, balancing serum glucose level, anti‐inflammation, antioxidant process, and so on. In this context, we provide a comprehensive analysis of the benefits of RK against many metabolic diseases and discuss the underlying molecular mechanisms. We hope our work will be helpful for further researches on RK and improve its public recognition.

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Anti-obesity effects of capsaicin and the underlying mechanisms: a review

Abstract: Obesity and overweight have become a serious health problem in the world, which are linked to a varity of metabolic disorders. Phytochemicals with weight-loss effect have been widely studied for...

Cited by 51 publications

References 115 publications

TRPV1 Activation by Capsaicin Mediates Glucose Oxidation and ATP Production Independent of Insulin Signalling in Mouse Skeletal Muscle Cells

TRPV1 Activation by Capsaicin Mediates Glucose Oxidation and ATP Production Independent of Insulin Signalling in Mouse Skeletal Muscle Cells

Dietary supplements in therapy to support weight reduction in obese patients [pdf]

Potential metabolic activities of raspberry ketone

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