Anti-Obesity Effect of<i>Allium hookeri</i>Leaf Extract in High-Fat Diet-Fed Mice

Park, Sung Yong; No, Kihoon; Lee, Joomin

doi:10.1089/jmf.2017.3962

Cited by 18 publications

(15 citation statements)

References 39 publications

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“…It has a variety of phenols such as protocatechuic acid, ferulic acid, gallic acid, and syringic acid and especially has high levels of sulfur-containing compounds such as alliin and cycloalliin compared to other Allium species [12,26]. AH has received considerable attention owing to its well-documented physiological activities [14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,32]. Our previous study has demonstrated that major components of AHR are alliin, S -allylcysteine, and phenolic compounds that are known to have anti-inflammatory [23,24,25] and antidiabetic effects [18,19,20].…”

Section: Discussionmentioning

confidence: 99%

“…However, uptake of excessive amounts of FFA by alteration of lipolysis in these tissues causes obesity and insulin resistance [41,42]. Regarding lipid metabolism, some studies have shown that AH has pronounced effects on obesity by down-regulating GLUT-4 in adipocytes and hepatic mRNA levels of FAS and LPL in diet-induced obese mice [21,22]. In this study, AHR decreased mRNA expression involved in hepatic lipogenesis and increased mRNA expression involved in adipogenesis and lipolysis in WAT, in spite of a reduction in weight and adipocyte size of WAT.…”

Section: Discussionmentioning

confidence: 99%

“…Beneficial effects of AH are attributed to a variety of phenols (ferulic acid, gallic acid and cinnamic acid), phytosterols, linoleic acid and organosulfur compounds [13]. AH is known to have biological properties, such as being antioxidant [14,15,16], antimicrobial [17], antidiabetic [18,19,20], anti-obesity [21,22], and anti-inflammatory [23,24,25], as well as hepatoprotective effects [26]. It can also improve bone formation [27], gastritis [28], and immune responses [29].…”

Section: Introductionmentioning

confidence: 99%

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Allium hookeri Root Extract Inhibits Adipogenesis by Promoting Lipolysis in High Fat Diet-Induced Obese Mice

Jang¹,

Lee²

2019

Nutrients

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Allium hookeri (AH) is widely consumed as a herbal medicine. It possesses biological activity against metabolic diseases. The objective of this study was to investigate effects of AH root water extract (AHR) on adipogenesis in 3T3-L1 cells and in high-fat diet (HFD)-induced obese mice. AHR inhibited lipid accumulation during adipocyte differentiation by downregulation of gene expression, such as hormone sensitive lipase (HSL), lipoprotein lipase (LPL) and an adipogenic gene, CCAAT/enhancer binding protein-α in 3T3-L1 preadipocytes. Oral administration of AHR significantly suppressed body weight gain, adipose tissue weight, serum leptin levels, and adipocyte cell size in HFD-induced obese mice. Moreover, AHR significantly decreased hepatic mRNA expression levels of cholesterol synthesis genes, such as 3-hydroxy-3-methylglutaryl CoA reductase, sterol regulatory element-binding transcription factor (SREBP)-2, and low-density lipoprotein receptor, as well as fatty acid synthesis genes, such as SREBP-1c and fatty acid synthase. Serum triglyceride levels were also lowered by AHR, likely as a result of the upregulating gene involved in fatty acid β-oxidation, carnitine palmitoyltransferase 1a, in the liver. AHR treatment activated gene expression of peroxisome proliferator-activated receptor-γ, which might have promoted HSL and LPL-medicated lipolysis, thereby reducing white adipose tissue weight. In conclusion, AHR treatment can improve metabolic alterations induced by HFD in mice by modifying expression levels of genes involved in adipogenesis, lipogenesis, and lipolysis in the white adipose tissue and liver.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Allium hookeri Root Extract Inhibits Adipogenesis by Promoting Lipolysis in High Fat Diet-Induced Obese Mice

Jang¹,

Lee²

2019

Nutrients

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“…The beneficial effects of this herb are attributed to the presence of various phenols (e.g., ferulic acid, gallic acid, and cinnamic acid), phytosterols, linoleic acid, and organosulfur compounds. Allium hookeri is known to have bioactive properties, such as antioxidant (Cho et al., 2015; Kim et al., 2016), antimicrobial (Lucchini et al., 2018; Poznanski et al., 2004), antidiabetic (Roh et al., 2016; Yang et al., 2016), anti‐obesity (Park et al., 2018), anti‐inflammatory (Schwendimann et al., 2020), and hepatoprotective effects (Kim et al., 2019; Park et al., 2018). Recently, A. hookeri extract was shown to decrease body weight and improve lipid profiles in rats fed a high‐fat diet (Jang et al., 2018; Kim et al., 2019).…”

Section: Introductionmentioning

confidence: 99%

Effects of Gouda cheese and Allium hookeri on thermogenesis in mice

Kim

Lee

Yoo

et al. 2021

Food Science & Nutrition

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Cheese contains various beneficial nutrients, including calcium and whey protein, as well as large amounts of saturated fatty acids. Thus, intake of cheese increases the production of low‐density lipoprotein‐cholesterol (LDL‐C), a well‐defined risk factor for cardiovascular disease. Therefore, identification of natural products that inhibit LDL‐C production following cheese intake and verification of the efficacy of such products in animal models are essential. Here, we evaluated the effects of Allium hookeri, a well‐known traditional herbal remedy, on metabolism and thermogenesis in mice consuming a cheese‐containing diet. Intake of A. hookeri extracts significantly blocked increases in body weight and fat mass caused by intake of Gouda cheese in mice. Additionally, increases in blood triglyceride levels following intake of Gouda cheese were alleviated by A. hookeri. Moreover, intake of Gouda cheese enhanced thermogenesis efficiency. Thus, A. hookeri may have applications as an important additive for reducing the risk of metabolic disease resulting from cheese consumption.

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“…A. hookeri was listed on the Plant List based on database of World Checklist of Selected Plant Families in 2012 (http:// www.theplantlist.org). A. hookeri has been reported to have anti-inflammatory [6], anti-obesity [7], osteoblastic [8], anti-oxidant [9], and anti-diabetic [9] activities. However, these effects were observed in animal studies.…”

Section: Introductionmentioning

confidence: 99%

A randomized, double-blind, placebo-controlled crossover clinical trial to evaluate the anti-diabetic effects of Allium hookeri extract in the subjects with prediabetes

Park

Bae

Choi

et al. 2020

BMC Complement Med Ther

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Background Allium hookeri is widely consumed as a vegetable and herbal medicine in Asia. A. hookeri has been reported anti-inflammatory, anti-obesity, osteoblastic, anti-oxidant, and anti-diabetic effects in animal studies. We investigated the anti-diabetic effects of A. hookeri aqueous extract (AHE) in the Korean subjects. Methods Prediabetic subjects (100 ≤ fasting plasma glucose (FPG) < 126 mg/dL) who met the inclusion criteria were recruited for this study. The enrolled subjects (n = 30) were randomly divided into either an AHE (n = 15, 486 mg/day) or placebo (n = 15) group. Outcomes were measurements of FPG, glycemic response to an oral glucose tolerance test (OGTT), insulin, C-peptide, hemoglobin A1c (HbA1c), total cholesterol, triglyceride, HDL-cholesterol, and LDL-cholesterol. The t-test was used to assess differences between the groups. A p-value < 0.05 was considered statistically significant. Results Eight weeks after AHE supplementation, HbA1c level was significantly decreased in the AHE group compared with the placebo group. No clinically significant changes in any safety parameter were observed. Conclusion The findings suggest that AHE can be effective in reducing HbA1c, indicating it as an adjunctive tool for improving glycemic control. Trial registration The study protocol was retrospectively registered at www.clinicaltrials.gov (NCT03330366, October 30, 2017).

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Anti-Obesity Effect ofAllium hookeriLeaf Extract in High-Fat Diet-Fed Mice

Cited by 18 publications

References 39 publications

Allium hookeri Root Extract Inhibits Adipogenesis by Promoting Lipolysis in High Fat Diet-Induced Obese Mice

Allium hookeri Root Extract Inhibits Adipogenesis by Promoting Lipolysis in High Fat Diet-Induced Obese Mice

Effects of Gouda cheese and Allium hookeri on thermogenesis in mice

A randomized, double-blind, placebo-controlled crossover clinical trial to evaluate the anti-diabetic effects of Allium hookeri extract in the subjects with prediabetes

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