Anti-obesity effect of hibiscus Sabdariffal.- a review

L, Anna Sheba; Ilakkia, A

doi:10.22376/ijpbs.2016.7.4.b341-345

Cited by 5 publications

(2 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…6 Moreover, some of the currently available anti-obesity pharmaceutical drugs are subject to being abuse, 7 expensive with severe side effects, and not suitable for usage for a long period. 8 New insight into the management of obesity involves the use of phenolic compounds. This is due to their ability to attenuate inflammation, drug resistance, and angiogenesis.…”

Section: Introductionmentioning

confidence: 99%

<p>Urolithins Attenuate Multiple Symptoms of Obesity in Rats Fed on a High-Fat Diet</p>

Abdulrahman

Kuerban

Alshehri

et al. 2020

DMSO

View full text Add to dashboard Cite

Background: Urolithins are gut microbiota-derived polyphenol metabolites, produced following the consumption of pomegranate, berries, and nuts. Recent studies have shown the potentials of these metabolites on reducing triglycerides accumulation in cultured hepatocytes and adipocytes. In this study, we investigated the ability of both urolithin A (Uro-A) and urolithin B (Uro-B) to attenuate obesity and associated symptoms in a high-fat diet-induced obesity model in rats. Methods: Twenty-four male Wistar rats were randomly assigned to four groups. Group 1 was fed on a normal diet while groups 2, 3, and 4 were fed on a high-fat diet for 10 weeks. After this, groups 3 and 4 were treated with 2.5mg/kg body weight of Uro-A and Uro-B intraperitoneally, respectively. Body weight, serum lipid profile, hepatic antioxidant activity, hepatic lipid accumulation, fecal lipid content, and the expressions of genes involved in lipogenesis and hepatic ER stress were quantified. Results: Indeed, a high-fat diet resulted in increased body weight, visceral adipose tissue mass, and oxidative stress in rats. However, treatment with both Uro-A and Uro-B decreased body weight and visceral adipose tissue mass. These metabolites restored hepatic antioxidant capacity and decreased lipid accumulation in addition to an increase in fecal fat excretion. Moreover, both Uro-A and Uro-B treatment downregulated the expression of LXRα and SREBP1c; involved in de novo lipogenesis while upregulating PPARα expression for increased fatty acid oxidation. Furthermore, Uro-A and Uro-B decreased the expression of PERK and IRE1α; which are involved in hepatic ER stress. Taken together, our results showed the potentials of Uro-A and Uro-B in mitigating obesity symptoms and they could thus provide promising roles in the future as functional anti-obesity candidates.

show abstract

Section: Introductionmentioning

confidence: 99%

<p>Urolithins Attenuate Multiple Symptoms of Obesity in Rats Fed on a High-Fat Diet</p>

Abdulrahman

Kuerban

Alshehri

et al. 2020

DMSO

View full text Add to dashboard Cite

show abstract

“…Furthermore, it exhibits extensive antibacterial properties. Its purplish sepals (calyx and epicalyx) rich in anthocyanin are used economically in food (Jam and Jelly) and cosmetic industries as a source of natural coloring agent [19].…”

Section: Introductionmentioning

confidence: 99%

A Study on Phytochemicals, Antimicrobial, and Synergistic Antimicrobial Activities of Hibiscus Sabdariffa

Kumar¹,

L²

2019

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objective: The aim of the present study was to screen phytochemical constituents and evaluate antimicrobial and synergistic antimicrobial properties of leaves and stem of Hibiscus sabdariffa. Methods: The extraction was done by cold maceration method using 80% aqueous methanol. The antimicrobial efficacy and synergistic antimicrobial activity were carried out by disc diffusion assay against the bacteria Staphylococcus aureus and Pseudomonas aeruginosa. Results: Phytochemical analysis revealed the presence of carbohydrate, protein, alkaloids, phytosterols, flavonoids, and diterpenes in both the leaves and stem extracts while saponins, phenol, and tannins were found to be present only in the leaf extract. Both the extracts inhibited the tested bacteria with minimum inhibitory concentration value of 10 mg/ml. Aqueous methanolic extract of leaf showed higher antibacterial activity against S. aureus and P. aeruginosa and also exhibited synergistic activity with the antibiotic chloramphenicol against S. aureus. Conclusion: The present study concludes that H. sabdariffa is a potential source of bioactive components and also provides information on synergistic activity of leaf extract. The results can contribute to the development of potent antibacterial agents.

show abstract

Effects of culinary herbs and spices on obesity: A systematic literature review of clinical trials

Deekshith

Jois

Radcliffe

et al. 2021

Journal of Functional Foods

View full text Add to dashboard Cite

Anti-obesity effect of hibiscus Sabdariffal.- a review

Cited by 5 publications

References 30 publications

<p>Urolithins Attenuate Multiple Symptoms of Obesity in Rats Fed on a High-Fat Diet</p>

<p>Urolithins Attenuate Multiple Symptoms of Obesity in Rats Fed on a High-Fat Diet</p>

A Study on Phytochemicals, Antimicrobial, and Synergistic Antimicrobial Activities of Hibiscus Sabdariffa

Effects of culinary herbs and spices on obesity: A systematic literature review of clinical trials

Contact Info

Product

Resources

About