Anti-obesity effect of carboxymethyl chitin by AMPK and aquaporin-7 pathways in 3T3-L1 adipocytes

Supplementation of Chitosan Alleviates High-Fat Diet-Enhanced Lipogenesis in Rats via Adenosine Monophosphate (AMP)-Activated Protein Kinase Activation and Inhibition of Lipogenesis-Associated Genes

“…Recent studies have suggested that the derivatives of chitin and chitosan (carboxymethyl chitin and chitosan oligosaccharides) exert the antiobesity effect on blocking lipid accumulation and inhibition of adipocyte differentiation via AMPK activation in 3T3-L1 adipocytes. 44,45 We further found that administration of a chitosan-supplemented diet, especially supplementation of 7% chitosan, was resistant to HF-dietinduced obesity and fat accumulation in the liver accompanying AMPK activation and suppressive expression of lipogenic transcription factors and lipogenesis-associated genes. On the other hand, leptin is an adipocyte-secreted hormone in proportion to white adipose mass.…”

Anti-HIV-1 activity of phlorotannin derivative 8,4‴-dieckol from Korean brown alga Ecklonia cava

“…9,10) In addition, several natural products from marine organisms have been reported to express bioactivity against prevalent diseases such as cancer, diabetes, and obesity. [11][12][13] So far, numerous compounds isolated from natural resources have been reported to exhibit significant anti-HIV activity and inhibit HIV-1 activity in almost every stage of the viral life cycle. 14) Polysaccharides and phlorotannins isolated from the marine algae show distinct inhibitory activity against HIV-1 reproduction as well as viral infection.…”

Sodium acetate decreases phosphorylation of hormone sensitive lipase in isoproterenol-stimulated 3T3-L1 mature adipocytes

“…15 Other studies have shown that activation of G protein-coupled receptors present in the cell membrane of adipocytes results in a reduction in the lipolytic rate as determined by the release of NEFA and/or glycerol. 14,[28][29][30][31] In this study we have demonstrated that incubating mature 3T3-L1 adipocytes with supra-physiological levels of sodium acetate also reduces the rate of lipolysis, as measured by the rate of NEFA release, although glycerol release appeared to remain unaffected in the presence of sodium acetate. These data agree with previous reports showing changes in lipolysis, expressed as a reduction in the level of glycerol and/or NEFA release, in the presence of ligands of G protein-coupled receptors containing a small carboxylic acid tail region 32,33 similar to that of sodium acetate.…”