Anti-HIV-1 activity of phlorotannin derivative 8,4‴-dieckol from Korean brown alga <i>Ecklonia cava</i>

Karadeniz, Fatih; Kang, Kyong‐Hwa; Park, Jae W.; Park, Sunjoo; Kim, Se‐Kwon

doi:10.1080/09168451.2014.923282

Cited by 45 publications

(33 citation statements)

References 32 publications

(30 reference statements)

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“…Natural seaweed products have demonstrated low levels of cytotoxicity (Karadeniz et al, 2014) -even lower than commercial drugs such as AZT (Barbosa et al, 2004). The toxicity of A. spicifera extracts has already been studied in mice (Naqvi et al, 1980) and Vero cell line (Duarte et al, 2004).…”

Section: Resultsmentioning

confidence: 99%

Anti-HIV-1 activity in human primary cells and Anti-HIV-1 RT inhibitory activity of extracts from the red seaweed Acanthophora spicifera

Nogueira¹,

PaixÃ£o²,

Cirne-Santos³

et al. 2016

J. Med. Plants Res.

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First generation drugs such as zidovudine have been extensively used in clinical practice, resulting in the development of HIV resistance to these nucleoside analogs. Several studies have demonstrated the effective anti-HIV activity of natural products derived from seaweeds, suggesting promising sources of substances for the development of novel antiviral drugs. In this paper, the antiviral effect of extracts from the red seaweed Acanthophora spicifera on HIV-1 replication was evaluated in vitro. Peripheral blood mononuclear cells obtained using the Ficoll-Hypaque gradient were used for cytotoxicity and antiviral activity testing. The dichloromethane extracts, ethyl acetate, acetone, and methanol were found to have CC 50 values of 31±7.4, 45±11, 38±3.5, and 179±25 µg/mL, respectively. With the control, the extract prepared in ethyl acetate inhibited approximately 60% of the viral load, which is the best result among the extracts. This same extract showed an IC 50 value of 33.17±4.84 μg/mL for the reverse transcriptase. The EtOAc extract from A. spicifera showed to be an efficient HIV antiviral due to its phenolic compounds, as evaluated by nuclear magnetic resonance.

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Section: Resultsmentioning

confidence: 99%

Anti-HIV-1 activity in human primary cells and Anti-HIV-1 RT inhibitory activity of extracts from the red seaweed Acanthophora spicifera

Nogueira¹,

PaixÃ£o²,

Cirne-Santos³

et al. 2016

J. Med. Plants Res.

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“…Drug-resistant strains of the intracellular pathogen Mycobacterium tuberculosis have stimulated a search for novel drug leads with novel mechanisms of action, and, as shown in Table 1 and Figure 1, five novel marine natural products (108)(109)(110)(111)(112) isolated from sponges and fungi evidenced promising activity, and thus contributed to the ongoing global search for novel antituberculosis agents during 2014-2015.…”

Section: Antiprotozoal and Antituberculosis Activitymentioning

confidence: 99%

“…that demonstrated strong inhibitory activity against M. smegmatis in "both active growing and dormancy-inducing hypoxic conditions" [104]. Daletos and colleagues isolated cyclic peptides callyaerins A and B (109,110), from the Indonesian sponge Callyspongia aerizusa, that demonstrated potent antibacterial activity against M. tuberculosis, highlighting the "potential of these compounds as promising anti-TB agents" [105]. Kumar and colleagues established that a new diarylpyrrole alkaloid denigrin C (111) from an extract of the Indian marine sponge Dendrilla nigra exhibited strong M. tuberculosis H 37 Rv activity "with a probable novel mechanism needed for antitubercular drug design .…”

Section: Antiprotozoal and Antituberculosis Activitymentioning

confidence: 99%

Marine Pharmacology in 2014–2015: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, Antiviral, and Anthelmintic Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

et al. 2019

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The systematic review of the marine pharmacology literature from 2014 to 2015 was completed in a manner consistent with the 1998–2013 reviews of this series. Research in marine pharmacology during 2014–2015, which was reported by investigators in 43 countries, described novel findings on the preclinical pharmacology of 301 marine compounds. These observations included antibacterial, antifungal, antiprotozoal, antituberculosis, antiviral, and anthelmintic pharmacological activities for 133 marine natural products, 85 marine compounds with antidiabetic, and anti-inflammatory activities, as well as those that affected the immune and nervous system, and 83 marine compounds that displayed miscellaneous mechanisms of action, and may probably contribute to novel pharmacological classes upon further research. Thus, in 2014–2015, the preclinical marine natural product pharmacology pipeline provided novel pharmacology as well as new lead compounds for the clinical marine pharmaceutical pipeline, and thus continued to contribute to ongoing global research for alternative therapeutic approaches to many disease categories.

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“…Furthermore, it selectively inhibited the activity of HIV-1 reverse transcriptase enzyme with 91% inhibition at 50 lM. Therefore, it showed high potential and could be considered as a drug candidate for the development of a new generation of therapeutic agents (Karadeniz et al 2014).…”

Section: Anti-hiv Activitymentioning

confidence: 99%

Recent advances in pharmacological research on Ecklonia species: a review

2017

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The genus Ecklonia (Lessoniaceae, Phaeophyceae), commonly called kelp (brown algae), is abundant on the coasts of Japan and Korea. During the past few decades, Ecklonia species have received tremendous attention for their wide range of therapeutic properties and multiple health benefits, such as great nutritional value and being rich in vitamins, minerals, dietary fiber, proteins, and polysaccharides. Several novel functional ingredients with diversified biological activities have been isolated and possess antimicrobial, antiviral, hepatoprotective, cardioprotective, anti-inflammatory, neuroprotective, anticarcinogenic, immunomodulatory, hypolipidemic, anti-diabetic, and antioxidant therapeutic properties. The present review discusses the phytochemical, pharmacological, therapeutic, nutritional, and health benefits of different species of genus Ecklonia, as well as their use in the prevention of disease and maintenance of good health.

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Anti-HIV-1 activity of phlorotannin derivative 8,4‴-dieckol from Korean brown alga Ecklonia cava

Cited by 45 publications

References 32 publications

Anti-HIV-1 activity in human primary cells and Anti-HIV-1 RT inhibitory activity of extracts from the red seaweed Acanthophora spicifera

Anti-HIV-1 activity in human primary cells and Anti-HIV-1 RT inhibitory activity of extracts from the red seaweed Acanthophora spicifera

Marine Pharmacology in 2014–2015: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, Antiviral, and Anthelmintic Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

Recent advances in pharmacological research on Ecklonia species: a review

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