Anti-obesity effect of a hop-derived prenylflavonoid isoxanthohumol in a high-fat diet-induced obese mouse model

Fukizawa, Shinya; Yamashita, Masakazu; Wakabayashi, Kenichi; Fujisaka, Shiho; Tobe, Kazuyuki; Nonaka, Yasuki; Murayama, Norihito

doi:10.12938/bmfh.2019-040

Cited by 12 publications

(12 citation statements)

References 32 publications

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“…[ 16–21 ] XN suppresses HFD‐induced body weight increase, the accumulation of fat in adipose tissue, and insulin resistance, while XN readily isomerizes to isoxanthohumol (IX). [ 22–25 ] The IMB biotransforms XN into 8‐prenylnaringenin (8‐PN) and dihydroxanthohumol (DXN), which both possess anti‐obesogenic properties. [ 26–28 ] Furthermore, XN possesses antimicrobial activity against anaerobic pathogens B. fragilis , C. perfringens , and C. difficile , and recent evidence indicates XN alters IMB composition, perhaps through its action as a protonophore.…”

Section: Introductionmentioning

confidence: 99%

“…[ 30 ] Furthermore, the protonophore IX affects alpha‐ and beta‐diversity and changes IMB composition. [ 24,25,33,34 ] Given the importance of the IMB in the development of diet‐induced obesity (DIO), and changes in IMB composition observed with XN supplementation, we hypothesize the IMB is required for XN to ameliorate metabolic symptoms associated with DIO.…”

Section: Introductionmentioning

confidence: 99%

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Xanthohumol Requires the Intestinal Microbiota to Improve Glucose Metabolism in Diet‐Induced Obese Mice

Logan

Shulzhenko²,

Sharpton

et al. 2021

Molecular Nutrition Food Res

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Scope The polyphenol xanthohumol (XN) improves dysfunctional glucose and lipid metabolism in diet‐induced obesity animal models. Because XN changes intestinal microbiota composition, the study hypothesizes that XN requires the microbiota to mediate its benefits. Methods and Results To test the hypothesis, the study feeds conventional and germ‐free male Swiss Webster mice either a low‐fat diet (LFD, 10% fat derived calories), a high‐fat diet (HFD, 60% fat derived calories), or a high‐fat diet supplemented with XN at 60 mg kg−1 body weight per day (HXN) for 10 weeks, and measure parameters of glucose and lipid metabolism. In conventional mice, the study discovers XN supplementation decreases plasma insulin concentrations and improves Homeostatic Model Assessment of Insulin Resistance (HOMA‐IR). In germ‐free mice, XN supplementation fails to improve these outcomes. Fecal sample 16S rRNA gene sequencing analysis suggests XN supplementation changes microbial composition and dramatically alters the predicted functional capacity of the intestinal microbiota. Furthermore, the intestinal microbiota metabolizes XN into bioactive compounds, including dihydroxanthohumol (DXN), an anti‐obesogenic compound with improved bioavailability. Conclusion XN requires the intestinal microbiota to mediate its benefits, which involves complex diet‐host‐microbiota interactions with changes in both microbial composition and functional capacity. The study results warrant future metagenomic studies which will provide insight into complex microbe‐microbe interactions and diet‐host‐microbiota interactions.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Xanthohumol Requires the Intestinal Microbiota to Improve Glucose Metabolism in Diet‐Induced Obese Mice

Logan

Shulzhenko²,

Sharpton

et al. 2021

Molecular Nutrition Food Res

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“…For example, an increased abundance of S24-7 resulting from supplementation with dietary fibre was strongly correlated with a suppression of inflammatory markers in obese mice (Serino et al 2012), and co-treatment of quercetin and resveratrol suppressed HFD-induced obesity with an accompanying increase in the intestinal population of S24-7 (Zhao et al 2017). Additionally, a lower abundance of Oscillospira in the intestine was observed for mice fed an HFD supplemented with flaxseed (Yang et al 2020) or isoxanthohumol (Fukizawa et al 2020), both of which have anti-obesity effects. Akkermansia is a mucin-degrading bacterium, and the anti-obesity effect of apple procyanidins was found to accompany an increased population of Akkermansia in the intestines of mice (Masumoto et al 2016).…”

Section: Discussionmentioning

confidence: 99%

“… 2020 ) or isoxanthohumol (Fukizawa et al . 2020 ), both of which have anti‐obesity effects. Akkermansia is a mucin‐degrading bacterium, and the anti‐obesity effect of apple procyanidins was found to accompany an increased population of Akkermansia in the intestines of mice (Masumoto et al .…”

Section: Discussionmentioning

confidence: 99%

Heat‐killed L actobacillus brevis KB290 attenuates visceral fat accumulation induced by high‐fat diet in mice

et al. 2021

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Aims: This study aimed to evaluate the anti-adiposity effect of heat-killed Lactobacillus brevis KB290 originating from traditional Japanese fermented pickles in mice fed a high-fat diet (HFD). Methods and Results: C57BL/6J mice were fed a normal-fat diet, HFD or HFD supplemented with heat-killed KB290 for 8 weeks. Epididymal and renal adipose tissue weights, as well as areas of epididymal adipocytes, were significantly lower in the mice fed a HFD supplemented with KB290 than in those fed an unsupplemented HFD. Mice whose diets were supplemented with KB290 had elevated adiponectin and b3-adrenergic receptor expression in epididymal adipose tissue and an accompanying higher serum free fatty acid level. Furthermore, the HFD-induced elevations in serum glucose, insulin and HOMA-IR were significantly suppressed by dietary supplementation with KB290. Amplicon sequencing of 16S rRNA genes revealed that KB290 ingestion altered the composition of the intestinal microbiota. Conclusions: Heat-killed L. brevis KB290 suppressed diet-induced visceral fat accumulation and ameliorated diet-induced metabolic symptoms and intestinal gut microbiota modifications, suggesting possibility of novel paraprobiotic. Significance and Impact of the Study: Heat-killed L. brevis KB290 is useable as a material to develop functional foods that attenuate visceral fat accumulation.

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“…The stimulation of IECs by rhubarb extract also might contribute to the increase in A. muciniphila (Neyrinck et al 2017). In other reports, flavonoids from apple (procyanidin) and hops (prenylflavonoids) could stimulate the growth of A. muciniphila leading to the improvement of metabolic syndrome (Fukizawa et al 2020;Hamm et al 2019;Masumoto et al 2016). Polyphenol derived from cranberry and green tea (synergistic effect with annatto-extracted tocotrienols) is also a key component in a diet that stimulates the growth of A. muciniphila (Anhê et al 2015;Elmassry et al 2020).…”

Section: Lactobacillusmentioning

confidence: 97%

The interaction of Akkermansia muciniphila with host-derived substances, bacteria and diets

Hagi

Belzer

2021

Appl Microbiol Biotechnol

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Trillions of microbes inhabit the human gut and build extremely complex communities. Gut microbes contribute to host metabolisms for better or worse and are widely studied and associated with health and disease. Akkermansia muciniphila is a gut microbiota member, which uses mucin as both carbon and nitrogen sources. Many studies on A. muciniphila have been conducted since this unique bacterium was first described in 2004. A. muciniphila can play an important role in our health because of its beneficial effects, such as improving type II diabetes and obesity and anti-inflammation. A. muciniphila establishes its position as a next-generation probiotic. Besides the effect of A. muciniphila on host health, a technique for boosting has been investigated. In this review, we show what factors can modulate the abundance of A. muciniphila focusing on the interaction with host-derived substances, other bacteria and diets. This review also refers to the possibility of the interaction between medicine and A. muciniphila; this will open up future treatment strategies that can increase A. muciniphila abundance in the gut. Key points • Host-derived substances such as bile, microRNA and melatonin as well as mucin have beneficial effects on A. muciniphila. • Gut and probiotic bacteria and diet ingredients such as carbohydrates and phytochemicals could boost the abundance of A. muciniphila. • Several medicines could affect the growth of A. muciniphila.

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Anti-obesity effect of a hop-derived prenylflavonoid isoxanthohumol in a high-fat diet-induced obese mouse model

Cited by 12 publications

References 32 publications

Xanthohumol Requires the Intestinal Microbiota to Improve Glucose Metabolism in Diet‐Induced Obese Mice

Xanthohumol Requires the Intestinal Microbiota to Improve Glucose Metabolism in Diet‐Induced Obese Mice

Heat‐killed L actobacillus brevis KB290 attenuates visceral fat accumulation induced by high‐fat diet in mice

The interaction of Akkermansia muciniphila with host-derived substances, bacteria and diets

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