Anti-Obesity Drug Orlistat (Xenical) Is a Novel Antitumor Medication

Azadbakht, Leila; Jamali-Gojani, Zahra; Heidari‐Beni, Motahar

doi:10.17795/semj26242

Cited by 10 publications

(9 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to a study by Greaves (2011) (30), micro vesicular fatty change is more likely a sign of toxicity while macro vesicular fatty change is related with metabolic abnormalities and is typically easily reversible. These findings are consistent with (31) which demonstrated that orlistat increased cell proliferation.…”

Section: The Results and Discussionsupporting

confidence: 91%

See 1 more Smart Citation

Comparative Physiology Study Of Side Effect Between Xenical And Lipo-6 Supplements Which Treated Obese Rabbets

Abdulshaheed

2022

Al-Qadisiyah Journal of Pure Science

View full text Add to dashboard Cite

Obesity is rapidly becoming a health problem, and it is considered a metabolic disease of epidemic proportions. Obesity is also associated with many comorbidities such as hyperlipidemia, fatty liver, atherosclerosis, cancer. Use of over-the-counter weight-loss supplements has become more common in the world; Xenical and Lipo-6 are two examples of nutritional supplements that do not pass safety research before being sold to the consumer. The ability of Xenical and lipo-6 supplements on DNA fragmentation in human lymphocytes was studied, where these cells represent important defense line of the body. On other hand, thirty white rabbits Iraqis in this experiment, weighing 2.5 to 3.0 kg were employed, which divided randomly to the three group (A: Control group, B: Xenical group, C: Lipo-6 group). In the end of experiment, all animals synthesized for collection blood to complete blood count examination and then all animal scarified for taking tissues samples to histopathological examination. The results showed that, the effects of two different types of medications on DNA fragmentation in human lymphocytes were examined. Xenical, at high concentrations (500 µg/ml), caused a significant fragmentation of lymphocytes' DNA (p ≥ 0.05); DNA fragmentation percentages were 68.5 percent after 24 hours and reached 76.4 percent after 48 hours. the lipo-6 at high concentration displayed apoptotic activity against healthy cells after 24 hours of exposure; DNA fragmentation was 80.13%. After 48 hours, the proportion of DNA fragmentation increased to 89.71 percent. As well as, the present study were conducting to determine toxicity of drug in rabbits in order to scientific information about its safety. The results of this study, reveals a histological sections for (liver, lung, heart, spleen, and intestine) in rabbits groups treated with Xenical and Lipo- 6 two capsule per day. pathological alterations in the treated rabbits' intestines, including macrophage and lymphocyte infiltration indicating chronic inflammation, furthermore, intestine section showed Macro vesicular fatty change. The spleen histological Samples founded with highly-blood foci (bleeding), highly infiltration with lymphocytes, also section exhibit highly proliferative cells with abnormal blood collections in both groups treated with Xenical and Lipo-6,in comparative to normal spleen. the lung tissue inflammation, the production of air vacuoles, damage to the alveolar sac and found a significant RBC cast in the heart muscle.

show abstract

Section: The Results and Discussionsupporting

confidence: 91%

“…These oxidizing substances deteriorate lumen membranes and speed up cell death. Leila and others, 2015 (31).…”

Section: Figure (3-6) Section Of Liver In Rabbits Treated With Xenica...mentioning

confidence: 97%

Comparative Physiology Study Of Side Effect Between Xenical And Lipo-6 Supplements Which Treated Obese Rabbets

Abdulshaheed

2022

Al-Qadisiyah Journal of Pure Science

View full text Add to dashboard Cite

show abstract

“…Aside from FASN inhibition, orlistat was also postulated to exert its antiproliferative effect via other mechanisms, such as induction of apoptosis, or reduction of proliferation rate due to direct toxicity and stimulation of intracellular accumulation of reactive oxygen species (34). However, our findings suggest that in the case of pancreatic cancer cells, reduced proliferation is a consequence of orlistat-mediated inhibition of FASN.…”

Section: Discussionmentioning

confidence: 60%

Orlistat Reduces Proliferation and Enhances Apoptosis in Human Pancreatic Cancer Cells (PANC-1)

Sokołowska

Presler

Goyke

et al. 2017

View full text Add to dashboard Cite

show abstract

“…HFD was widely employed to explore the pathophysiology of obesity and its related complications in view of its characteristics that closely mimic human obesity. Scientific evidence has demonstrated that orlistat exhibits a wide range of pharmacological activities, for example, anti-obesity [ 9 ], anti-inflammatory [ 15 ], and anti-tumour [ 16 ] activities, as well as improved oxidative stress status in the brain, renal, testis, and liver organs [ 17 , 18 , 19 ]. In our earlier studies, orlistat that was given to HFD-fed rats for 6 and 12 weeks, had shown to significantly improve the oxidant–antioxidant status in the heart and aorta tissues [ 11 , 13 ].…”

Section: Discussionmentioning

confidence: 99%

Orlistat Mitigates Oxidative Stress-Linked Myocardial Damage via NF-κβ- and Caspase-Dependent Activities in Obese Rats

Othman

Zakaria

Suleiman

et al. 2022

IJMS

View full text Add to dashboard Cite

Oxidative stress contributes to major complications of obesity. This study intended to identify whether orlistat could mitigate myocardial damage in obese animal models. The tested rats were divided into two groups and fed either with normal chow (n = 6 per group) or with a high-fat diet (HFD) for 6 weeks to induce obesity (n = 12 per group). Obese rats were further subjected to treatment either with distilled water (OB group) or orlistat 10 mg/kg/day (OB + OR group). Key indices of oxidative stress, inflammation, and apoptosis were assessed using an immunohistochemical-based technique and real-time PCR. The OB group showed significant increases of oxidative stress markers (TBARs and PCO), with significant decreases of anti-oxidant markers (Nrf2, SOD, CAT, and GPx). Furthermore, mRNA expression of pro-inflammatory markers (TNF-α and NF-κβ) and pro-apoptosis markers (Bax, Caspase-3, Caspase-8, and Caspase-9) were significantly upregulated in the OB group. Obese rats developed pathological changes of myocardial damages as evidenced by the presence of myocardial hypertrophy and inflammatory cells infiltration. Orlistat dampened the progression of myocardial damage in obese rats by ameliorating the oxidative stress, and by inhibiting NF-κβ pathway and caspase-dependent cell apoptosis. Our study proposed that orlistat could potentially mitigate oxidative stress-linked myocardial damage by mitigating inflammation and apoptosis, thus rationalizing its medical usage.

show abstract

Anti-Obesity Drug Orlistat (Xenical) Is a Novel Antitumor Medication

Cited by 10 publications

References 21 publications

Comparative Physiology Study Of Side Effect Between Xenical And Lipo-6 Supplements Which Treated Obese Rabbets

Comparative Physiology Study Of Side Effect Between Xenical And Lipo-6 Supplements Which Treated Obese Rabbets

Orlistat Reduces Proliferation and Enhances Apoptosis in Human Pancreatic Cancer Cells (PANC-1)

Orlistat Mitigates Oxidative Stress-Linked Myocardial Damage via NF-κβ- and Caspase-Dependent Activities in Obese Rats

Contact Info

Product

Resources

About