Obesity is rapidly becoming a health problem, and it is considered a metabolic disease of epidemic proportions. Obesity is also associated with many comorbidities such as hyperlipidemia, fatty liver, atherosclerosis, cancer. Use of over-the-counter weight-loss supplements has become more common in the world; Xenical and Lipo-6 are two examples of nutritional supplements that do not pass safety research before being sold to the consumer. The ability of Xenical and lipo-6 supplements on DNA fragmentation in human lymphocytes was studied, where these cells represent important defense line of the body. On other hand, thirty white rabbits Iraqis in this experiment, weighing 2.5 to 3.0 kg were employed, which divided randomly to the three group (A: Control group, B: Xenical group, C: Lipo-6 group). In the end of experiment, all animals synthesized for collection blood to complete blood count examination and then all animal scarified for taking tissues samples to histopathological examination. The results showed that, the effects of two different types of medications on DNA fragmentation in human lymphocytes were examined. Xenical, at high concentrations (500 µg/ml), caused a significant fragmentation of lymphocytes' DNA (p ≥ 0.05); DNA fragmentation percentages were 68.5 percent after 24 hours and reached 76.4 percent after 48 hours. the lipo-6 at high concentration displayed apoptotic activity against healthy cells after 24 hours of exposure; DNA fragmentation was 80.13%. After 48 hours, the proportion of DNA fragmentation increased to 89.71 percent. As well as, the present study were conducting to determine toxicity of drug in rabbits in order to scientific information about its safety. The results of this study, reveals a histological sections for (liver, lung, heart, spleen, and intestine) in rabbits groups treated with Xenical and Lipo- 6 two capsule per day. pathological alterations in the treated rabbits' intestines, including macrophage and lymphocyte infiltration indicating chronic inflammation, furthermore, intestine section showed Macro vesicular fatty change. The spleen histological Samples founded with highly-blood foci (bleeding), highly infiltration with lymphocytes, also section exhibit highly proliferative cells with abnormal blood collections in both groups treated with Xenical and Lipo-6,in comparative to normal spleen. the lung tissue inflammation, the production of air vacuoles, damage to the alveolar sac and found a significant RBC cast in the heart muscle.
Background and Aim: In this study rats, a systematic analysis was conducted to examine the antioxidant properties of cinnamon (Cinnamomum Zeylanicum, Breyne) in controlling high blood sugar levels, and a pharmacological comparison made to investigate whether or not it had a positive effect on the antioxidant system.Materials and Methods: Alloxan 60 mg injected into the marginal ear veins of eighteen diabetic rats After this diabetic animal study, the rats were randomly assigned to 4 groups. There were six animals in each of the 4 groups: Group 1(C): Positive control, Received orally 5 ml normal saline (0.9% NaCl) daily. Group 2(D): Negative control, Diabetes rats only, received single-dose alloxan 60 mg/kg body weight. Group 3(K): Diabetes rats, received cinnamon orally 35 mg/kg body weight dissolved in 2 ml normal. Group 4(I): Diabetes rats, was given 2 I.U/ animal of insulin subcutaneously daily.Results: All animal groups were treated for four weeks.Blood samples were taken from these groups weekly for biochemical analysis to estimate: Blood glucose malondialdehyde(MDA), Glutathione (GSH). The results showed high glucose and MDA concentration associated with an increased oxidant stress alloxan induces on diabetic animals. The statistical analysis showed that a cinnamon significant (P<0.05) reduction in glucose, MDA,GSH comparison with positive control. The level of MDA, GSH was also significantly reduced (P<0.05) in all period comparison with the period before treated with Cinnamon extract .there was 4.3-fold more Ins I upregulated in the Cinnamon -treated diabetic rats 35 percent of the control group were heterozygous and three percent of the experimental group were mutant for that trait. Conclusion:Furthermore, Cinnamon-treated diabetic rats (group K) showed a significant increase in the activities of both enzymatic and non-enzymatic antioxidants with concomitant overexpression of insulin I genes when compared to diabetic control rats (group D). Cinnamon contains antioxidants and antihyperglycemic effects at the end of the experiment.
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