Anti-obesity and lipid lowering effects of<i>Cymodocea nodosa</i>sulphated polysaccharide on high cholesterol-fed-rats

Kolsi, Rihab Ben Abdallah; Gara, Amel Ben; Chaaben, Rim; Feki, Abdelfattah El; Patti, Francesco Paolo; Feki, Lotfi El; Belghith, Karima

doi:10.3109/13813455.2015.1105266

Cited by 26 publications

(10 citation statements)

References 26 publications

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“…These results are in accordance with the results of Raida et al [32] and Ben Abdallah et al [51]. Many researchers showed the hepatoprotective effect of C. scolymus leaves extract, related to its active compounds.…”

Section: Discussionsupporting

confidence: 92%

LC-MS/MS Analysis and Hepatoprotective Activity of Artichoke (Cynara scolymusL.) Leaves Extract against High Fat Diet-Induced Obesity in Rats

Salem

Ksouda

Dhouibi

et al. 2019

BioMed Research International

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Cynara scolymus L. (Artichoke) has been used for the treatment of metabolic disorders. The purpose of the present study was to investigate the hepatoprotective effect of Cynara scolymus leaves extract against a high fat diet (HFD) induced rats. This study investigated the most abundant phenolic compounds rich Cynara scolymus leaves extract and it is antihypercholesterolemic and antioxidative effects in vivo. The hypercaloric high fat diet (HFD) was treated with 200 mg/kg and 400 mg/kg of ethanol extract (EEA) from leaves of Cynara and atorvastatin (ATOR) (10 mg/kg/day) during an 8-week period. Lipid profile was measured and oxidative stress systematic in hepatic tissue was determined. Our data revealed that HFD-induced hepatic dysfunction manifested by significant abnormal levels of AST, ALT, ALP, LDH, and OCT was accompanied by increasing levels of oxidative stress biomarker (ROS, MDA, and AOPP) while decreasing in antioxidant status. Coadministration of EEA significantly reduced serum lipid profile and hepatic disorders which was confirmed to be histological by reducing the fatty liver deposition in hepatic lobule. These findings suggest that Cynara leaves exert antiobesity and antioxidant liver effects in HFD-induced obese rats.

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Section: Discussionsupporting

confidence: 92%

LC-MS/MS Analysis and Hepatoprotective Activity of Artichoke (Cynara scolymusL.) Leaves Extract against High Fat Diet-Induced Obesity in Rats

Salem

Ksouda

Dhouibi

et al. 2019

BioMed Research International

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“…Cymodocea nodosa sulfated polysaccharides reduced total cholesterol levels, triglycerides, and LDL cholesterol, and increased HDL cholesterol levels. A decrease in body weight and lipase activity among obese rodents was noted in serum and intestine, respectively [88]. Codium fragile sulfated polysaccharides showed similar results, reducing total cholesterol, triglycerides, and LDL cholesterol while increasing HDL cholesterol concentrations [89].…”

Section: Polysaccharides and Msmentioning

confidence: 89%

Understanding the Role of the Gut Microbiome and Microbial Metabolites in Obesity and Obesity-Associated Metabolic Disorders: Current Evidence and Perspectives

et al. 2019

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Purpose In this review, we summarize current evidence on the gut microbiome and microbial metabolites in relation to obesity and obesity-associated metabolic disorders. Special emphasis is given on mechanisms interconnecting gut microbiome and microbial metabolites with metabolic disorders as well as on potential preventive and therapeutic perspectives with a "bench to bedside" approach. Recent Findings Recent data have highlighted the role of gut dysbiosis in the etiology and pathogenesis of metabolic disorders, including obesity, metabolic syndrome, type 2 diabetes mellitus, and non-alcoholic fatty liver disease. Overall, most studies have demonstrated a reduction in gut microbiome diversity and richness in obese subjects, but there is still much debate on the exact microbial signature of a healthy or an obese gut microbiome. Despite the controversial role of an altered gut microbiome as a cause or consequence of obesity in human studies, numerous animal studies and certain human studies suggest beneficial metabolic effects of certain microbial intestinal metabolites, such as butyrate, that could be used in the prevention and treatment of obesity and its comorbidities. Summary More randomized controlled trials and larger prospective studies including well-defined cohorts as well as a multiomics approach are warranted to better identify the associations between the gut microbiome, microbial metabolites, and obesity and its metabolic complications.

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“…Superoxide dismutase (SOD) is a free radical (super oxide) scavenging enzyme. Anti-obesity and lipid lowering effects were also related to antioxidant enzymes such as SOD [15]. In this experiment, these GAGs contributed to the increase of anti-oxidant activity and diminished cellular oxidative damage when anti-oxidative enzyme, SOD, or catalase activities were increased, whereas oxidative stress parameters, carbonyl content (protein oxidative damage), and malondialdehyde (MDA, lipid denaturant) in hepatocytes were diminished by the treatment of GbG, ISG, or IQG.…”

Section: Discussionmentioning

confidence: 99%

Anti-Obesity Effect of Bombus ignitus Queen Glycosaminoglycans in Rats on a High-Fat Diet

Ahn

Kim

et al. 2017

IJMS

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The mechanism of functional insect glycosaminoglycan (GAG) on obesity caused a high fat diet has not yet been elucidated. Therefore, insect glycosaminoglycans derived from Isaria sinclairii, Bombus ignitus (a type of bumblebee) queen, and Gryllus bimaculatus were purified and investigated as a potential functional food. 14-week old male Wistar rats were fed a high-fat diet (HFD) for 6 weeks. There were five groups that received daily intraperitoneal administration of phosphate buffered saline (PBS, control), GbG (GAG from Gryllus bimaculatus) 10 mg/kg, ISG (GAG from Isaria sinclairii) 10 mg/kg, IQG (GAG from Bombus ignites) 10 mg/kg, or Pravastatin (2 mg/kg). All treatments were performed for one month. IQG produced a potential anti-inflammatory effect with the inhibition of c-reactive protein and sero-biochemical parameters of phospholipids and free fatty acids indicative of an anti-hyperlipidemic effect. Abdominal and epididymidal fat weight were reduced in conjunction with a mild increase in body weight. The level of laminin in HMVEC-C cells or fibronectin in HFD rat hepatocytes was significantly affected by these GAG treatments, which regulated adipogenesis and adipocyte function. Compared to the control rats, IQG-treated rats displayed up-regulation of 87 genes (test:control ratio >2.0) including fatty acid synthase and 3-hydroxy-3-methylglutaryl-coenzyme A reductase, with the down-regulation of 47 genes including the uridine diphosphate (UDP) glycosyltransferase 2 families, polypeptidase B, and insulin-like growth factor binding protein 1. The data suggest that IQG could potentially prevent or treat fatty liver or hyperlipidemia.

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Anti-obesity and lipid lowering effects ofCymodocea nodosasulphated polysaccharide on high cholesterol-fed-rats

Cited by 26 publications

References 26 publications

LC-MS/MS Analysis and Hepatoprotective Activity of Artichoke (Cynara scolymusL.) Leaves Extract against High Fat Diet-Induced Obesity in Rats

LC-MS/MS Analysis and Hepatoprotective Activity of Artichoke (Cynara scolymusL.) Leaves Extract against High Fat Diet-Induced Obesity in Rats

Understanding the Role of the Gut Microbiome and Microbial Metabolites in Obesity and Obesity-Associated Metabolic Disorders: Current Evidence and Perspectives

Anti-Obesity Effect of Bombus ignitus Queen Glycosaminoglycans in Rats on a High-Fat Diet

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