Anti Obesity activity of <i>Rhynchosia beddomei</i> by using Progesteron induced obesity in mice, and mono sodium glutamate induced obesity in rats.

Sultana, Habeeba; Sameena, Tahseen; Siddiqua, Hafsa; Unnisa, Kouser

doi:10.5958/0974-4150.2017.00045.1

Cited by 3 publications

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“…The foremost consideration in therapy for hyperlipidemia and arteriosclerosis is to rectify the elevated plasma level of total cholesterol (TC), triglyceride, and low‐density lipoprotein along with an increase in high‐density lipoprotein lipid levels (Iyer & Patil, 2019; Sultana, Sameena, Siddiqua, & Unnisa, 2017). However, the use of lipid‐lowering conventional drugs has been restricted due to several side effects (Chien et al, 2019; Komolafe et al, 2013).…”

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confidence: 99%

Toxicological and pharmacological assessment of a multiherbal phytopharmaceutical on Triton X‐1339‐induced hyperlipidemia and allied biochemical dysfunctions

et al. 2020

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This study investigated the safety and therapeutic effect of a multiherbal tea (MHT) on Triton X-1339-induced hyperlipidemia and associated biochemical and tissue dysfunctions. An infusion of the MHT was assessed for phytoconstituents, proximate and mineral composition, and antioxidant activity. Wistar rats administered 200 mg/ kg Triton X-1399 were post-treated with MHT for 14 days followed by biochemical estimations in serum, heart, liver, and kidney of animals. Hematological and histopathological evaluations of the blood, and liver, respectively, were also performed. Different phytochemicals were detected in MHT, toxic metals were absent and antioxidant activity was appreciable. Disturbances in glucose level and redox homeostasis, alterations in liver, kidney, and heart function markers, and imbalances in hematological parameters precipitated by triton toxicity were mitigated by posttreatment with MHT. Multiherbal tea also ameliorated triton-induced hepatic histoarchitectural abnormalities. These results suggest that MHT is apparently an effective antilipemic tea with minimal or no side effects. Practical applications Hyperlipidemia is one of the core risk factors for arteriosclerosis and a major contributor to other adverse health conditions. The prevalence of hyperlipidemia has increased drastically in the last few decades. Plant and plant products have been extensively used in the management of dyslipidemia and many plant-based antilipemic products with poorly defined toxicity and pharmacological profiles abound in the market. The results of this study demonstrated the protective effects of a MHT against triton-induced hyperlipidemia, atherogenic tendency, and dysfunction of key organs in rats and lent credence to its therapeutic relevance in the management of hyperlipidemia and related diseases. K E Y W O R D S antilipemic, hyperlipidemia, multiherbal tea, multi-organ protection, oxidative stress 1999) radicals scavenging activities as well as cupric ion (Cu 2+) reducing capacity (Apak, Güçlü, Ozyürek, & Karademir, 2004). 2.4 | Determination of proximate and mineral composition of MHT The proximate and mineral compositions of MHT were determined following previously established protocols (Horwitz & Latimer, 2005). 2.5 | In vivo evaluation of MHT in Triton-induced hyperlipidemia 2.5.1 | Animal grouping and treatment Male Wistar rats weighing 180 ± 20 g were obtained from the

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Section: Introductionmentioning

confidence: 99%

Toxicological and pharmacological assessment of a multiherbal phytopharmaceutical on Triton X‐1339‐induced hyperlipidemia and allied biochemical dysfunctions

et al. 2020

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Prevalance and role of Melatonin on PCOS in its treatment using Herbal Drugs

Ahamed

Sumitra

Chitra

2021

RJPT

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The polycystic ovarian syndrome is a convoluted endocrine disorder of the reproductive system which influences several girls with puberty and 6-8% of germinating women in endemic populations and displays a wide spectrum of clinical phenomenon. This disorder was first reported in 1935 as a synthetic clinical error for its associations with high androgen levels, hyperinsulinemia, and PCOS. The pineal hormone melatonin is known to regulate a mixture of central and peripheral actions related to circadian rhythms. It is a pleiotropic fragment, which plays a vital role in female reproduction as a capable free radical hunter and involves many gynecological and obstetrical pathology. PCOS is a compound condition for which the symptoms are irregular, and the cause is anonymous. Herbal products like Yastimadhu (Glycyrrhiza glabra), Kumari (Aloe vera), Tvaka (Cinnamomum Zeylanicum), Mostly the Ayurvedic drugs used for the PCOS, all are Vata-kapha shamaka. Neurological associated in pcos is still in the platform of research, no drugs melatonin an important modulator in pcos can be concentrated to cure pcos. Melatonin might be effective against neurological associate pcos. In ayurvedic way of treatment it can be cured with several natural drugs.

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Effects of Polyphenols on changes in the transport of Ca2+ NMDA-receptors under the influence of L-glutamate

Khoshimov

Mukhtorov

Nasirov

et al. 2023

RJPT

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Increasing amount of evidence suggests that age-related dysregulation of neuronal Ca2+ homeostasis may play a proximal role in the pathogenesis of Alzheimer's disease, as impaired Ca2+ can cause synaptic deficits and contribute to the accumulation of Aβ plaques and neurofibrillary tangles.Ca2+ disruption is known to be mostly involved in all pathologies of Alzheimer's disease, the use of chemical agents or small molecules specific for Ca2+ channels, or the treatment of proteins on the plasma membrane and intracellular organelle membranes for correction is quite possible. Neuronal dysregulation of Ca2+ may open up a new approach to the prevention and treatment of Alzheimer's disease. The article shows the possible competition between the polyphenols PС-6, PС-7 and glutamate for the area of regulation of the opening of ion channels of ionotropic NMDA-receptors in the brain of rats.

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Anti Obesity activity of Rhynchosia beddomei by using Progesteron induced obesity in mice, and mono sodium glutamate induced obesity in rats.

Cited by 3 publications

References 0 publications

Toxicological and pharmacological assessment of a multiherbal phytopharmaceutical on Triton X‐1339‐induced hyperlipidemia and allied biochemical dysfunctions

Toxicological and pharmacological assessment of a multiherbal phytopharmaceutical on Triton X‐1339‐induced hyperlipidemia and allied biochemical dysfunctions

Prevalance and role of Melatonin on PCOS in its treatment using Herbal Drugs

Effects of Polyphenols on changes in the transport of Ca2+ NMDA-receptors under the influence of L-glutamate

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