Anti-nociceptive synergism of morphine and gabapentin in neuropathic pain induced by chronic constriction injury

O-Arciniega, Minarda De la; Dı́az-Reval, Marı́a Irene; Cortés-Arroyo, Alma Rosa; Domínguez-Ramírez, Adriana Miriam; López‐Muñoz, Francisco

doi:10.1016/j.pbb.2009.01.013

Cited by 43 publications

(30 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[22] As per previous reports, gabapentin did not produce any anti allodynic effect in neuropathic pain induced by CCI in rats. [23] However, in our study gabapentin produced anti allodynic effect but did not increase the withdrawal latency in hot plate method. The effect shown by gabapentin is similar to our earlier study in paclitaxel induced neuropathic pain where gabapentin was effective in mechanical allodynia but did not show a significant response in hot plate withdrawal latency.…”

Section: Discussioncontrasting

confidence: 67%

Comparing the efficacy of carbamazepine, gabapentin and lamotrigine in chronic constriction injury model of neuropathic pain in rats

Chogtu

Bairy

Himabindu

et al. 2013

Int J Nutr Pharmacol Neurol Dis

View full text Add to dashboard Cite

Context: Anti-epileptics are used in the treatment of neuropathic pain. Newer anti-epileptics with improved safety profile are being used in neuropathic pain. The animal models of neuropathic pain have helped to find newer drugs for this condition. As the efficacy of these drugs is modest, there is always a need to compare the efficacy of newer anti-epileptics with conventional drugs in this condition. Aims: The aim of this study was to compare the efficacy of anti-epileptics in neuropathic pain induced by chronic constriction injury. Settings and Design: It was a randomised, prospective study. Materials and Methods: The rats were divided into four groups. The first three groups were administered each of carbamazepine, gabapentin and lamotrigine respectively and the fourth group acted as control. Assessment was started on day five of surgery by hot plate method and Randall Selitto test. Statistical Analysis Used: Statistical analysis was done by one way analysis of variance followed by posthoc test. Results: In mechanical allodynia rats treated with lamotrigine and gabapentin (P = 0.001) showed a significant increase in mechanical threshold whereas in thermal hyperalgesia, it was the carbamazepine (P = 0.027) which was superior to other two drugs. Conclusions: Lamotrigine and gabapentin are efficacious in mechanical allodynia whereas carbamazepine is superior in thermal hyperalgesia. This shows that effect of drugs vary in different behavioral tests. So, the choice of treatment in different types of neuropathic pain can vary.

show abstract

Section: Discussioncontrasting

confidence: 67%

Comparing the efficacy of carbamazepine, gabapentin and lamotrigine in chronic constriction injury model of neuropathic pain in rats

Chogtu

Bairy

Himabindu

et al. 2013

Int J Nutr Pharmacol Neurol Dis

View full text Add to dashboard Cite

show abstract

“…The combination of gabapentin and morphine, which were ineffective alone, produced a significant analgesic effect in an animal writhing model of pain (Meymandi and Sepehri 2008). Gabapentin alone did not produce an anti-nociceptive effect, whereas the combined treatment of morphine and gabapentin completely decreased allodynia behaviour at 30 min post-injection, an effect that persisted until 120 min in neuropathic pain induced by chronic constriction injury in rat (De la O-Arciniega et al 2009). Moreover, the anti-nociceptive effect induced by gabapentin may be inhibiting via the release of an inflammatory mediator.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have demonstrated that gabapentin enhanced the anti-nociceptive effect of morphine in neuropathic pain and visceral pain rats (Smiley et al 2004; De la O-Arciniega et al 2009). The combination of gabapentin and morphine, which were ineffective alone, produced a significant analgesic effect in an animal writhing model of pain (Meymandi and Sepehri 2008).…”

Section: Discussionmentioning

confidence: 99%

Gabapentin Enhances the Morphine Anti-Nociceptive Effect in Neuropathic Pain via the Interleukin-10-Heme Oxygenase-1 Signalling Pathway in Rats

et al. 2014

View full text Add to dashboard Cite

In the present study, we investigated the anti-inflammatory mechanisms by which gabapentin enhances morphine anti-nociceptive effect in neuropathic pain in rats and the interaction between the anti-nociceptive effects of gabapentin on morphine and the interleukin (IL)-10-heme-oxygenase (HO)-1 signal pathway in a rat model of neuropathic pain. The neuropathic pain model was induced via a left L5/6 spinal nerve ligation (SNL) in rats. The anti-nociceptive effect of gabapentin and IL-10 on morphine was examined over a 7-day period, and the effects of the anti-IL-10 and HO-1 inhibitor zinc protoporphyrin (ZnPP) on gabapentin/morphine co-injection were assessed. Drug administration was given over 7 days, and on day 8, both anti-inflammatory cytokine IL-10, a stress-induced protein HO-1 and pro-inflammatory cytokines IL-1β, IL-6 and TNF-α were measured. Gabapentin attenuated morphine tolerance over 7 days of co-administration, and reduced the expression of pro-inflammatory cytokines but increased IL-10 and HO-1 expression. The effect of gabapentin on morphine was partially blocked using the anti-IL-10 antibody or the HO-1 inhibitor zinc protoporphyrin. Our findings indicated that the anti-nociceptive effects of gabapentin on morphine might be caused by activation of the IL-10-HO-1 signalling pathway, which resulted in the inhibition of the expression of pro-inflammatory cytokines in neuropathic pain in the rat spinal cord.

show abstract

“…Eckhardt et al [33] demonstrated that gabapentin increases analgesic effect of morphine in normal volunteers. Gabapentin [34,35] has also demonstrated to significantly enhance the antinociceptive effect of morphine in neuropathic pain in rats. Hansen et al [36] reported that, behaviorally, intrathecally administered gabapentin prevents morphineinduced tolerance.…”

Section: Discussionmentioning

confidence: 99%

Role of gabapentin in preventing fentanyl- and morphine-withdrawal-induced hyperalgesia in rats

Wei

2011

J Anesth

View full text Add to dashboard Cite

show abstract

Anti-nociceptive synergism of morphine and gabapentin in neuropathic pain induced by chronic constriction injury

Cited by 43 publications

References 36 publications

Comparing the efficacy of carbamazepine, gabapentin and lamotrigine in chronic constriction injury model of neuropathic pain in rats

Comparing the efficacy of carbamazepine, gabapentin and lamotrigine in chronic constriction injury model of neuropathic pain in rats

Gabapentin Enhances the Morphine Anti-Nociceptive Effect in Neuropathic Pain via the Interleukin-10-Heme Oxygenase-1 Signalling Pathway in Rats

Role of gabapentin in preventing fentanyl- and morphine-withdrawal-induced hyperalgesia in rats

Contact Info

Product

Resources

About