Anti-nociceptive and anti-inflammatory activities of the Agastache mexicana extracts by using several experimental models in rodents

González-Ramírez, Adriana Estrella; González-Trujano, María Eva; Pellicer, Francisco; López‐Muñoz, Francisco

doi:10.1016/j.jep.2012.05.044

Cited by 28 publications

(7 citation statements)

References 26 publications

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“…xolocotziana exhibited anti-nociceptive activity, demonstrated in an animal study using rats and mice (Gonzalez-Trujano et al 2012; Gonzalez-Ramirez et al 2012). In a set of complementary tests, hexane, ethyl acetate and methanol extracts from macerated inflorescences were compared.…”

Section: Bioactivity Of Individual Species As Medicinal Plantsmentioning

confidence: 98%

Phytochemistry and bioactivity of aromatic and medicinal plants from the genus Agastache (Lamiaceae)

2014

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Agastache is a small genus of Lamiaceae, comprising 22 species of perennial aromatic medicinal herbs. In this article, we review recent advances in phytochemical, pharmacological, biotechnological and molecular research on Agastache. The phytochemical profile of all Agastache species studied to date is generally similar, consisted of two main metabolic classes—phenylpropanoids and terpenoids. In the relatively variable essential oils, most populations of different Agastache species contain over 50 % of a phenylallyl compound—estragole. Also, other volatile compounds (methyleugenol, pulegone, menthone, isomenthone and spathulenol) were reported in various proportions. Major non-volatile metabolites belong to phenolic compounds, such as caffeic acid derivatives, especially rosmarinic acid as well as several flavones and flavone glycosides like acacetin, tilianin, agastachoside, and a rare dimeric malonyl flavone (agastachin). Two unique lignans—agastenol and agastinol—were also isolated. Terpenoids include triterpenoids of oleanane-type (maslinic acid, oleanolic acid and β-amyrin), ursane-type (ursolic acid, corosolic acid and α-amyrin), and typical plant sterols, as well as abietane-type oxidized diterpenes (e.g., agastaquinone, agastol, and others). The bioactivity of various extracts or individual compounds in vitro and in vivo include antimicrobial, antiviral and anti-mutagenic activity, cytotoxic activity to cancer cell lines, and anti-nociceptive, anti-inflammatory, anti-atherogenic, antioxidant as well as biocidal activity to several foodstuff pests. Biotechnological and molecular studies have focused on in vitro propagation and enhancing the biosynthesis of bioactive metabolites in cell or organ cultures, as well as on the expression of genes involved in phenolic biosynthesis.

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Section: Bioactivity Of Individual Species As Medicinal Plantsmentioning

confidence: 98%

Phytochemistry and bioactivity of aromatic and medicinal plants from the genus Agastache (Lamiaceae)

2014

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“…NER is found in many essential oils, such as Agastache mexicana [ 200 ] and Citrus aurantium [ 201 ]. In previous study, González-Ramírez and collaborators [ 202 ] reported the antinociceptive effect of hexane extract from A. mexicana aerial parts in the acetic acid-induced writhing model in rodents. As it has been reported the abundant presence of NER in this species [ 203 ], the authors suggested that this monoterpene is partially responsible by antinociceptive and anti-inflammatory activities of A. mexicana [ 202 ].…”

Section: Resultsmentioning

confidence: 99%

“…In previous study, González-Ramírez and collaborators [ 202 ] reported the antinociceptive effect of hexane extract from A. mexicana aerial parts in the acetic acid-induced writhing model in rodents. As it has been reported the abundant presence of NER in this species [ 203 ], the authors suggested that this monoterpene is partially responsible by antinociceptive and anti-inflammatory activities of A. mexicana [ 202 ]. With this background, González-Ramírez and collaborators [ 203 ] evaluated the influence of NER in the emergence of pathological markers and hyperalgesia in oxazolone-induced colitis, as well as whether this monoterpene protects against gastric damage induced by ethanol.…”

Section: Resultsmentioning

confidence: 99%

Analgesic-Like Activity of Essential Oil Constituents: An Update

Sá

Lima

Nóbrega

et al. 2017

IJMS

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The constituents of essential oils are widely found in foods and aromatic plants giving characteristic odor and flavor. However, pharmacological studies evidence its therapeutic potential for the treatment of several diseases and promising use as compounds with analgesic-like action. Considering that pain affects a significant part of the world population and the need for the development of new analgesics, this review reports on the current studies of essential oils’ chemical constituents with analgesic-like activity, including a description of their mechanisms of action and chemical aspects.

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“…Antibacterial [ 21 ] antiparasitic [ 22 ], antidiabetic [ 23 ] anxiolytic or antidepressant [ 24 , 25 ], anti-cancer [ 26 , 27 ], and cardiovascular [ 28 ] effects exhibited by Mexican herbalism products have been demonstrated in preclinical studies. On the other hand, the use of medicinal plants to treat headaches, rheumatic pain, and chronic pain conditions has been documented in Mexican culture [ 29 , 30 , 31 ]. In this field, there has not been a review of the anti-pain properties of these plants, focusing on the mechanism of actions and adverse effects produced by the most consumed plants in the Mexican population.…”

Section: Introductionmentioning

confidence: 99%

Mexican Plants and Derivates Compounds as Alternative for Inflammatory and Neuropathic Pain Treatment—A Review

Quiñonez-Bastidas

Navarrete

2021

Plants

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Despite the availability of many anti-pain drugs, in the form of NSAIDs, steroids, gabapentinoids, opioids, and antidepressants, in this study we address the natural compounds belonging to the group of Mexican medicinal plants or “Mexican folk medicine”, used for pain management in Mexico. Our interest in this subject is due to the growing idea that “natural is harmless” and to the large number of side effects exhibited in pharmacotherapy. The objective of this review was to document the scientific evidence about Mexican medicinal plants and their derivatives used for inflammatory and neuropathic pain treatment, as well as the mechanisms of action implicated in their antinociceptive effects, their possible adverse effects, and the main pharmacological aspects of each plant or compound. Our data review suggested that most studies on Mexican medicinal plants have used inflammatory experimental models for testing. The anti-pain properties exerted by medicinal plants lack adverse effects, and their toxicological assays report that they are safe to consume; therefore, more studies should be performed on preclinical neuropathic pain models. Moreover, there is no convincing evidence about the possible mechanisms of action involved in the anti-pain properties exerted by Mexican plants. Therefore, the isolation and pharmacological characterization of these plant derivatives’ compounds will be important in the design of future preclinical studies.

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Anti-nociceptive and anti-inflammatory activities of the Agastache mexicana extracts by using several experimental models in rodents

Cited by 28 publications

References 26 publications

Phytochemistry and bioactivity of aromatic and medicinal plants from the genus Agastache (Lamiaceae)

Phytochemistry and bioactivity of aromatic and medicinal plants from the genus Agastache (Lamiaceae)

Analgesic-Like Activity of Essential Oil Constituents: An Update

Mexican Plants and Derivates Compounds as Alternative for Inflammatory and Neuropathic Pain Treatment—A Review

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