Anti-neuroinflammatory diarylheptanoids from the rhizomes of Dioscorea nipponica

Woo, Kyeong Wan; Moon, Eunjung; Kwon, Oh Wook; Lee, Sung Ok; Kim, Sun Yeou; Choi, Sang Zin; Son, Miwon; Lee, Kang Ro

doi:10.1016/j.bmcl.2013.04.073

Cited by 28 publications

(16 citation statements)

References 25 publications

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“…Therefore, the effects exerted by the novel diarylheptanoids on these latter targets could be whether direct inhibitory effects or consequence of NF-κB inhibition. Surprisingly, the new synthesized molecules showed anti-neuroinflammatory features at 0.01 µM, a very low concentration respect to the reported cyclic ether diarylheptanoids [36] and respect to the natural linear diaryheptanoids [37] which showed anti-inflammatory and antioxidant proprieties at higher concentration, 30 µM and 13 µM, respectively.…”

Section: Discussionmentioning

confidence: 65%

New synthesized polyoxygenated diarylheptanoids suppress lipopolysaccharide-induced neuroinflammation

Santarsiero

Bochicchio

Funicello

et al. 2020

Biochemical and Biophysical Research Communications

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In neurodegenerative diseases, such as Alzheimer´s disease, Huntington's disease, Parkinson's disease and multiple sclerosis, neuroinflammation induced by the microglial activation plays a crucial role. In effort to develop effective anti-neuroinflammatory compounds, different new linear polyoxygenated diarylheptanoids were synthesized. In LPS-triggered BV-2 microglial cells their ability to reduce the concentration of IL-6 and TNF-α pro-inflammatory cytokines was evaluated. Moreover, their effect on NF-κB and ATP citrate lyase (ACLY), a recently emerged target of metabolic reprogramming in inflammation, was assessed. Finally, we turn our attention to 2 inflammatory mediators derived from the cleavage of citrate catalyzed by ACLY: prostaglandin E2, nitric oxide and reactive oxygen species. All compounds showed null or minimal cytotoxicity; most of them had a great anti-neuroinflammatory activity. Diarylheptanoids 6b and 6c, bearing a halide atom and benzyl ether protective groups, exhibited the best effect since they blocked the secretion of all inflammatory mediators analyzed and reduced NF-κB and ATP citrate lyase protein levels.

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Section: Discussionmentioning

confidence: 65%

New synthesized polyoxygenated diarylheptanoids suppress lipopolysaccharide-induced neuroinflammation

Santarsiero

Bochicchio

Funicello

et al. 2020

Biochemical and Biophysical Research Communications

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“…Their inhibitory effect on NO production in LPS-stimulated RAW 264. 48 and for 99 an IC50 value of 30 µM (in LPS-activated RAW 264.7 macrophages compared to L-NMMA : IC50 = 41.9 µM). 23 Derivatives 87 and 88 showed weak activity with IC50 values of 75.7 and 82.8 µM respectively, while IC50 values of meso-hanokinol (100) and (+)-hanokinol (101) were found above 100 µM.…”

Section: Linear Natural Diarylheptanoidsmentioning

confidence: 97%

“…In 2013, Kang Ro Lee and coworkers 48 The genus Alpinia is an important member of Zingiberaceae family widely distributed in Asia from which 143 diarylheptanoids were isolated in 2017. 49 From the 1980's, anti-inflammatory activities of yakuchinone A (36) and yakuchinone B (37), isolated from Alpinia oxyphylla (Zingiberaceae) used for centuries in traditional medicine for inflammatory disorders, have attracted interest.…”

Section: Linear Natural Diarylheptanoidsmentioning

confidence: 99%

Anti-inflammatory activity of naturally occuring diarylheptanoids – A review

Vanucci-Bacqué

Bedos‐Belval

2021

Bioorganic & Medicinal Chemistry

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Inflammation involving the innate and adaptive immune systems is a normal response to infection. However, if it becomes uncontrolled, inflammation may result in autoimmune or auto inflammatory disorders, neurodegenerative diseases or cancers. The currently available anti-inflammatory drug therapy is often not successful or induces severe side effects. Thus, the search of new therapeutic options for the treatment of inflammation is highly required. Medicinal plants have been an interesting source for obtaining new active compounds. Diarylheptanoids characterized by a 1, 7-diphenylheptane structural skeleton, are a class of secondary plant metabolites that have gained increasing interest over the last few decades due to a wide variety of biological activities. This review covers 182 natural linear or macrocyclic diarylheptanoids described in the period of 1982 to 2020 with anti-inflammatory activities evaluated using quantified in vitro and/or in vivo assays. All of these data highlight the pharmacological potential of these natural compounds to act as anti-inflammatory drugs.

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“…It not only induces nerve growth factor expression but also inhibits NO production in LPS-stimulated BV2 cells without cell toxicity. In addition, it predominantly suppresses elevated neurite outgrowth in N2a cells [ 75 ].…”

Section: Introductionmentioning

confidence: 99%

Nitric Oxide as a Target for Phytochemicals in Anti-Neuroinflammatory Prevention Therapy

Subedi

Gaire

Parveen

et al. 2021

IJMS

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Nitric oxide (NO) is a neurotransmitter that mediates the activation and inhibition of inflammatory cascades. Even though physiological NO is required for defense against various pathogens, excessive NO can trigger inflammatory signaling and cell death through reactive nitrogen species-induced oxidative stress. Excessive NO production by activated microglial cells is specifically associated with neuroinflammatory and neurodegenerative conditions, such as Alzheimer’s and Parkinson’s disease, amyotrophic lateral sclerosis, ischemia, hypoxia, multiple sclerosis, and other afflictions of the central nervous system (CNS). Therefore, controlling excessive NO production is a desirable therapeutic strategy for managing various neuroinflammatory disorders. Recently, phytochemicals have attracted considerable attention because of their potential to counteract excessive NO production in CNS disorders. Moreover, phytochemicals and nutraceuticals are typically safe and effective. In this review, we discuss the mechanisms of NO production and its involvement in various neurological disorders, and we revisit a number of recently identified phytochemicals which may act as NO inhibitors. This review may help identify novel potent anti-inflammatory agents that can downregulate NO, specifically during neuroinflammation and neurodegeneration.

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Anti-neuroinflammatory diarylheptanoids from the rhizomes of Dioscorea nipponica

Cited by 28 publications

References 25 publications

New synthesized polyoxygenated diarylheptanoids suppress lipopolysaccharide-induced neuroinflammation

New synthesized polyoxygenated diarylheptanoids suppress lipopolysaccharide-induced neuroinflammation

Anti-inflammatory activity of naturally occuring diarylheptanoids – A review

Nitric Oxide as a Target for Phytochemicals in Anti-Neuroinflammatory Prevention Therapy

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