2020
DOI: 10.3390/molecules25214895
|View full text |Cite
|
Sign up to set email alerts
|

Anti-neoplastic Potential of Flavonoids and Polysaccharide Phytochemicals in Glioblastoma

Abstract: Clinically, gliomas are classified into four grades, with grade IV glioblastoma multiforme being the most malignant and deadly, which accounts for 50% of all gliomas. Characteristically, glioblastoma involves the aggressive proliferation of cells and invasion of normal brain tissue, outcomes as poor patient prognosis. With the current standard therapy of glioblastoma; surgical resection and radiotherapy followed by adjuvant chemotherapy with temozolomide, it remains fatal, because of the development of drug re… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
17
0

Year Published

2021
2021
2023
2023

Publication Types

Select...
6
2
1

Relationship

1
8

Authors

Journals

citations
Cited by 27 publications
(23 citation statements)
references
References 216 publications
(280 reference statements)
0
17
0
Order By: Relevance
“…TCMSP has been utilized to screen active flavonoid ingredients [ 7 ]. Flavonoids are categorized according to their molecular structures into flavones, flavonols, isoflavones, chalcones, flavones, and anthocyanidins [ 4 ], as shown in Table 1 . Key parameters were taken into account, such as oral bioavailability (OB), drug-likeness (DL), and blood-brain barrier (BBB).…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…TCMSP has been utilized to screen active flavonoid ingredients [ 7 ]. Flavonoids are categorized according to their molecular structures into flavones, flavonols, isoflavones, chalcones, flavones, and anthocyanidins [ 4 ], as shown in Table 1 . Key parameters were taken into account, such as oral bioavailability (OB), drug-likeness (DL), and blood-brain barrier (BBB).…”
Section: Methodsmentioning
confidence: 99%
“…Glioma, originated from the neuroepithelium, accounts for 40%∼50% of brain tumors and is one of the most common primary intracranial tumors; among them, glioblastoma is a highly malignant one with poor clinical outcome [ 1 ]. Extensive studies have shown that flavonoids have a good therapeutic effect on glioma [ 2 – 4 ]; however, the underlying therapeutic molecular mechanisms of flavonoids on glioma are not stated clearly. Hence, a systematic exploration of the molecular mechanisms of flavonoids on glioma is critical.…”
Section: Introductionmentioning
confidence: 99%
“…Flavonoids are a group of bioactive polyphenolic agents structurally diverse with low toxicity [ 269 , 270 ]. They have been studied for their anti-cancer properties in glioma models [ 271 , 272 , 273 , 274 ]. Galangin (3, 5, 7-trihydroxyflavone), a natural flavonoid from roots of Alpinia officinarum Hance, Alnus pendula Matsum, Plantago major L, and Scutellaria galericulata L. (S.scrodifolia Fisch .…”
Section: Phytochemicals and Nanoparticles In Hggmentioning
confidence: 99%
“…Another protein that regulates apoptosis is p53 which activates BAX. Quercetin exposure leads to caspases 3 and 9 activations, causing a release of cytochrome c from the mitochondria also reducing the mitochondrial membrane potential [ 129 ].…”
Section: Natural Compounds In Gbmmentioning
confidence: 99%