Anti-myocardial ischaemic effect of pseudoginsenoside F11 by inhibiting expression of beta1-adrenoceptor in rats with coronary artery ligation

Zhang, Nanqi; Wang, Cuizhu; Wang, Zhenzhou; Li, Zhuo; Sai, Jingying; Meng, Yan; Wang, Fang; Li, Pingya; Liu, Jinping

doi:10.1016/j.jff.2017.06.053

Cited by 8 publications

(6 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The Protein Preparation Wizard in the GLIDE software was used to prepare the receptors. The structures of EGF and NOS2 were optimized after a series of processes, including assigning bond orders and water orentations, removing water, adding hydrogen, and creating zero-order bonds to metals and disulphide bonds [16].…”

Section: Methodsmentioning

confidence: 99%

Evaluation of the gastroprotective effects of 20 (S)-ginsenoside Rg3 on gastric ulcer models in mice

Zhang

Liu

Wang

et al. 2019

Journal of Ginseng Research

View full text Add to dashboard Cite

BackgroundGastric ulcer (GU) is a common gastrointestinal disease that can be induced by many factors. Finding an effective treatment method that contains fewer side effects is important. 20 (S)-ginsenoside Rg3 is a kind of protopanaxadiol and has shown superior antiinflammatory and antioxidant effects in many studies, especially cancer studies. In this study, we examined the treatment efficacy of 20 (S)-ginsenoside Rg3 on GU.MethodsThree kinds of GU models, including an alcohol GU model, a pylorus-ligated GU model, and an acetic acid GU model, were used. Mouse endothelin-1 (ET-1) and nitric oxide (NO) levels in blood and epidermal growth factor (EGF), superoxide dismutase, and NO levels in gastric mucosa were evaluated. Hematoxylin and eosin staining of gastric mucosa and immunohistochemical staining of ET-1, inducible nitric oxide synthase (NOS2), and epidermal growth factor receptors were studied. Ulcer index (UI) scores and UI ratios were also analyzed to demonstrate the GU conditions in different groups. Furthermore, Glide XP from Schrödinger was used for molecular docking to clarify the interactions between 20 (S)-ginsenoside Rg3 and EGF and NOS2.Results20 (S)-ginsenoside Rg3 significantly decreased the UI scores and UI ratios in all the three GU models, and it demonstrated antiulcer effects by decreasing the ET-1 and NOS2 levels and increasing the NO, superoxide dismutase, EGF, and epidermal growth factor receptor levels. In addition, high-dose 20 (S)-ginsenoside Rg3 showed satisfactory gastric mucosa protection effects.Conclusion20 (S)-ginsenoside Rg3 can inhibit the formation of GU and may be a potential therapeutic agent for GU.

show abstract

Section: Methodsmentioning

confidence: 99%

Evaluation of the gastroprotective effects of 20 (S)-ginsenoside Rg3 on gastric ulcer models in mice

Zhang

Liu

Wang

et al. 2019

Journal of Ginseng Research

View full text Add to dashboard Cite

show abstract

“…In addition, PF11, the characteristic component of PQR, could reduce the levels of MDA, aspartate aminotransferase (AST), creatine kinase (CK), LDH, cardiac troponin T (cTnT), increase the activity of SOD, and significantly improve cardiac function and reduce the area of myocardial infarction. PF11 could be used as a natural antimyocardial ischemia drug to improve cardiac function (Zhang et al, 2017).…”

Section: Cardioprotective Effectmentioning

confidence: 99%

“…In addition, protopanaxdiol (PDG) and Protopanaxatriol (PTG) types of ginsenosides in PQR leaves can prevent and treat obesity, fatty liver and hypertriglyceridemia in mice fed with high-fat diet ( Liu et al, 2010 ). The mechanism may be mainly through the regulation of linoleic acid metabolism, cysteine and methionine metabolism, and the biosynthesis of unsaturated fatty acids ( Zhang et al, 2019 ). PQR could significantly reduced body weight and plasma insulin and C-peptide levels of type II diabetic animals, while increased body weight and plasma insulin and C-peptide levels of type I diabetic animals.…”

Section: Physiochemical Compositionmentioning

confidence: 99%

Panacis Quinquefolii Radix: A Review of the Botany, Phytochemistry, Quality Control, Pharmacology, Toxicology and Industrial Applications Research Progress

et al. 2020

View full text Add to dashboard Cite

On January 2, 2020, The National Health Commission and the State Administration for Market Regulation listed Panacis Quinquefolii Radix (PQR) as a medicinal and food homologous product. PQR is the dry root of Panax quinquefolium L., which has the functions of replenishing qi and nourishing Yin, clearing heat and producing body fluid. It is often used for qi deficiency and Yin deficiency, heat exhaustion, asthma and phlegm, dry mouth and pharynx. PQR is sweet, slightly bitter and cool in nature, and enter the heart, lung and kidney meridian exerts the remedial and hygienical effect. At present, active components such as saponins, flavonoids, fatty acids, polyalkynes, volatile oils and other nutrients such as amino acids, carbohydrates, vitamins and trace elements have been isolated from PQR. Modern pharmacological studies have shown that PQR has the effects of hypoglycemic, antihypertensive, anti fatigue, anti-oxidation, anti-tumor, immunomodulatory, neuroprotective and so on. In addition, PQR is recognized as a health care product to strengthen the body and dispel diseases. It is not only the raw material of Traditional Chinese medicine preparations, but also the treasure of dietary therapy and herbal cuisine. This study not only reviewed the botany, phytochemistry and pharmacology of PQR, but also summarized its quality control, toxicity and industrial applications for the first time. This paper not only summarizes the development status of PQR, but also analyzes the shortcomings of the current research on PQR, and puts forward the corresponding solutions, in order to provide reference for future scholars to study PQR.

show abstract

“…The structures of proteins were optimized aer a series of processes, including assigning bond orders and water orientations, removing water, adding hydrogen, and creating zero-order bonds to metals and disulphide bonds. 24 Two-dimensional structure of PDQ (ligand) were drawn with Maestro Elements (Maestro Elements, 2.2).…”

Section: Molecular Docking Of Pdqmentioning

confidence: 99%

Pseudo-ginsengenin DQ ameliorated aconitine-induced arrhythmias by influencing Ca²⁺ and K⁺ currents in ventricular myocytes

et al. 2020

View full text Add to dashboard Cite

show abstract

Anti-myocardial ischaemic effect of pseudoginsenoside F11 by inhibiting expression of beta1-adrenoceptor in rats with coronary artery ligation

Cited by 8 publications

References 32 publications

Evaluation of the gastroprotective effects of 20 (S)-ginsenoside Rg3 on gastric ulcer models in mice

Evaluation of the gastroprotective effects of 20 (S)-ginsenoside Rg3 on gastric ulcer models in mice

Panacis Quinquefolii Radix: A Review of the Botany, Phytochemistry, Quality Control, Pharmacology, Toxicology and Industrial Applications Research Progress

Pseudo-ginsengenin DQ ameliorated aconitine-induced arrhythmias by influencing Ca²⁺ and K⁺ currents in ventricular myocytes

Contact Info

Product

Resources

About

Anti-myocardial ischaemic effect of pseudoginsenoside F11 by inhibiting expression of beta1-adrenoceptor in rats with coronary artery ligation

Cited by 8 publications

References 32 publications

Evaluation of the gastroprotective effects of 20 (S)-ginsenoside Rg3 on gastric ulcer models in mice

Evaluation of the gastroprotective effects of 20 (S)-ginsenoside Rg3 on gastric ulcer models in mice

Panacis Quinquefolii Radix: A Review of the Botany, Phytochemistry, Quality Control, Pharmacology, Toxicology and Industrial Applications Research Progress

Pseudo-ginsengenin DQ ameliorated aconitine-induced arrhythmias by influencing Ca2+ and K+ currents in ventricular myocytes

Contact Info

Product

Resources

About

Pseudo-ginsengenin DQ ameliorated aconitine-induced arrhythmias by influencing Ca²⁺ and K⁺ currents in ventricular myocytes