Anti-mycobacterial activity of five plant species used as traditional medicines in the Western Cape Province (South Africa)

Bamuamba, Kapinga; Gammon, David W.; Meyers, Paul R.; Dijoux‐Franca, Marie‐Geneviève; Scott, Gillian

doi:10.1016/j.jep.2008.02.007

Cited by 46 publications

(39 citation statements)

References 19 publications

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“…Due to the rapid emergence of multidrug-resistant strains of Mycobacterium tuberculosis, there is an urgent need to discover a new therapeutics for the treatment of tuberculosis [23]. The antimycobacterial activity of five plant species used in the traditional medicine in South Africa was studied by Bamuamba and coworkers [24] (Table 1). OA present in the extracts of Buddleja saliga (Buddlejaceae) and Leysera gnaphalodes (Asteraceae) exhibited a significant antimycobacterial effect.…”

Section: Antibacterial Activity Of Oa and Its Derivativesmentioning

confidence: 99%

Antibacterial activity of oleanolic and ursolic acids and their derivatives

et al. 2010

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Bacterial resistance to antibiotics is increasing at an alarming rate and many commonly used antibiotics are no longer effective.Thus, there is considerable interest in investigating novel antibacterial compounds, such as the plant-derived pentacyclic triterpenoids, including oleanolic acid (OA), ursolic acid (UA) and their derivatives. These compounds can be isolated from many medicinal and crop plants and their antibacterial, antiviral, antiulcer and anti-inflammatory effects are well documented. OA and UA are active against many bacterial species, particularly Gram-positive species, including mycobacteria. They inhibit bacterial growth and survival, and the spectrum of minimal inhibitory concentration (MIC) values is very broad. In addition, OA, UA and their derivatives display potent antimutagenic activity. Studies to identify the cellular targets and molecular mechanisms of OA and UA action were initiated a few years ago and it has already been demonstrated that both acids influence bacterial gene expression, the formation and maintenance of biofilms, cell autolysis and peptidoglycan turnover. Before these compounds can be used clinically as antimicrobial agents, further extensive studies are required to determine their cytotoxicity and the optimum mode of their application.

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Section: Antibacterial Activity Of Oa and Its Derivativesmentioning

confidence: 99%

Antibacterial activity of oleanolic and ursolic acids and their derivatives

et al. 2010

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“…It is used as a purgative; to treat coughs, colds, diabetes, tuberculosis, thrush and sores, anasarca and chest pains 3,4 . The biological activities reported for B. saligna include antiplasmodial, acetylcholinesterase and alpha-glucosidase inhibitory 2 , anti-mycobacterial 5 , antibacterial and antioxidant 6 , antimutagenic 7 activities. In our previous studies, we reported the interesting antiplasmodial and alpha-glucosidase inhibitory activities exhibited by the hexane fraction of B. saligna 2 .…”

Section: Introductionmentioning

confidence: 99%

Alpha-glucosidase inhibitory and antiplasmodial properties of terpenoids from the leaves ofBuddleja salignaWilld

Chukwujekwu

Rengasamy

Kock

et al. 2015

Journal of Enzyme Inhibition and Medicinal Chemistry

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In our continuing search for biologically active natural product(s) of plant origin, Buddleja saligna, a South African medicinal plant, was screened in line with its traditional use for antidiabetic (yeast alpha glucosidase inhibitory) and antiplasmodial (against a chloroquine sensitive strain of Plasmodium falciparum (NF54)) activities. The hexane fraction showed the most promising activity with regards to its antidiabetic (IC 50 ¼ 260 ± 0.112 mg/ml) and antiplasmodial (IC 50 ¼ 8.5 ± 1.6 mg/ml) activities. Using activity guided fractionation three known terpenoids (betulonic acid, betulone and spinasterol) were isolated from this species for the first time. The compounds displayed varying levels of biological activities (antidiabetic: 27.31 mg/ml ! IC 50 ! 5.6 mg/ml; antiplasmodial: 14 mg/ml ! IC 50 ! 2 mg/ml) with very minimal toxicity.

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“…O5504, SIGMA) is a commonly found triterpenoid in the human diet and in a few medicinal herbs. The antimycobacterial activity of Quinchamalium majus Brongn., Santalaceae [60], Buddleja saligna Willd., Buddlejaceae [60], and Leysera gnaphyloides L., Asteraceae [61] extracts were mainly due to the presence of 103. In 2010, Ge et al reported the synergistic interactions of 103 with commonly used antimycobacterial drugs, while 103 alone showed moderate activity [62].…”

mentioning

confidence: 97%

“…There is a scope for 39 compounds which can be developed as future antimycobacterial drugs. 24,26,33,61,62,65,68,69,83,85,86,[95][96][97][98][116][117][118][119][120]123, and 125-127, with MICs < 10 µg/mL, are comparable to antimycobacterial agents such as INH, RMP, and EMB, and may become future potential antimycobacterial drugs. Compounds 9, 49, 84, and 124, which act as efflux pump inhibitors, may be useful in reversing drug resistance to TB caused by MDR forms.…”

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confidence: 99%