(Anti)mutagenic and immunomodulatory properties of quercetin glycosides

Valentová, Kateřina; Šíma, Petr; Rybková, Zuzana; Křižan, J; Malachová, Kateřina; Křen, Vladimı́r

doi:10.1002/jsfa.7251

Cited by 31 publications

(17 citation statements)

References 45 publications

(80 reference statements)

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“…51 Medicinal plants with antioxidant activity could also have immunomodulatory ability. 50 Our previous research found that a supplement of the extract made from Jatropha curcus leaves in commercially inactivated Newcastle disease vaccines could significantly enhance the immune responses in chickens. 28 One of the herbal plants acts as immunomodulator is S. subprosrate.…”

Section: Discussionmentioning

confidence: 99%

“…Quercetin glycosides were reported as equally effective in suppressing lipid peroxidation in 6-hydroxydopamine-induced pheochromocytoma PC-12 cells as they suppressed the malondialdehyde generation and prevented cell damage. Also, Valentová et al 50 recorded that many quercetin derivatives showed significant antimutagenic activity and DNA-protective effects against oxidative damage. Isoflavones have chemical structures similar to estrogen and so they are sometimes referred to as phytoestrogens.…”

Section: Discussionmentioning

confidence: 99%

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Antioxidant and the Efficacy of Sophora secundiflora and Methoxyisoflavones in the Immune Function of Pigeons Vaccinated against Paramyxovirus Serotype-1

Abd‐Alla¹,

Ibrahim²,

Taie³

et al. 2020

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Objective: The present work investigated the effect of oral administration of hydroalcoholic (70% aqueous ethanol) extract (TeE) of Sophora secundiflora leaves and its organic fractions n-hexane (HeE), ethyl acetate (EaE) and n-butanol (BuE) and major isolated methoxyisoflavones 1 and 2, on the cellular and humoral immune responses to live attenuated avian paramyxovirus-1 (APMV-1) vaccines in pigeons. Methods: The structures of six isolated compounds were elucidated on the basis of chromatographic, chemical, and spectroscopic methods. The samples antioxidative and radical scavenging capabilities of 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azinobis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radical cation and ferric reducing power were determined. Total phenolic, tannin and flavonoid contents of EaE extract were evaluated. Results: Six compounds were isolated. Three were the methoxyisoflavones5-7-dihydroxy-4′-methoxyisoflavone (1), 7-hydroxy-4′methoxyisoflavone (2), 5,4'-dihydroxy-7methoxy-isoflavone (3), along with isorhamnetin (4) and two quercetin derivatives quercetin 3-glucoside (5) and quercetin 3-rutinoside (6) were isolated. The hydroalcoholic extract, fractions and 4'-methoxyisoflavones showed radical scavenging effect in the order of EaE > TeE > BuE >compound 1>compound 2> HeE. Stimulation of both sero-responses was observed, especially this of EaE. The results showed an increase of macrophage cells, lymphocyte and antibody titers in blood. Conclusion: The presence of 5-hydroxyl group at A-ring may be important to show the immunostimulant and antioxidant activity of compound 1vs compound 2. The present results showed the potential abilities of EaE as antioxidant and immunomodulator agent and these would impart healthy economic benefits in vaccinated birds.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Antioxidant and the Efficacy of Sophora secundiflora and Methoxyisoflavones in the Immune Function of Pigeons Vaccinated against Paramyxovirus Serotype-1

Abd‐Alla¹,

Ibrahim²,

Taie³

et al. 2020

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“…These results suggest that the anti-inflammatory activity of horsetail is at least partly mediated by silica and isoquercitrin. Isoquercitrin is a well-known antioxidant [31] with free radical scavenging activity [32]. It shows antiallergic [33] and anti-inflammatory effects in vitro [34,35] as well as in vivo [36].…”

Section: Discussionmentioning

confidence: 99%

In Vitro Anti-inflammatory Effects of Equisetum arvense Are Not Solely Mediated by Silica

et al. 2017

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, known as common horsetail, is used for the treatment of inflammatory diseases and is the plant with the highest concentration of silica. Yet it is unknown if the medicinal properties are mediated by its silica content. In the current study, optimal conditions for silica-rich horsetail preparations were identified. Bioactivity of the preparations was analyzed using flow cytometry-based activity and functionality profiling of primary human lymphocytes as well as cytokine measurement using a classical ELISA technique. Experiments revealed that horsetail preparations suppress activation and proliferation of lymphocytes by an interleukin-2-dependent mechanism. The effect increased with the silica concentration in the decoctions. Lymphocytes' polyfunctionality was also influenced, shown by a downregulation of IFN-. Analytical profiling by HPLC-UV-MS and bioactivity testing revealed relevant immunosuppressive concentrations of a component that has been identified as isoquercitrin. Our results show that both silica and isoquercitrin are active compounds of horsetail preparations.

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“…IM-133N contains extracts of Symplocos recemosa and Prosopis glandulosa , and the LC-MS/MS analysis of IM- 133N showcased the presence of various phytoconstituents, some of which, namely, oleanolic acid [ 21 , 22 ], betulic acid [ 23 ], β -sitosterol [ 22 , 24 ], mesquitol [ 25 ], quercetin [ 22 , 24 , 26 ] and apigenin [ 27 ], are scientifically well demonstrated to have potent IM and anti-oxidant activities; therefore, these phytoconstituents are thought to act through multiple mechanisms, such as anti-oxidant and anti-microbial activities, increases in the expressions of cytokines, and increases in the productions of TNF- α and NO. Furthermore, studies are ongoing to explore the exact mechanism(s) of the action of IM-133N.…”

Section: Discussionmentioning

confidence: 99%

IM-133N - A Useful Herbal Combination for Eradicating Disease-triggering Pathogens in Mice via Immunotherapeutic Mechanisms

Firashathulla

Inamdar

Rafiq³

et al. 2016

J. Pharmacopunct

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Objectives:The present study was undertaken to evaluate the immunomodulatory (IM) activity of IM-133N, a herbal combination in various immunotherapeutic experimental models.Methods:The IM activity of IM-133N was evaluated against three experimental models namely, effect of IM- 133N against Escherichia coli (E. coli)-induced abdominal sepsis in mice, and carbon clearance test was performed in Wistar albino rats to evaluated the phagocytic potential of IM-133N, in addition IM-133N was evaluated for its immunoglobulin enhancing potential in rats, where the immunoglobulin levels were measured by zinc sulphate turbity (ZST) test. Further, IM-133N was subjected for detailed liquid chromatography-mass spectrometry (LC-MS)/MS analysis to identify the probable active constituents present in it.Results:The findings of the present study has demonstrated very promising IM property of IM-133N in all the experimental models. Briefly, pretreatment with IM-133N at 125, 250, 500 and 1,000 mg/kg, p.o. doses had protected the mice against E. coli-induced abdominal sepsis and mortality, further the effect of IM- 133N was found to be significant and dose-dependent. In support of this, in another study administration of IM-133N showed a significant and dose-dependent increase in serum immunoglobulin levels, estimated by ZST test. In line with the above findings, in the carbon clearance test the low doses (125 and 250 mg/ kg, p.o.) of IM-133N increased the rate of carbon clearance, whereas the higher doses (500 and 1,000 mg/kg, p.o.) did not sustain the response, and saturation effect was considered as one of the possible reason for futility of higher doses for IM-133N. In addition, A detailed LC-MS/MS analysis of IM-133N showed 17 bioactive phytochemical constituents: namely, apigenin, chaulmoogric acid, mesquitol, quercetin, symphoxanthone, salireposide, β-sitosterol, nonaeicosanol, β-amyrin, betulic acid, oleanolic acid, symplososide, symponoside, symploveroside, symplocomoside, symconoside A and locoracemoside B.Conclusion:These findings suggest that IM-133N possesses significant IM activity and, hence, could be useful for eradicating opportunistic disease-triggering pathogens via immunotherapeutic mechanisms. The findings also suggest IM-133N may also useful in other immunity disorders.

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(Anti)mutagenic and immunomodulatory properties of quercetin glycosides

Abstract: Isoquercitrin displayed negligible and rutin no mutagenicity, but both showed significant antimutagenic and DNA-protective effects against oxidative damage. In vivo, they supported the readiness of the immune system for specific humoral immune response.

Cited by 31 publications

References 45 publications

Antioxidant and the Efficacy of Sophora secundiflora and Methoxyisoflavones in the Immune Function of Pigeons Vaccinated against Paramyxovirus Serotype-1

Antioxidant and the Efficacy of Sophora secundiflora and Methoxyisoflavones in the Immune Function of Pigeons Vaccinated against Paramyxovirus Serotype-1

In Vitro Anti-inflammatory Effects of Equisetum arvense Are Not Solely Mediated by Silica

IM-133N - A Useful Herbal Combination for Eradicating Disease-triggering Pathogens in Mice via Immunotherapeutic Mechanisms

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