Anti-Müllerian hormone reflects the severity of polycystic ovary syndrome

Jacob, Susie; Field, H P; Calder, Nicole; Picton, HM; Balen, Adam; Barth, Julian H.

doi:10.1111/cen.13269

Cited by 31 publications

(16 citation statements)

References 36 publications

(72 reference statements)

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“…Testosterone is secreted from the adrenal glands (25%), the ovaries (25%), and from the peripheral conversion of androstenedione (50%) . AMH is secreted from the ovary and is a more sensitive marker of PCOM/PCOS than USG and was significantly increased in the persistent acne group (Table ) which is consistent with the preponderance of PCOS in this group (Table ).…”

Section: Discussionsupporting

confidence: 72%

A study comparing the clinical and hormonal profile of late onset and persistent acne in adult females

et al. 2020

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Background Adult acne has been classified into two major subtypes: “persistent acne” and “late onset acne”. A surrogate marker of hyperandrogenism (HA) in adult female acne is the presence of clinical signs of HA and biochemical hyperandrogenemia. We compared the clinical and hormonal profiles of the two acne subtypes and evaluated the likely source of androgen excess – ovarian or adrenal. Methods Female acne patients 25 years of age and older were evaluated for clinical HA. Hormonal assessment included total testosterone (TT), sex hormone binding globulin (SHBG), free androgen index (FAI), anti‐Mullerian hormone (AMH), 17‐hydroxyprogesterone (17‐OHP), dehydroepiandrosterone sulfate (DHEAS), follicle stimulating hormone (FSH), luteinizing hormone (LH), thyroid stimulating hormone (TSH), and prolactin. DHEAS and 17‐OHP represented adrenal androgens and AMH indicated ovarian reserve. Results Of 120 cases, clinical HA was seen in 71.67% while biochemical hyperandrogenemia was detected in only 18.33% of patients. Though late onset was more common in adult acne patients (56.6%), the persistent acne subgroup (43.33%) had a younger age at onset, a past history of adolescent acne (51.92%), truncal predilection (44.23%), polycystic ovary syndrome (PCOS) (44.23%), significant presence of irregular menses (40.38%) and hirsutism (57.69%), and increased TT (13.46%), 17‐OHP (76.92%), AMH (44.23%), and increased LH/FSH (15.38%) ratio. PCOS was seen more in the persistent acne patients with clinical HA and increased 17‐OHP levels. Conclusion Persistent acne patients had marked clinical HA, PCOS, and hormonal abnormalities necessitating an endocrinological evaluation. As a corollary, this subgroup would benefit from antiandrogen therapy.

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Section: Discussionsupporting

confidence: 72%

A study comparing the clinical and hormonal profile of late onset and persistent acne in adult females

et al. 2020

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“…In PCOS with high androgen, serum AMH levels increase significantly compared with PCOS with normal androgen [27]. Others suggest that serum AMH level is related to the severity of PCOS [34,35]. Such an interaction may contribute to the pathogenesis of PCOS [28].…”

Section: Discussionmentioning

confidence: 99%

Role of anti-Müllerian hormone and testosterone in follicular growth: a cross-sectional study

Jin

Rao

et al. 2020

BMC Endocr Disord

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Background: Anti-Müllerian hormone (AMH) is now considered the best serum biomarker of ovarian reserve, while basal sex hormones are classic markers used for assessing ovarian reserve. The interaction between AMH and sex hormones are complicated and not sufficiently addressed. In this study, we took diminished ovarian reserve (DOR) and polycystic ovarian syndrome (PCOS) as two extremes of ovarian reserve (deficient and excessive respectively) to investigate the role of AMH and sex hormones in follicular growth. Methods: A retrospective cross-sectional survey was performed. The patients assessed AMH and basal sex hormones in the Second Hospital of Zhejiang University from April 2016 to March 2019 were involved in this study. Serum AMH and sex hormone concentrations were tested with electrochemiluminescence method. Stepwise linear regression and binary logistic regression was used to determine the predictors of AMH level and to explore the involved factors determining DOR and PCOS. Results: In the present study, we found that age and follicle-stimulating hormone (FSH) were main negative correlation factors, and luteinizing hormone (LH) and testosterone (T) were main positive factors of AMH. In DOR group, age, FSH and estradiol (E 2) increased and T decreased, while in PCOS group, LH and T increased. Binary logistic regression found that age, weight, FSH, E 2 , and T were the significant factors which independently predicted the likelihood of DOR, and that age, body mass index (BMI), AMH, LH, and T predicted the likelihood of PCOS. Conclusions: Our study demonstrated that age, FSH, and T were factors that most closely correlated with AMH level, and T was involved in both DOR and PCOS. Since DOR and PCOS are manifested with insufficient AMH and excessive AMH respectively, it is suggested that total testosterone correlated with AMH closely and plays an important role in follicular growth. More attention should be given to testosterone level during controlled ovarian hyperstimulation (COH) process.

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“…16 It would be advantageous if AMH can replace the use of transvaginal ultrasound given the complexity, cost, inter-observer variation involved in the determination of AFC and OV. 6,17,18 The strong correlation that has been reported between PCOS and AMH by a multitude of studies, [19][20][21] has even lead to the view that AMH alone, may be a suitable as a single biomarker for PCOS. Nevertheless, there is a lack of studies examining the performance of various proposed criteria compared to the Rotterdam 2003 criteria.…”

Section: Introductionmentioning

confidence: 99%