Anti-Müllerian hormone levels as a predictor of the pregnancy rate in women of advanced reproductive age

Şahmay, Sezai; Öncül, Mahmut; Tüten, Abdullah; Tok, Abdullah; Açıkgöz, Aydan; Çepni, İsmail

doi:10.1007/s10815-014-0324-y

Cited by 23 publications

(24 citation statements)

References 26 publications

(32 reference statements)

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“…Although some studies have reported that AMH can be a predictor of the ovarian reserve and the success rate of IVF,20, 21 this study's findings are consistent with those of other studies 22, 23…”

Section: Discussionsupporting

confidence: 90%

Pregnancy outcomes after assisted reproductive procedures with embryos that had been derived from affected and unaffected ovaries among women with small unilateral endometriomas

Takashima

Takeshita

Kinoshita

2017

Reprod Medicine & Biology

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AimTo clarify the effects of small endometriomas on in vitro fertilization (IVF) outcomes. In the present study, the potential impact of small ovarian endometriomas on the quantitative and qualitative outcomes of IVF was evaluated in the same individual.MethodsA retrospective analysis was performed, in which 118 infertile women with unilateral endometriomas that were <40 mm in size and who underwent IVF or intracytoplasmic sperm injection were evaluated. Single frozen embryo transfer cycles were performed, with separate data collections for both the affected and the unaffected ovaries, which allowed for an evaluation of the implantation rate.ResultsThe mean antral follicular count and the number of follicular flushings, retrieved oocytes, and obtained embryos were significantly lower for the endometrioma‐containing ovary than for the contralateral, intact ovary. No significant difference was observed regarding the blastocyst retrieval and good‐quality blastocyst retrieval rates, pregnancy rate, and clinical pregnancy or live birth rate.ConclusionAlthough the patients with a small endometrioma had a decreased ovarian reserve, they had lower pregnancy rates. The decision to transfer an embryo from an endometrioma‐containing ovary or from a contralateral, intact ovary also might not influence the pregnancy rate.

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Section: Discussionsupporting

confidence: 90%

Pregnancy outcomes after assisted reproductive procedures with embryos that had been derived from affected and unaffected ovaries among women with small unilateral endometriomas

Takashima

Takeshita

Kinoshita

2017

Reprod Medicine & Biology

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“…Some studies have associated higher AMH concentrations (Kamel et al 2014, Sahmay et al 2014 and AFC (Holte et al 2011) with higher pregnancy rates in women undergoing reproductive treatments. However, longitudinal studies on plasma AMH at the prepubertal age and its implications in later reproductive life in girls and domestic animals are scarce.…”

Section: Discussionmentioning

confidence: 99%

Postnatal pituitary and follicular activation: a revisited hypothesis in a sheep model

Torres-Rovira¹,

Succu²,

Pasciu³

et al. 2016

Reproduction

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The importance of postnatal pituitary activation as regards female reproductive development is not yet understood. By taking advantage of the experimental model developed in a previous study, i.e. ewe lambs expressing markedly different ovarian phenotypes at 50 days of age, we designed this study to determine whether differences found in ovarian status during the early prepubertal period are due to different patterns of postnatal pituitary activation, and to assess whether these differences have long lasting effects on subsequent reproductive performance. Results showed that ewe lambs with high antral follicle count (AFC) at 50 days of age had significantly lower plasma FSH concentrations and higher anti-Mullerian hormone (AMH) concentrations during the first 9 weeks of age compared with low AFC ewe lambs (P!0.0001). With a longitudinal experiment we showed that a high AFC in the early prepubertal period is associated with consistently higher AMH concentrations and numbers of antral follicles up to the postpubertal period, and with higher pregnancy rates in the first breeding season. In addition, the effect of age in decreasing AMH concentrations was more marked in the low AFC group. Results of the present study demonstrate that ewe lambs undergo different patterns of postnatal pituitary activation. A high AFC at 50 days of age indicates an advanced phase of ovarian maturation, which was accompanied by constantly higher AMH concentrations up to the postpubertal period, a greater ovarian response to FSH stimulation and by higher pregnancy rates at first mating, as compared with the low AFC group.

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“…This is due to in part the declining ovarian reserve as evidenced by low levels of anti-Mullerian hormone (AMH) and antral follicular counts (AFC) which are proxy indicators of the ovarian reserve [13]. Both of our patients had AMH levels in the low fertility range.…”

Section: Discussionmentioning

confidence: 78%

Childbearing at very advanced maternal age, the challenges and complications: A report of two cases

Oindi¹,

Sequeira²,

Mutiso³

2017

IJCRI

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International Journal of Case Reports and Images (IJCRI) is an international, peer reviewed, monthly, open access, online journal, publishing high-quality, articles in all areas of basic medical sciences and clinical specialties.Aim of IJCRI is to encourage the publication of new information by providing a platform for reporting of unique, unusual and rare cases which enhance understanding of disease process, its diagnosis, management and clinico-pathologic correlations. The desire for childbearing at very advanced maternal age (maternal age ≥45 years at the time of delivery) is becoming increasingly common. This has resulted in increased demand and utilization of assisted reproductive technologies to counteract the declining fecundity associated with the advanced maternal age. However, the older gravidas are at increased risk of having various medical conditions with potential adverse impact on their pregnancies making such pregnancies be considered as high risk pregnancies. Case Report: We present two cases of very advanced maternal age pregnancies (54-year-old and 49-year-old), both conceived through assisted reproductive technology, we successfully managed through their pregnancies outlining the conception challenges, pregnancy complications and the subsequent management and outcomes. We further undertake a literature review to assess the challenges and outcomes of pregnancies at very advanced maternal age. Conclusion: Childbearing at very advanced maternal age is challenging from conception to delivery. Owing to the age related decline in fertility, most of these women require assisted reproductive technology (ART). Moreover, they are more likely to have adverse pregnancy outcomes principally stemming from preterm births with a resultant greater maternal and perinatal mortality and morbidity. With the increasing trend towards delayed child bearing, and owing to the anticipated adverse pregnancy outcomes, the hospitals and physicians needs to equip themselves for the increased demand for ART and the need for sophisticated prenatal, perinatal and postpartum care. IJCRI publishes

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Anti-Müllerian hormone levels as a predictor of the pregnancy rate in women of advanced reproductive age

Cited by 23 publications

References 26 publications

Pregnancy outcomes after assisted reproductive procedures with embryos that had been derived from affected and unaffected ovaries among women with small unilateral endometriomas

Pregnancy outcomes after assisted reproductive procedures with embryos that had been derived from affected and unaffected ovaries among women with small unilateral endometriomas

Postnatal pituitary and follicular activation: a revisited hypothesis in a sheep model

Childbearing at very advanced maternal age, the challenges and complications: A report of two cases

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