Anti-Müllerian Hormone Concentrations in Premenopausal Women and Breast Cancer Risk

Nichols, Hazel B.; Baird, Donna D.; Stanczyk, Frank Z.; Steiner, Anne Z.; Troester, Melissa A.; Whitworth, Kristina W.; Sandler, Dale P.

doi:10.1158/1940-6207.capr-14-0377

Cited by 26 publications

(43 citation statements)

References 33 publications

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“…Women selected for this analysis participated as controls in a nested case-control study of AMH and breast cancer risk that has been previously described (4). Briefly, to be eligible for selection in to the case-control study, Sister Study participants were required to be ages 35–54 at time of enrollment, have an archived serum sample, at least 1 intact ovary, and be categorized as premenopausal (4).…”

Section: Methodsmentioning

confidence: 99%

“…Briefly, to be eligible for selection in to the case-control study, Sister Study participants were required to be ages 35–54 at time of enrollment, have an archived serum sample, at least 1 intact ovary, and be categorized as premenopausal (4). Premenopausal status was defined as reporting at least one menstrual cycle in the 12 months prior to study enrollment.…”

Section: Methodsmentioning

confidence: 99%

“…Ovarian reserve testing can provide information to inform fertility-related clinical treatment decisions; for example, AMH correlates with IVF success rates (2). Additionally, higher AMH levels have been associated with increasing time to menopause (3) and breast cancer risk (4, 5). …”

Section: Introductionmentioning

confidence: 99%

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Antimüllerian hormone in relation to tobacco and marijuana use and sources of indoor heating/cooking

White

Sandler

D’Aloisio

et al. 2016

Fertility and Sterility

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Objective To evaluate exposure to tobacco, marijuana and indoor heating/cooking sources in relation to anti-Müllerian hormone (AMH) levels. Design Cross-sectional analysis in a sample of premenopausal women (N=913) enrolled in the Sister Study cohort (n=50,884). Setting U.S. adult sample Patient(s) Women, 35–54 at time of enrollment, with an archived serum sample, at least 1 intact ovary, and classified as premenopausal. Intervention(s) Not applicable Main Outcome Measures Serum AMH (ng/ml) levels ascertained by ultrasensitive ELISA assay Results Lower AMH levels were associated with sources of indoor heating, including burning wood (−36.0%, 95%CI:−55.7, −7.8%) or artificial firelogs (−45.8%, 95%CI:−67.2, −10.4) at least 10 times/year in a residential indoor stove/fireplace. Lower AMH levels were also observed in women who were current smokers of ≥20 cigarettes/day relative to non-smokers (−56.2%, 95%CI:−80.3, −2.8%) and in women with 10+ years of adult environmental tobacco smoke (ETS) exposure (−31.3%, 95%CI:−51.3, −3.1%) but no associations were observed for marijuana use. Conclusions We confirmed previously reported findings of lower AMH levels in current heavy smokers and also found associations for long-term ETS exposure and indoor burning of wood or artificial firelogs. These findings suggest that combustion by-products from common exposures can have toxic effects on the human ovary.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Antimüllerian hormone in relation to tobacco and marijuana use and sources of indoor heating/cooking

White

Sandler

D’Aloisio

et al. 2016

Fertility and Sterility

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“…The first prospective analysis to evaluate this association (n=105 cases, 204 controls) showed a strong positive association between serum AMH levels and breast cancer risk (p-trend <0.001) (14). These findings were recently supported by two case-control studies nested within the Sister Study cohort (n=452 cases, 902 controls) (15) and the Nurses’ Health Study II (n=539 cases, 471 controls) (16), both of which also demonstrated a significant positive association between AMH concentrations and breast cancer risk, with a more than 2-fold increased risk among women with the highest AMH concentrations compared to those with AMH <LOD.…”

Section: Discussionmentioning

confidence: 72%

“…Another study of 10 normal weight and 10 obese ovulatory young women between ages 18 and 35, AMH levels were 34% lower in the obese group (17). AMH levels peak in the mid-20s and subsequently decline with age, becoming non-detectable by menopause (15, 19, 56, 57). Since participants in the DISC06 Follow-up Study were ages 25–29 and consequently had relatively high AMH concentrations, there may have been insufficient variation at low concentrations in AMH levels to observe associations with current or earlier life BMI.…”

Section: Discussionmentioning

confidence: 99%

Early Life Body Fatness, Serum Anti-Müllerian Hormone, and Breast Density in Young Adult Women

Bertrand

Baer

Orav

et al. 2016

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background Emerging evidence suggests positive associations between serum antimüllerian hormone (AMH), a marker of ovarian function, and breast cancer risk. Body size at young ages may influence AMH levels, but few studies have examined this. Also, no studies have examined the relation of AMH levels with breast density, a strong predictor of breast cancer risk. Methods We examined associations of early life body fatness, AMH concentrations, and breast density among 172 women in the Dietary Intervention Study in Children (DISC). Height and weight were measured at baseline (ages 8–10) and throughout adolescence. Serum AMH concentrations and breast density were assessed at ages 25–29 at the DISC06 Follow-Up visit. We used linear mixed effects models to quantify associations of AMH (dependent variable) with quartiles of age-specific youth body mass index (BMI) Z-scores (independent variable). We assessed cross-sectional associations of breast density (dependent variable) with AMH concentration (independent variable). Results Neither early life BMI nor current adult BMI was associated with AMH concentrations. There were no associations between AMH and percent or absolute dense breast volume. In contrast, women with higher AMH concentrations had significantly lower absolute non-dense breast volume (p-trend <0.01). Conclusions We found no evidence that current or early life BMI influences AMH concentrations in later life. Women with higher concentrations of AMH had similar percent and absolute dense breast volume, but lower non-dense volume. Impact These results suggest that AMH may be associated with lower absolute non-dense breast volume; however, future prospective studies are needed to establish temporality.

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Circulating anti‐Müllerian hormone and breast cancer risk: A study in ten prospective cohorts

Clendenen

Afanasyeva

et al. 2018

Intl Journal of Cancer

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A strong positive association has been observed between circulating anti-Müllerian hormone (AMH), a biomarker of ovarian reserve, and breast cancer risk in three prospective studies. Confirming this association is important because of the paucity of biomarkers of breast cancer risk in premenopausal women. We conducted a consortium study including ten prospective cohorts that had collected blood from premenopausal women. A nested case-control design was implemented within each cohort. A total of 2,835 invasive (80%) and in situ (20%) breast cancer cases were individually matched to controls (n = 3,122) on age at blood donation. AMH was measured using a high sensitivity enzyme-linked immunoabsorbent assay. Conditional logistic regression was applied to the aggregated dataset. There was a statistically significant trend of increasing breast cancer risk with increasing AMH concentration (p across quartiles <0.0001) after adjusting for breast cancer risk factors. The odds ratio (OR) for breast cancer in the top vs. bottom quartile of AMH was 1.60 (95% CI = 1.31-1.94). Though the test for interaction was not statistically significant (p = 0.15), the trend was statistically significant only for tumors positive for both estrogen receptor (ER) and progesterone receptor (PR): ER+/PR+: OR = 1.96, 95% CI = 1.46-2.64, p <0.0001; ER+/PR-: OR = 0.82, 95% CI = 0.40-1.68, p = 0.51; ER-/PR+: OR = 3.23, 95% CI = 0.48-21.9, p = 0.26; ER-/PR-: OR = 1.15, 95% CI = 0.63-2.09, p = 0.60. The association was observed for both pre- (OR = 1.35, 95% CI = 1.05-1.73) and post-menopausal (OR = 1.61, 95% CI = 1.03-2.53) breast cancer (p = 0.34). In this large consortium study, we confirmed that AMH is associated with breast cancer risk, with a 60% increase in risk for women in the top vs. bottom quartile of AMH.

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Anti-Müllerian Hormone Concentrations in Premenopausal Women and Breast Cancer Risk

Cited by 26 publications

References 33 publications

Antimüllerian hormone in relation to tobacco and marijuana use and sources of indoor heating/cooking

Antimüllerian hormone in relation to tobacco and marijuana use and sources of indoor heating/cooking

Early Life Body Fatness, Serum Anti-Müllerian Hormone, and Breast Density in Young Adult Women

Circulating anti‐Müllerian hormone and breast cancer risk: A study in ten prospective cohorts

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