Anti-Mullerian hormone and antral follicle count as predictors of ovarian reserve and successful IVF

Abdelazim, Ibrahim A.; Belal, Maha M.; Makhlouf, Hanan H.

doi:10.1016/s2305-0500(13)60055-x

Cited by 5 publications

(3 citation statements)

References 16 publications

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“…Recently, Venturella et al . has concluded that OvAge is one of the first reliable attempts to create a new method able to identify ovarian reserve [ 32 , 33 ].…”

Section: Discussionmentioning

confidence: 99%

Ovarian function and ovarian blood supply following premenopausal abdominal hysterectomy

Abdelazim¹,

Abdelrazak²,

Elbiaa³

et al. 2015

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IntroductionThe issue of conserving the ovaries at hysterectomy in premenopausal women with benign gynecologic disease has been the subject of considerable controversy. Some clinicians prefer prophylactic oophorectomy in premenopausal women during hysterectomy to prevent future development of malignant changes in conserved ovaries. Other clinicians prefer to conserve apparently normal ovaries, because bilateral oophorectomy in premenopausal women results in an abrupt imbalance, sudden onset of menopausal symptoms, decreased libido, increased cardiovascular risk and osteoporosis.Material and methodsTwo hundred and twenty multipara women (who had completed their families), with benign uterine pathology were included in this prospective study for abdominal hysterectomy with bilateral ovarian preservation. Pre-operative vaginal ultrasound, Doppler studies, diagnostic hysteroscopy and endometrial biopsy were done followed by laboratory studies including Anti-mullerian hormone (AMH), follicle stimulating hormone (FSH) and estradiol for all studied women. Doppler studies, AMH, FSH and estradiol were repeated 6 and 12 months post-operative for assessment of the ovarian function and ovarian blood supply after hysterectomy.ResultsPre-operative AMH, FSH and estradiol of the studied women were statistically insignificant compared to AMH, FSH and estradiol 6 and 12 months post-operative. Twelve months post-operative right and left ovarian volumes (6.92 ± 0.18 and 6.85 ± 0.19 cm3, respectively) were significantly larger than pre-operative right and left ovarian volumes (6.19 ± 0.22 and 5.86 ± 0.23 cm3, respectively), and, 12 months post-operative right and left ovarian pulsatility indices (2.92 ± 0.15 and 2.96 ± 0.16 cm/s, respectively) were significantly lower than pre-operative right and left ovarian pulsatility indices (3.45 ± 0.19 and 3.36 ± 0.2 cm/s, respectively). Eight (3.6%) cases of the studied women developed an ovarian cyst 6 months after hysterectomy, 3 were spontaneously resolved and the remaining 5 (2.27%) cases underwent exploratory laparotomy.ConclusionsThere is no evidence of ovarian dysfunction affecting conserved ovaries one year after hysterectomy in premenopausal women as evident by AMH, FSH and estradiol. Furthermore, an increased ovarian volume and reduced ovarian pulsatility indices indicate a possible increase in ovarian blood supply, and preserved non-compromised ovarian function.

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“…Recently, Venturella et al . has concluded that OvAge is one of the first reliable attempts to create a new method able to identify ovarian reserve [ 32 , 33 ].…”

Section: Discussionmentioning

confidence: 99%

Ovarian function and ovarian blood supply following premenopausal abdominal hysterectomy

Abdelazim¹,

Abdelrazak²,

Elbiaa³

et al. 2015

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“…The AMH is gonadotropins independent and its assay can be done at any time of the menstrual cycle. The AMH levels below 1 ng/ml are associated with DOR [24].…”

Section: Prediction Of Primary Ovarian Insufficiencymentioning

confidence: 99%

Primary ovarian insufficiency and fertility preservation: review article

Purohit¹,

Savvas²,

Abdelazim³

et al. 2018

jogi

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Introduction: Female fertility and the ovarian reserve decrease with age. Material and methods: Review of literature about the primary ovarian insufficiency (POI) and methods of fertility preservation to define women at risk of POI and their fertility saving options. Results: Women with a family history of POI, fragile X syndrome primary ovarian insufficiency mutation (FXPOI), autoimmune thyroiditis, Addison's disease, exposure to toxins and viral infection are at high risk of POI. In-vitro-fertilization success improved after introduction of oocyte (or embryo) vitrification. Transplantation of the cryo-preserved ovarian tissue could be a fertility preservation option. Transplantation of the cryo-preserved ovarian tissue is an outpatient procedure, which restores hormonal function and fertility. After ovarian tissue transplantation women can conceive normally without medical assistance. Conclusions: The use of donor oocytes is the only treatment for women at risk of POI. The in-vitro-fertilization outcome improved after introduction of oocyte (or embryo) vitrification. Transplantation of the cryo-preserved ovarian tissue is an outpatient procedure, which restores hormonal function and fertility.

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“…Serum AMH Level: AMH secreted by follicular granulosa cells, gonadotropin-independent and therefore can be measured in any day of the cycle [26][27][28][29][30][31]. AMH decreased with external use of contraceptive pills or gonadotrophic releasing hormones (GnRH), and hypogonadotropic hypogonadism [32][33][34][35].…”

Section: Evaluation Of the Ovarian Reservementioning

confidence: 99%