Anti-Müllerian hormone (AMH) is a strong predictor of live birth in women undergoing assisted reproductive technology

Łukaszuk, Krzysztof; Liss, Joanna; Kunicki, Michał; Jakiel, Grzegorz; Waśniewski, Tomasz; Wocławek-Potocka, Izabela; Pastuszek, Ewa

doi:10.1016/j.repbio.2014.03.004

Cited by 53 publications

(37 citation statements)

References 25 publications

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“…We found no signi cant differences in the rates of normal and abnormal blastocysts screened in women younger or older than 35 years with either method. However, a signi cant increase in aneuploidy was previously observed in women > 39-years-of-age [12], and another study reported the lowest aneuploidy rate in women 26-37years-of-age, increasing to 33% at age 42 and 53% at age 44 [13]. In our study, only 10 blastocysts were analysed in women aged 35-40 years old, suggesting the possibility of bias.…”

Section: Discussioncontrasting

confidence: 60%

Validation of Next-Generation Sequencing and Array Comparative Genomic Hybridization for Diagnosis and Screening of Reciprocal and Robertsonian Translocations in Human Blastocysts

Yuan

Sun

et al. 2020

Preprint

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Background: Advances in biotechnology, especially next-generation sequencing (NGS) and array comparative genomic hybridization (aCGH) approaches, have improved preimplantation genetic screening; however, these methods have not been directly compared. This study was carried out to identify the more promising method for screening reciprocal and Robertsonian translocations. Here, blastocysts from carriers with reciprocal and Robertsonian translocations were retrospectively evaluated and results from preimplantation genetic testing in 272 blastocytes were analysed for parental unbalanced translocations using aCGH and NGS. Results: There was no significant difference in the no embryo-transfer rate between aCGH and NGS. Among 59 blastocysts screened in the aCGH group, 32.76% were normal embryos and 67.24% were abnormal embryos, including 36.21% embryos with a translocation, 17.24% with no translocation, and 15.52% with combined abnormalities. Similar results were obtained from the 214 blastocysts tested in the NGS group. In women <35-years, more normal blastocysts were identified in the NGS group compared to the aCGH group. There was a higher rate of euploidy among blastocysts with higher quality grades in the NGS group than in the aCGH group for the trophectoderm (43.51% vs 29.41%) and inner cell mass (59.11% vs 25.00%). Conclusion: Equivalent clinical findings were observed for aCGH and NGS for parental reciprocal chromosomal translocations. However, NGS has the potential to overcome the inherent limitations of aCGH, including the detection of mosaicism and smaller partial gains/losses, thereby providing improvements in the detection of euploid blastocysts, along with enhanced reliability and sensitivity.

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Section: Discussioncontrasting

confidence: 60%

Validation of Next-Generation Sequencing and Array Comparative Genomic Hybridization for Diagnosis and Screening of Reciprocal and Robertsonian Translocations in Human Blastocysts

Yuan

Sun

et al. 2020

Preprint

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“…Findings from several large-scale retrospective analyses of women undergoing IVF found a positive association between AMH level and live birth rates (Arce et al, 2013b;Khader et al, 2013;Li et al, 2013;Lukaszuk et al, 2014). A recent prospective study in nearly 900 women undergoing 1230 IVF cycles confirmed these findings, reporting that AMH level is strongly associated with both pregnancy and live birth rates, independent of age and oocyte yield (Brodin et al, 2013).…”

Section: Amh: the Evidence As A Predictive Methodsmentioning

confidence: 87%

“…Reports examining the correlation with clinical pregnancy rate and live birth rate, however, are more variable (Chang et al, 1998a(Chang et al, , 1998bHsu et al, 2011;Jayaprakasan et al, 2012;Lukaszuk et al, 2014), and AFC has not been shown to be predictive of embryo quality (Chang et al, 1998a(Chang et al, , 1998bHsu et al, 2011;Jayaprakasan et al, 2012). It has also been suggested that determination of AFC may be helpful in identifying an appropriate stimulation protocol (Hsu et al, 2011).…”

Section: Afc: the Evidence As A Predictive Methodsmentioning

confidence: 99%

Assessing ovarian response: antral follicle count versus anti-Müllerian hormone

Fleming¹,

Seifer

Frattarelli³

et al. 2015

Reproductive BioMedicine Online

227

148

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“…Anti-Müllerian Hormone (AMH) is a marker of ovarian reserve, as serum AMH levels reflect the ovarian follicular pool (1). Ovarian reserve testing can provide information to inform fertility-related clinical treatment decisions; for example, AMH correlates with IVF success rates (2). Additionally, higher AMH levels have been associated with increasing time to menopause (3) and breast cancer risk (4, 5).…”

Section: Introductionmentioning

confidence: 99%

Antimüllerian hormone in relation to tobacco and marijuana use and sources of indoor heating/cooking

White

Sandler

D’Aloisio

et al. 2016

Fertility and Sterility

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Objective To evaluate exposure to tobacco, marijuana and indoor heating/cooking sources in relation to anti-Müllerian hormone (AMH) levels. Design Cross-sectional analysis in a sample of premenopausal women (N=913) enrolled in the Sister Study cohort (n=50,884). Setting U.S. adult sample Patient(s) Women, 35–54 at time of enrollment, with an archived serum sample, at least 1 intact ovary, and classified as premenopausal. Intervention(s) Not applicable Main Outcome Measures Serum AMH (ng/ml) levels ascertained by ultrasensitive ELISA assay Results Lower AMH levels were associated with sources of indoor heating, including burning wood (−36.0%, 95%CI:−55.7, −7.8%) or artificial firelogs (−45.8%, 95%CI:−67.2, −10.4) at least 10 times/year in a residential indoor stove/fireplace. Lower AMH levels were also observed in women who were current smokers of ≥20 cigarettes/day relative to non-smokers (−56.2%, 95%CI:−80.3, −2.8%) and in women with 10+ years of adult environmental tobacco smoke (ETS) exposure (−31.3%, 95%CI:−51.3, −3.1%) but no associations were observed for marijuana use. Conclusions We confirmed previously reported findings of lower AMH levels in current heavy smokers and also found associations for long-term ETS exposure and indoor burning of wood or artificial firelogs. These findings suggest that combustion by-products from common exposures can have toxic effects on the human ovary.

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Anti-Müllerian hormone (AMH) is a strong predictor of live birth in women undergoing assisted reproductive technology

Cited by 53 publications

References 25 publications

Validation of Next-Generation Sequencing and Array Comparative Genomic Hybridization for Diagnosis and Screening of Reciprocal and Robertsonian Translocations in Human Blastocysts

Validation of Next-Generation Sequencing and Array Comparative Genomic Hybridization for Diagnosis and Screening of Reciprocal and Robertsonian Translocations in Human Blastocysts

Assessing ovarian response: antral follicle count versus anti-Müllerian hormone

Antimüllerian hormone in relation to tobacco and marijuana use and sources of indoor heating/cooking

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