Anti muellerian hormone serum levels in women with endometriosis: A case-control study

Shebl, Omar; Ebner, Thomas; Sommergruber, Michael; Sir, Andreas; Tews, G

doi:10.1080/09513590903159615

Cited by 23 publications

(22 citation statements)

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“…Other benign diseases, such as recurrent ovarian endometriosis or recurrent ovarian mucinous cysts, are also indications for OTC, even if these indications have become questionable in the light of recent studies. Severe endometriosis is known to be associated with decreased oocyte quality [6] and lower serum antiMüllerian hormone (AMH) concentrations [55]. This corroborates one of our studies in which endometriotic ovarian cysts were described as a possible cause of reduced ovarian reserve in women with endometriosis [29].…”

Section: Incidence Of Indications and Comparison With Other Reportssupporting

confidence: 86%

A review of 15 years of ovarian tissue bank activities

Dolmans

Jadoul

Gilliaux

et al. 2013

J Assist Reprod Genet

109

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Purpose To review 15 years of activities in ovarian tissue cryobanking from medical database files, including patient indications, histological evaluation and clinical characteristics. Methods Retrospective longitudinal analysis of data from an ovarian tissue bank in an academic hospital. Five hundred and eighty-two patients had their ovarian tissue cryobanked between April 1997 and January 2012. Analysis of cryobanking database: precryopreservation patient characteristics, indications and safety issues, laboratory files and postcryopreservation clinical data. Results Of the 582 patients who had their ovarian tissue cryopreserved, 106 patients donated for research purposes and 476 patients for fertility preservation and long-term cryopreservation. Clinical data analysis of the 476 patients revealed a mean age at the time of cryopreservation of 23± 8.5 years (range: 9 months -39 years), with 96.2 % of subjects aged ≤35 years (n=458). Among 391 cases of malignant disease, hematological malignancies (39.9 %, n=156) and breast cancer (21.7 %, n=85) were the two main indications.At histology, malignant cells were found in ovarian tissue from leukemia patients (n = 3) and non-Hodgkin's lymphoma patients (n=2). Eleven patients underwent autotransplantation, resulting in 5 live births and 1 ongoing pregnancy. Conclusion This is the largest and most comprehensive study to describe and analyze indications and clinical patient characteristics before and after ovarian tissue cryopreservation. The procedure is safe, easy and promising. The database concept is a useful tool in patient selection for autotransplantation.

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Section: Incidence Of Indications and Comparison With Other Reportssupporting

confidence: 86%

A review of 15 years of ovarian tissue bank activities

Dolmans

Jadoul

Gilliaux

et al. 2013

J Assist Reprod Genet

109

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“…Lower anti-mullerian hormone serum levels and an association with the severity were found in women with endometriosis. This information might be useful in patients, especially those with severe endometriosis undergoing controlled ovarian stimulation (1). Putative serum markers (monocyte chemoattractant protein 1, migration inhibitory factor, leptin, and CA-125) improved their diagnostic capability to 73% of patients, with 94% overall accuracy (2).…”

Section: Diagnosismentioning

confidence: 99%

Ovarian cystectomy in endometriomas: Combined approach

Ünlü

Yıldırım

2014

J Turkish German Gynecol Assoc

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Endometrioma is one of the most frequent adnexal masses in the premenopausal population, but the recommended treatment is still a subject of debate. Medical therapy is inefficient and can not be recommended in the management of ovarian endometriomas. The general consensus is that ovarian endometriomas larger than 4 cm should be removed, both to reduce pain and to improve spontaneous conception rates. The removal of ovarian endometriomas can be difficult, as the capsule is often densely adherent. While the surgical treatment of choice is surgical laparoscopy, for conservative treatment, the preferred method is modified combined cystectomy. Cystectomy can be destructive for the ovary, whereas ablation may be incomplete, with a greater risk of recurrence. To the best of our knowledge, the modified combined technique seems to be more efficient in the treatment of endometriomas. (J Turk Ger Gynecol Assoc 2014; 15: 177-89) Key words: Endometrioma, laparoscopy, cystectomy, combined technique Received: 25 August, 2014 Accepted: 29 August, 2014 Ovarian cystectomy in endometriomas: Combined approach This article will be credited by TMA within the scope of CME/CPD.

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“…Remarkable declines in serum AMH were reported in patients with moderate to sever endometriosis, which was more pronounced in those with bilateral endometrioma. 25,[31][32][33][34][35][36] Ovaries with endometrioma may already have some damage with decreased ovarian reserve. [24][25][26] Lower anti-mullerian hormone serum levels and association with the severity of the disease found in women with endometriosis.…”

Section: Discussionmentioning

confidence: 99%

Endometrioma is a Responsible Factor for Reduced Ovarian Reserve

Begum

Ehsan²,

Ehsan³

et al. 2016

Bangladesh J Obstet Gynaecol

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Objective (s): The aim of the study was to assess ovarian reserve (OR) of patients with endometrioma and to explore the differences of ovarian reserve in age matched group of infertile patients without endometrioma.Materials and methods: This prospective analytic study was done in Infertility Care and Research Center, between January 2013 and December 2015 to assess the ovarian reserve of patients with endometrioma. During this period 105 patients of endometriosis with endometrioma were selected for study. Selection criteria were: no history of previous surgery, <36 years of age, no history of endocrine problems, no history of recent medical treatment for this condition within 6 months and no history of irregular menstruation. For ovarian reserve testing we assessed serum FSH, E2 and AMH. Patient of same age group who had no emdometrioma, no history of any surgery, no menstrual irregularity, endocrine disorder or any other medical diseases were taken as control to compare the ovarian reserve between these two groups. For control group also we did the same tests. Data was analyzed by SPSS package. One-way ANOVA test was done for test of significance. A p-value of <0.05 was considered as significant.Results: There was no difference in characteristics of patients of both groups regarding age, type of infertility and duration of infertility. Size of the endometriotic cysts were variable and average diameter of cyst was 6.2 ±2.32 cm. Most (58.10%) of the cysts were unilateral. There is a significant difference of FSH and AMH level between the groups. FSH of endometrioma and non-endometrioma group was 7.9 ±1.17 and 7.1 ±1.05 mIU/mL respectively with a p value of 0.029. Similar difference was present in AMH level, which was 2.42 ±.63 and 2.98 ±.88 ng/ mL in endometrioma and non-endometrioma group respectively with a p value of 0.020.Conclusion: This small study shows a reduced ovarian reserve in patients with endometrioma in comparison to patients of same parameters without endometrioma. It suggests that there is an association of presence of ovarian endometrioma and reduced ovarian reserveBangladesh J Obstet Gynaecol, 2015; Vol. 30(2) : 98-104

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Anti muellerian hormone serum levels in women with endometriosis: A case-control study

Cited by 23 publications

References 0 publications

A review of 15 years of ovarian tissue bank activities

A review of 15 years of ovarian tissue bank activities

Ovarian cystectomy in endometriomas: Combined approach

Endometrioma is a Responsible Factor for Reduced Ovarian Reserve

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