Anti-microbial potentials of hydrazonone derivatives: A promising scaffold

Structural modifications of coumarin derivatives: Determination of antioxidant and lipoxygenase (LOX) inhibitory activity

“…Hydrazone derivatives of carbonyl compounds are considered to be a biologically important class of compounds since they have been demonstrated to possess diverse biological and clinical applications. 28 Various substituted hydrazones are associated with a broad spectrum of biological activities such as antioxidant, antibacterial, antiviral, anti-HIV, analgesic, antiplatelet, antimicrobial, anticancer, anticonvulsant, anti-depressant, anti-inflammatory, anti-platelet, anti-malarial, anti-schistosomiasis, anthelmintic, anti-diabetic and trypanocidal. [29][30][31][32][33] Hydrazones possessing an azomethine -NHN@CH-group, are considered as derivatives of aldehydes and ketones in which the oxygen atom has been replaced by a NNHR functional group.…”

Synthesis and Anti-Inflammatory Activity of Hydrazide-Hydrazones Bearing Anacardic Acid and 1,2,3-Triazole Ring Based Hybrids

“…Hydrazone and acylhydrazone derivatives have been the subject of considerable interest in the development of novel compounds with antiinflammatory [2][3][4][5][6] , antidepressant 7 , analgesic 8 , anticonvulsant 9 , antimicrobial 10 , antifungal 11 , antitumor 12 , antioxidant 13 , antimalarial 14 , antiplatelet, and antiviral, antimycobacterial and vasodilator activities 15 .…”

(7-Chloroquinolin-4-yl)arylhydrazones: Candida albicansenzymatic repression and cytotoxicity evaluation, Part 2

“…These molecules are easily prepared and have diverse pharmacological potentials, which lead to the synthesis of various novel hydrazone compounds. Numerous studies have centered on hydrazones for the development of better biological molecules with low toxicity profiles 12,13 .…”

“…The biological potential of hydrazone derivatives has been widely described in the literature; considering the variety of biological activities described, the antimicrobial potential seems to be very significant [12][13][14] . Biological activity has been described against many strains.…”

“…In addition to the antimicrobial activity, hydrazones have also been reported to have anticancer, anti-inflammatory, antiprotozoal, antiplatelet and cardio-protective properties 14 . Many effective compounds, such as iproniazid and isocarboxazid, are synthesized by the reduction of hydrazide-hydrazones and are used in the treatment of tuberculosis (TB) and display an anti-depressant effect 12 .…”