Anti-microbial and therapeutic effects of modified Burow's solution on refractory otorrhea

Jinnouchi, Osamu; Kuwahara, Tomomi; Ishida, Shiro; Okano, Yoshiro; Kasei, Yasuko; Kunitomo, Kazufumi; Takeda, Noriaki

doi:10.1016/j.anl.2011.07.007

Cited by 13 publications

(7 citation statements)

References 16 publications

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“…Shimizu et al [19] have reported the successful treatment of a patient with malign externa otitis using Burow's solution. Jinnouchi et al [4] have reported the local treatment of 14 ears with persistent otorrhea using Burow's solution modified by fourfold dilution. However, other studies claim that Burow's solution has toxic effects on the inner ear [2,3,5] .…”

Section: Discussionmentioning

confidence: 99%

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The Effects of Topical Burow's and Castellani's Solutions on the Middle Ear Mucosa of Rats

Başal¹,

Günel²,

Eryılmaz³

et al. 2016

Int Adv Otol

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OBJECTIVE:The aim of this study is to investigate the early histopathologic effects of Burow's and Castellani's solutions on the middle ear mucosa of rats. MATERIALS and METHODS:The study was conducted with 26 Wistar albino female rats. Gelfoam that was soaked in 4% Burow's solution was inserted into the middle ears of the rats in the Burow group (n=10); over 2 weeks, 0.1 mL Burow's solution was administered once a day through perforation into the middle ear. The same procedure was applied to the rats in the Castellani group (n=10) using classical Castellani's solution and to the rats in the control group (n=6) using physiological saline solution. At day 1 after the last administration, all groups were decapitated; their bullas were dissected. The bullas were histopathologically evaluated and graded with respect to increase in leukocytes with polymorphic nuclei, mononuclear cell infiltration, and fibrosis. The data obtained were statistically analyzed. RESULTS:In the Burow group, the fibrosis scores were significantly higher than those in the control group (p=0.039), the scores of leukocytes with polymorphic nuclei were significantly higher than those in the control group (p=0.034), and the total scores were significantly higher than those in the control group (p=0.022). CONCLUSION:We suggest Castellani's solution as a safe alternative in the treatment of otomycosis and external otitis in the presence of tympanic membrane perforation. However, because of the inflammatory changes it causes in the middle ear mucosa, we do not recommend the use of Burow's solution in the presence of tympanic membrane perforation.

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Section: Discussionmentioning

confidence: 99%

“…The solution is a colorless and acidic mixture containing aluminum acetate and can be prepared at different densities [2] . In studies conducted using Burow's solution, 4%, 8%, and 13% concentrations are used frequently [3][4][5] . In our country, a ready-to-use preparation called Burow Galenik containing 4% aluminum acetate is available.…”

Section: Introductionmentioning

confidence: 99%

The Effects of Topical Burow's and Castellani's Solutions on the Middle Ear Mucosa of Rats

Başal¹,

Günel²,

Eryılmaz³

et al. 2016

Int Adv Otol

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“…If needed the antibiotic and/or antifungal agents may be based on the results of the culture and sensitivity reports. 16 Many patients respond well to meticulous microscopic aural toilet and topical antibiotic and steroid ear drops. The treatment is continued for at least two weeks.…”

Section: Discussionmentioning

confidence: 99%

Granular myringitis: current status of management

Bansal¹

2015

Int J Otorhinolaryngol Head Neck Surg

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<p class="abstract"><span lang="EN-US">The Granular Myringitis (GM) is not uncommon though in medical literature it has been reported among the rarer conditions. The aim of this article is to review the clinical features and management of Granular Myringitis (GM). GM is characterized by granulation tissue on the outer surface of the Tympanic Membrane (TM) with or without the involvement of deep bony External Auditory Canal (EAC). The granulations are either localized or diffuse. The granulations over tympanic membrane continue to grow slowly for years. The ensuing fibrosis in patients with granulations of deep bony meatal wall can result into an atresia of the deep bony EAC. The presenting symptom of GM is an ear discharge which may be foul-smelling. However many patients have a sensation of fullness, irritation, mild pain or itching in the ear. If perforation occurs the underlay perichondrium or temporalis fascia grafting is done. In some of the refractory cases granulations are removed and the raw area is covered with skin. Many patients respond well to meticulous microscopic aural toilet and topical antibiotic and steroid ear drops. If patients do not respond then application of topical caustic agents are employed.</span></p>

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“…An argument opposed the prescribing oral antibiotics for acute OE is the effectiveness of topical agents that do not contain antibiotics. Boric acid, acetic acid, and aluminum acetate are effective topical solutions as a single agent [21,22]. A randomized multicenter trial also found no significant differences in bacteriologic efficacy or pain duration between topical treatment and topical treatment combined with oral amoxicilin [20].…”

Section: Systemic Antimicrobialsmentioning

confidence: 99%