Anti-melanogenesis Constituents from the Seaweed Dictyota Coriacea

Abstract

This study was conducted to identify the anti-melanogenesis constituents from a seaweed Dictyota coriacea (Holmes). Three known compounds, viz. 1,9-dihydroxycrenulide (1), epiloliolide (2) and D-mannitol (3), were isolated from the ethanol extract. The melanin synthesis inhibition activities were evaluated using B16F10 melanoma cells for the isolates. Compared with the positive control, arbutin, compounds 1 and 2 exhibited more potency, showing 27.8 and 22.6 % inhibition activities at a substrate concentration of 30 μg/mL. Our studies also indicate that these compounds are not cytotoxic. Hence, they might prove to be useful therapeutic agents for treating hyperpigmentation and effective components of whitening cosmetics.

Anti-Hepatocellular Carcinoma (HepG2) Activities of Monoterpene Hydroxy Lactones Isolated from the Marine Microalga Tisochrysis Lutea

“…The chemical shifts and structural assignments (Table 1) were similar to those of loliolide (1) and epi-loliolide (2) (Figure 4) upon comparing with data previously reported in the literature on similar compounds synthesized chemically or found in brown algae [26][27][28][29]. These two carotenoid-derived metabolites are monoterpene lactones, also classified as norisoprenoids or apocarotenoids [28,30,31], which have often been isolated from various sources such as plants, algae, and other marine organisms [25,[32][33][34]. These types of metabolites are produced from the carotenoids fucoxanthin, zeaxanthin, and violaxanthin upon photo-oxidation or thermal degradation, among other catabolic pathways [33,34].…”

“…These types of metabolites are produced from the carotenoids fucoxanthin, zeaxanthin, and violaxanthin upon photo-oxidation or thermal degradation, among other catabolic pathways [33,34]. Carotenoids are well-known dietary supplements used as ingredients in food and cosmeceutical formulations (e.g., as colorants), and perform versatile roles in human health, including neuroprotection and the prevention and/or treatment of macular degeneration, inflammatory and rheumatoid arthritis, cataracts, cancer, These two carotenoid-derived metabolites are monoterpene lactones, also classified as norisoprenoids or apocarotenoids [28,30,31], which have often been isolated from various sources such as plants, algae, and other marine organisms [25,[32][33][34]. These types of metabolites are produced from the carotenoids fucoxanthin, zeaxanthin, and violaxanthin upon photo-oxidation or thermal degradation, among other catabolic pathways [33,34].…”

“…These two carotenoid-derived metabolites are monoterpene lactones, also classified as norisoprenoids or apocarotenoids [ 28 , 30 , 31 ], which have often been isolated from various sources such as plants, algae, and other marine organisms [ 25 , 32 , 33 , 34 ]. These types of metabolites are produced from the carotenoids fucoxanthin, zeaxanthin, and violaxanthin upon photo-oxidation or thermal degradation, among other catabolic pathways [ 33 , 34 ].…”

“…Loliolide was demonstrated to have antiapoptotic and antiscratching effects in human keratinocytes [ 43 ]. In addition, loliolide and isololiolide exhibited strong growth-inhibitory properties on cress and barnyard grass seedlings and anti-melanogenetic activity [ 30 , 32 , 44 ]. Therefore, the wide spectra of biological properties attributed to loliolide and its isomers [ 45 , 46 , 47 , 48 , 49 , 50 ] is a strong indication that further research is needed to fully understand the effects of these carotenoid catabolites on either animal, plant, or microbial cells.…”

Chemical Diversity and Biological Properties of Secondary Metabolites from Sea Hares of Aplysia Genus

“…Moreover, studies regarding the cytotoxicity of compound 136 showed moderate activity against human nasopharynx carcinoma (KB), human lung carcinoma (NSCLC-N6), murine leukemia (P-388), and murine leukemia expressing multi-drug-resistance gene (P-388/DOX) cells [ 162 ]. An anti-melanogenesis study demonstrated that 1,9-dihydroxycrenulide ( 137 ) inhibits melanin synthesis in B16F10 melanoma cells, pointing to a possible therapeutic use in the treatment of hyperpigmentation [ 163 ].…”