Anti-malarial herbal remedies of northeast India, Assam: An ethnobotanical survey

Namsa, Nima D.; Mandal, Manabendra; Tangjang, Sumpam

doi:10.1016/j.jep.2010.10.036

Cited by 33 publications

(15 citation statements)

References 36 publications

(22 reference statements)

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“…The juice of the leaves is applied to boils and pimples [ 17 ]. Many studies have evaluated the antimalarial activity of plant derivatives and indicated their efficacy against the Plasmodium species using in vivo and in vitro methods [ 2 , 8 – 10 , 14 , 15 , 18 , 19 ]. A recent study conducted in Thailand has suggested the promising activity of Plumbago indica Linn against both chloroquine resistant and chloroquine-sensitive strains of P. falciparum [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

“…Northeast region of India has great plant biodiversity potential and many plants are used in traditional medicine system for the treatment of various ailments [ 16 – 19 ]. Among the tribes of Assam, especially Bodo, Karbi, Mishing and Dimasa, the plant Aristolochia griffithii is used against insect and snake bite, skin problem, stomach problems and fever.…”

Section: Introductionmentioning

confidence: 99%

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Preliminary in vitro antiplasmodial activity of Aristolochia griffithii and Thalictrum foliolosum DC extracts against malaria parasite Plasmodium falciparum

et al. 2016

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BackgroundResistance development in human malaria parasites against commonly used antimalarial drugs has necessitated the scientific exploration of traditionally used antimalarial plants. Plant derivatives have been used for curing malaria historically. The present study involves in vitro evaluation of two medicinally important plants Aristolochia griffithii and Thalictrum foliolosum DC used in antimalarial chemotherapy by the tribes of northeast India.MethodChloroform, ethyl acetate and n–butanol extracts of Aristolochia griffithii and Thalictrum foliolosum DC were evaluated in vitro against chloroquine sensitive (SS) and chloroquine resistance strains (RS) of P. falciparum. The tests were conducted following WHO standard method and the inhibition of parasite (IC50) was calculated.ResultsIn A. griffithii, the IC50 value for ethyl acetate extracts against SS was 6.2 ± 0.02 μg/ml and found to be lower than chloroform extracts, which exhibited an IC50 value of 14.1 ± 0.1 μg/ml (t = 191.1; p < 0.0001). The IC50 values of both chloroform and ethyl acetate extracts for RS were higher as compared to the SS (p < 0.0001). In T. foliolosum DC the IC50 concentration of chloroform extracts for SS and RS were 0.5 ± 0.0 and 1.1 ± 0.0 μg/ml respectively (t = 54.2; p < 0.0001).ConclusionThe present findings, although preliminary, but scientifically demonstrate that identification and isolation of active compounds of these two plant materials and testing against different Plasmodium species could lead to the development of potential antimalarial drugs for future.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Preliminary in vitro antiplasmodial activity of Aristolochia griffithii and Thalictrum foliolosum DC extracts against malaria parasite Plasmodium falciparum

et al. 2016

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“…Earlier, tribal people used to approach their traditional Oja (medicine man) or Gonok (event teller) for their treatment as they were the only accessible and approachable healers for them. For treating malaria the local communities of the district used some medicinal plants available in the forests in their vicinity as other local communities of Assam used to do [19]. But now ASHA is more easily approachable to them for their health issues and since medicines for preliminary treatment of different diseases are available to them through ASHA, the tribal villagers have started to choose modern medicines as a reliable option for their treatment.…”

Section: Discussionmentioning

confidence: 99%

Malaria Prevalence in Forest and Nonforest Areas of Kokrajhar District of Assam

Nath

Mwchahary

2012

ISRN Public Health

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An analysis of malaria prevalence and its trends in Kokrajhar district of Assam over the last ten years starting from 2001 to 2010 shows that the occurrence of malaria in the forest area is significantly higher than in the nonforest area (). The transmission of malaria parasite takes place through only two Plasmodium species ofP. falciparum(PF) andP. vivax(PV) in both the forest and nonforest areas of the district, and the prevalence ofP. falciparumhas been found higher. The annual blood examination rate (ABER) is relatively lower in forest area than the nonforest area while annual parasite incidence (API) of the former was much higher. Nearly one-third of the population of the district is under high risk of being affected. The malaria API and forest cover of the district during the period are negatively correlated with a coefficient of −0.57. Special measures are necessary to contain the transmission of malaria in forest area.

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“…Numerous ethnobotanical surveys on traditional antimalarial plants have been conducted to preserve traditional knowledge and to identify the people's usage customs. The most relevant studies are listed in the Table 1 ( Leaman et al 1995, Marshall et al 2000, Randrianarivelojosia et al 2003, Bidla et al 2004, Asase et al 2005, Njoroge and Bussmann 2006, Ouattara et al 2006, Alshawsh et al 2007, Botsaris 2007, Odugbemi et al 2007, Roumy et al 2007, Tene et al 2007, Adekunle 2008, Ajibesin et al 2008, Hlaing et al 2008, Ramalhete et al 2008, Kantamreddi et al 2009, AlAdhroey et al 2010, Jain and Singh 2010, Karou et al 2011, Nadembega et al 2011, Namsa et al 2011, Karunamoorthi and Tsehaye 2012.…”

Section: Ethnobotanical Studies On Traditional Antimalarial Plantsmentioning

confidence: 99%

Role of Traditional Antimalarial Plants in the Battle Against the Global Malaria Burden

Karunamoorthi

Sabesan

Jegajeevanram³

et al. 2013

Vector-Borne and Zoonotic Diseases

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Malaria continues to be a major global public health problem with 3.3 billion people at risk in 106 endemic countries. Globally, over 1000 plants have been used as potential antimalarials in resource-poor settings due to fragile health-care systems and lack of accessibility and affordability of artemisinin-based combination therapies (ACTs). Although many believe that the use of medicinal plants that have folklore reputations for antimalarial properties is relatively safe, many herbs may be potentially toxic due to their intrinsic adverse side effects. Therefore, herbal-derived remedies require powerful and deep assessment of their pharmacological qualities to establish their mode of action, safety, quality, and efficacy. In addition, the evolution of drug resistance also demands new antimalarial agents. This can be achieved by forming a vibrant antimalarial discovery pipeline among all stakeholders, including traditional healers, ethnobotanists, scientists, entomologists, pharmacists, and research institutions, for the isolation and characterization of the bioactive compounds with the ultimate objective of finding novel modes of action antimalarial compounds that can be used to fight against drug-resistant malarial parasites.

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Anti-malarial herbal remedies of northeast India, Assam: An ethnobotanical survey

Cited by 33 publications

References 36 publications

Preliminary in vitro antiplasmodial activity of Aristolochia griffithii and Thalictrum foliolosum DC extracts against malaria parasite Plasmodium falciparum

Preliminary in vitro antiplasmodial activity of Aristolochia griffithii and Thalictrum foliolosum DC extracts against malaria parasite Plasmodium falciparum

Malaria Prevalence in Forest and Nonforest Areas of Kokrajhar District of Assam

Role of Traditional Antimalarial Plants in the Battle Against the Global Malaria Burden

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