Anti-lymphocyte serum: A review of its immunological effects and therapeutic value

Rolland, Jennifer M.; Nairn, R. C.

doi:10.3109/00313027209068928

Cited by 6 publications

(2 citation statements)

References 293 publications

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“…Earlier inconsistent results hindered the use of ALS due to standardization and purity concerns. This improved in the 1930s, where more consistent lymphopenia was produced 123 . In the 1950s, suppression of the delayed hypersensitivity reaction to tuberculoprotein, dinitrochlorobenzene and diphtheria toxin was shown in ALS‐treated guinea pigs.…”

Section: Therapymentioning

confidence: 98%

“…This improved in the 1930s, where more consistent lymphopenia was produced. 123 In the 1950s, suppression of the delayed hypersensitivity reaction to tuberculoprotein, dinitrochlorobenzene and diphtheria toxin was shown in ALS-treated guinea pigs. In the early 1960s, significant prolongation of skin allograft survival in ALS-treated rats was observed between histoincompatible donor and recipient; 124,125 a few years later, kidney-transplanted dogs increased their survival following ALS administration.…”

Section: Immunosuppressive Therapymentioning

confidence: 99%

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Acquired severe aplastic anaemia: how medical therapy evolved in the 20th and 21st centuries

Scheinberg

2021

Br J Haematol

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The progress in aplastic anaemia (AA) management is one of success. Once an obscure entity resulting in death in most affected can now be successfully treated with either haematopoietic stem cell transplantation (HSCT) or immunosuppressive therapy (IST). The mechanisms that underly the diminution of haematopoietic stem cells (HSCs) are now better elucidated, and include genetics and immunological alterations. Advances in supportive care with better antimicrobials, safer blood products and iron chelation have greatly impacted AA outcomes. Working somewhat 'mysteriously', anti-thymocyte globulin (ATG) forms the base for both HSCT and IST protocols. Efforts to augment immunosuppression potency have not, unfortunately, led to better outcomes. Stimulating HSCs, an often-sought approach, has not been effective historically. The thrombopoietin receptor agonists (Tpo-RA) have been effective in stimulating early HSCs in AA despite the high endogenous Tpo levels. Dosing, timing and best combinations with Tpo-RAs are being defined to improve HSCs expansion in AA with minimal added toxicity. The more comprehensive access and advances in HSCT and IST protocols are likely to benefit AA patients worldwide. The focus of this review will be on the medical treatment advances in AA.

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Section: Therapymentioning

confidence: 98%

Section: Immunosuppressive Therapymentioning

confidence: 99%

Acquired severe aplastic anaemia: how medical therapy evolved in the 20th and 21st centuries

Scheinberg

2021

Br J Haematol

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The effect of immunosuppressive agents on lymphocyte subsets in rat peripheral blood

Thompson

Bowen

Burton

1987

International Journal of Immunopharmacology

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Effect of anti‐thymocyte serum on development of gingivitis in dogs

Nobréus

Attström

Egelberg

1974

J of Periodontal Research

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The effect of repeated injections of heterologous anti‐thymocyte globulin (ATS) on the development of gingivitis has been studied in beagle dogs. Control dogs were injected with control rabbit immunoglobulin. The immunosuppressive effect of the antiserum was evaluated from the inhibition of a delayed hypersensitivity reaction in the skin towards l‐dinitro‐2.4‐chlorobenzene (DNCB). The gingival condition was determined by measurements of crevicular leukocytes, gingival fluid, acid phosphatase activity in crevicular samples and by counts of inflammatory cells in sections of gingival biopsies. Antiserum administration, but not control rabbit IgG, abolished the hypersensitivity reaction in the skin towards DNCB. The parameters of gingival inflammation increased during the 28day experimental period, both in the experimental and in the control dogs. The results indicate that cellular immunity does not play a major role for the development of gingival inflammation in beagle dogs.

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Anti-lymphocyte serum: A review of its immunological effects and therapeutic value

Cited by 6 publications

References 293 publications

Acquired severe aplastic anaemia: how medical therapy evolved in the 20th and 21st centuries

Acquired severe aplastic anaemia: how medical therapy evolved in the 20th and 21st centuries

The effect of immunosuppressive agents on lymphocyte subsets in rat peripheral blood

Effect of anti‐thymocyte serum on development of gingivitis in dogs

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