Anti-Lung-Cancer Activity and Liposome-Based Delivery Systems of<i>β</i>-Elemene

Chen, Mei Wan; Zhang, Jin Ming; Yu, Si Qin; Wang, Sheng Peng; Zhang, Zai Jun; Chen, Jian Qiang; Xiao, Jian; Wang, Yi Tao

doi:10.1155/2012/259523

Cited by 16 publications

(12 citation statements)

References 31 publications

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“…Increased collagen and reduced collagen breakdown in the wound is an important factor in wound granulation and scar formation and is present in airway stenosis. Currently, the traditional Chinese medicine β-elemene is widely used in the complementary treatment of different types of malignancies [20,21,22,23,24,25,26,27]. β-Elemene has also been found to inhibit the expression of angiotensin II and RhoA/ROCK signaling in hepatic stellate cells and to delay the progression of hepatic fibrosis [28,29,30,31,32].…”

Section: Discussionmentioning

confidence: 99%

“…β-Elemene, a compound derived from Zingiberaceae Curcuma wenyujin rhizome [20,21,22,23] used in traditional Chinese medicine, has shown anticancer effects against a broad spectrum of tumors. Its main biological activities were to reduce the ability of tumor cell mitosis, induce apoptosis of tumor cells, and inhibit the growth of tumor cells.…”

Section: Introductionmentioning

confidence: 99%

“…As a promising anticancer drug, it has played an important role in enhancing the effects of many anticancer drugs and has been widely used in the treatment of different kinds of malignancies and in reducing the side effects of chemotherapy. It has also been shown to reverse multidrug resistance [20,21,22,23,24,25,26,27]. In addition, research has shown that β-elemene can inhibit proliferation of human bone fibroblasts and lens epithelial cells and that it can inhibit liver fibrosis [28,29,30,31,32,33,34].…”

Section: Introductionmentioning

confidence: 99%

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Inhibitory Effect of β-Elemene on Human Airway Granulation Tissue in vivo and in vitro

Li¹,

Zeng

Yang

2016

Respiration

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Background: Recurrent airway granulation hyperplasia and scar formation make airway stenosis a clinical challenge. Therefore, a new approach for the treatment of airway stenosis is necessary. Objective: To explore the inhibitory effect of β-elemene on the proliferation of fibroblasts and airway granulation. Methods: In vivo: (1) study of the effect of local β-elemene injection by bronchoscopy. (2) During bronchoscopy, granulation tissues both before and after treatment were obtained. HE staining was performed and the result compared. In vitro: (1) human airway primary fibroblasts were purified and characterized. (2) Fibroblasts were treated with β-elemene and normal saline (NS) and then examined by optical and electron microscopy. (3) Fibroblasts treated with β-elemene or NS were assessed for viability by tetrazolium salt assay. (4) Apoptotic rates were determined by flow cytometry. Results: In vivo: (1) after local injection of β- elemene, airway granulation tissue was reduced. (2) Granulation tissue was found to have less edema, and fibroblasts turned into mature fiber cells. In vitro: (1) human airway primary fibroblasts were successfully purified and cultured. (2) Compared with the control group, fibroblasts of the experimental group became clumped, the plasma granules were increased, and some fibroblasts lost their nucleus and organelles. (3) Compared with the control group, reduction of cell viability was detected with increased concentrations of β-elemene. (4) With increased concentrations of β-elemene, apoptotic rates of the fibroblasts were raised compared with the control group. Conclusions: β-Elemene may induce apoptosis and necrosis of airway primary fibroblasts and inhibit the proliferation of fibroblasts and airway granulation. The results provide a new approach for the treatment of airway stenosis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Inhibitory Effect of β-Elemene on Human Airway Granulation Tissue in vivo and in vitro

Li¹,

Zeng

Yang

2016

Respiration

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“…As a potential anticancer drug, β-elemene has broad application prospects associated with 3 key advantages: it can be sourced from more than 50 different herbs and plants; its potent anticancer effects include inhibiting angiogenesis, inducing tumour-cell apoptosis, enhancing radiation sensitivity, and improving chemotherapeutic effects in combination with other anticancer drugs. Furthermore, it exerts only slight side effects, with mild liver and kidney function damage and no bone marrow suppression 21 .…”

Section: Discussionmentioning

confidence: 99%

Comparative Efficacy of Whole-Brain Radiotherapy with and without Elemene Liposomes in Patients with Multiple Brain Metastases from Non-Small-Cell Lung Carcinoma

et al. 2016

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Purpose We explored and compared the clinical effects of whole-brain radiotherapy (wbrt) with and without elemene liposomes in patients with multiple brain metastases from non-small-cell lung carcinoma (nsclc). MethodsWe retrospectively analyzed 62 patients with multiple brain metastases from nsclc who received wbrt (30 Gy in 10 fractions) at Shengjing Hospital of China Medical University from January 2012 to May 2013. In 30 patients, elemene liposomes (400 mg) were injected intravenously via a peripherally inserted central catheter for 21 consecutive days from the first day of radiotherapy. Overall survival (os) and nervous system progression-free survival (npfs) for the two groups were compared by Kaplan-Meier analysis. Factors influencing npfs were examined by Cox regression analysis. Chi-square or Fisher exact tests were used for group comparisons. ResultsThe median os was 9.0 months in the wbrt plus elemene group and 7.8 months in the wbrt-alone group (p = 0.581); the equivalent median npfs durations were 5.2 months and 3.7 months (p = 0.005). Patient treatment plan was an independent factor associated with npfs (p = 0.002). Tumour response and disease-control rates in the wbrt plus elemene group were 26.67% and 76.67% respectively; they were 18.75% and 62.5% in the wbrt group (p = 0.452). Compared with the patients in the wbrt-alone group, significantly fewer patients in the wbrt plus elemene group developed headaches (p = 0.04); quality of life was also significantly higher in the wbrt plus elemene group both at 1 month and at 2 months (p = 0.021 and p = 0.001 respectively). ConclusionsThe addition of elemene liposomes to wbrt might prolong npfs in patients with multiple brain metastases from nsclc, while also reducing the incidence of headache and improving patient quality of life.

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“…Phase II clinical trials with β -elemene are in development, and aiming to improve of its pharmacokinetics new delivery systems are being produced, including liposome-based delivery systems of β -elemene. The authors emphasize that β -elemene liposomes will be critical for future clinical applications of β -elemene in lung cancer treatment [66]. Herbal extracts have also been studied using new technologies.…”

Section: Introductionmentioning

confidence: 99%

Medicinal Plants and Other Living Organisms with Antitumor Potential against Lung Cancer

Monteiro

Bastos

Barbosa-Filho

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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Lung cancer is a disease with high morbidity and mortality rates. As a result, it is often associated with a significant amount of suffering and a general decrease in the quality of life. Herbal medicines are recognized as an attractive approach to lung cancer therapy with little side effects and are a major source of new drugs. The aim of this work was to review the medicinal plants and other living organisms with antitumor potential against lung cancer. The assays were conducted with animals and humans, and Lewis lung carcinoma was the most used experimental model. China, Japan, South Korea, and Ethiopia were the countries that most published studies of species with antitumor activity. Of the 38 plants evaluated, 27 demonstrated antitumor activity. In addition, six other living organisms were cited for antitumor activity against lung cancer. Mechanisms of action, combination with chemotherapeutic drugs, and new technologies to increase activity and reduce the toxicity of the treatment are discussed. This review was based on the NAPRALERT databank, Web of Science, and Chemical Abstracts. This work shows that natural products from plants continue to be a rich source of herbal medicines or biologically active compounds against cancer.

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Anti-Lung-Cancer Activity and Liposome-Based Delivery Systems ofβ-Elemene

Cited by 16 publications

References 31 publications

Inhibitory Effect of β-Elemene on Human Airway Granulation Tissue in vivo and in vitro

Inhibitory Effect of β-Elemene on Human Airway Granulation Tissue in vivo and in vitro

Comparative Efficacy of Whole-Brain Radiotherapy with and without Elemene Liposomes in Patients with Multiple Brain Metastases from Non-Small-Cell Lung Carcinoma

Medicinal Plants and Other Living Organisms with Antitumor Potential against Lung Cancer

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