Anti-liver cancer constituents from the thorns of Gleditsia sinensis

Yu, Jinqian; Xian, Yun-Xia; Geng, Yun; Zhou, Honglei; Wang, Xiao

doi:10.1016/j.phytol.2015.07.018

Cited by 15 publications

(3 citation statements)

References 11 publications

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“…The other methoxy group (δ H 3.66; δ C 51.6) corresponds to a methyl ester deduced from its upfield shifted (δ C 51.6) signal [ 12 ] and from its HMBC correlation with the ester carbonyl (δ C 174.5). Comparison of these spectroscopic data with the literature revealed that the compound was very similar to ω-feruloyloxyacid [ 27 ] and ethyl 24-(feruloyloxy)docosanoate [ 28 ]. The only difference was the absence of a methoxy group and the length of the aliphatic chain.…”

Section: Resultsmentioning

confidence: 88%

Cytotoxic Compounds from Aloe megalacantha

et al. 2017

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Phytochemical investigation of the ethyl acetate extract of the roots of Aloe megalacantha led to the isolation of four new natural products—1,8-dimethoxynepodinol (1), aloesaponarin III (2), 10-O-methylchrysalodin (3) and methyl-26-O-feruloyl-oxyhexacosanate (4)—along with ten known compounds. All purified metabolites were characterized by NMR, mass spectrometric analyses and comparison with literature data. The isolates were evaluated for their cytotoxic activity against a human cervix carcinoma cell line KB-3-1 and some of them exhibited good activity, with aloesaponarin II (IC50 = 0.98 µM) being the most active compound.

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Section: Resultsmentioning

confidence: 88%

Cytotoxic Compounds from Aloe megalacantha

et al. 2017

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“…Except the extracts, three individual compounds identified from Spina Gleditsiae have been reported to present cytotoxic effects to human SK-Hep-1 liver cancer cells in vitro . Among them, p-hydroxyl cinnamic aldehyde exhibited cytotoxicity with IC 50 at a value as low as 38.18 µ M, while trans-coniferyl aldehyde and sinapaldehyde showed moderate effects with IC 50 values of 58.11 and 54.61 µ M, respectively [ 19 ].…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

From Traditional Usage to Pharmacological Evidence: A Systematic Mini‐Review of Spina Gleditsiae

Gao

Yang

Yin

2016

Evidence-Based Complementary and Alternative Medicine

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Spina Gleditsiae is an important herb with various medicinal properties in traditional and folk medicinal systems of East Asian countries. In China through the centuries, it has been traditionally used as a source of drugs for anticancer, detoxication, detumescence, apocenosis, and antiparasites effects. Recently, an increasing number of studies have been reported regarding its chemical constituents and pharmacological activities. To further evidence the traditional use, phytochemicals, and pharmacological mechanisms of this herb, a systematic literature review was performed herein for Spina Gleditsiae. The review approach consisted of searching several web-based scientific databases including PubMed, Web of Science, and Elsevier using the keywords “Spina Gleditsiae”, “Zao Jiao Ci”, and “Gleditsia sinensis”. Based on the proposed criteria, 17 articles were evaluated in detail. According to the reviewed data, it is quite evident that Spina Gleditsiae contains a number of bioactive phytochemical components, which account for variety medicinal values including anticancer, anti-inflammatory, antiatherogenic, antimicrobial, antiallergic, and antivirus activities. The phytochemical and pharmacological studies reviewed herein strongly underpin a fundamental understanding of herbal Spina Gleditsiae and support its ongoing clinical uses in China. The further phytochemical evaluation, safety verification, and clinical trials are expected to progress Spina Gleditsiae-based development to finally transform the traditional TCM herb Spina Gleditsiae to the valuable authorized drug.

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“…Additionally, the cooked and candied endosperm of seeds can be consumed directly. Moreover, the dried thorns of G. sinensis contain a diverse array of potent medicinal compounds and exert inhibitory effects on the proliferation of colon cancer cells, liver cancer cells, gastric cancer cells, and smooth muscle cells ( Lee et al, 2010 ; Yu et al, 2015 ; Lee et al, 2013 ; Lee et al, 2012 ). Consequently, its thorns have gained widespread usage as an herbal medicine in various Asian countries.…”

Section: Introductionmentioning

confidence: 99%

Waterlogging in soil restricts the growth of Gleditsia sinensis seedlings and inhibits the accumulation of lignans and phenolic acids in thorns

Luo,

Shi,

Wang

et al. 2024

PeerJ

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Gleditsia sinensis, commonly known as Chinese Zaojiao, has important economic value and medicinal compounds in its fruits and thorns, making it widely cultivated artificially in China. However, the available literature on the impact of waterlogging on the growth of G. sinensis seedlings and the accumulation of metabolite compounds in its thorns is limited. To address this knowledge gap, G. sinensis seedlings were planted in soil supplemented with pindstrup substrate, which enhances the water-holding capacity of the soil. The analyses of morphological traits and nutrient elements in one-year-old G. sinensis seedlings grown naturally under ambient conditions and metabolite accumulation in its thorns were conducted. The results showed that the waterlogged soil significantly diminished the height, fresh weight, and dry weight of seedling roots and stems (P < 0.05). Furthermore, waterlogging hindered the uptake of iron (Fe) and manganese (Mn), as well as the transport of potassium (K). The identified metabolites within the thorns were categorized into 16 distinct groups. Relative to the control soil, fatty acids and derivatives were the most down-regulated metabolites in the waterlogged soil, accounting for 40.58% of the total metabolites, followed by lignans (38.71%), phenolic acids (34.48%), saccharides and alcohols (34.15%), steroids (16.67%), alkaloids (12.24%), flavonoids (9.28%), and glycerophospholipids (7.41%). Conversely, nucleotides and derivatives experienced the greatest up-regulation in the waterlogged soil, accounting for 50.00% of the total metabolites. In conclusion, waterlogging negatively impacted the growth of G. sinensis seedlings and inhibited the accumulation of metabolites. Hence, when considering the accumulation of secondary metabolites such as lignans and phenolic acids, appropriate management of soil moisture levels should be taken into account.

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Anti-liver cancer constituents from the thorns of Gleditsia sinensis

Cited by 15 publications

References 11 publications

Cytotoxic Compounds from Aloe megalacantha

Cytotoxic Compounds from Aloe megalacantha

From Traditional Usage to Pharmacological Evidence: A Systematic Mini‐Review of Spina Gleditsiae

Waterlogging in soil restricts the growth of Gleditsia sinensis seedlings and inhibits the accumulation of lignans and phenolic acids in thorns

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