Anti-Leishmanial activity of homo- and heteroleptic bismuth(III) carboxylates

Andrews, Philip C.; Frank, René; Junk, Peter Courtney; Kędzierski, Łukasz; Kumar, Ish; MacLellan, Jonathan G.

doi:10.1016/j.jinorgbio.2010.08.007

Cited by 53 publications

(40 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The antimicrobial potency could be increased by mixing bismuth(III) complexes containing pyrazoline and salicylate or acetate moieties as well [75]. Recently, Andrews and co-workers tested their library of tris-carboxylate bismuth(III) complexes derived from common NSAIDs against the parasite Leishmania major promastigotes [24]. The NSAID free acids and their bismuth derivatives show negligible antileishmanial activity at concentrations 1.95-250 μg mL −1 against the promastigotes of L. major.…”

Section: Therapeutic Effect On Gastrointestinal Diseasementioning

confidence: 99%

“…The NSAID free acids and their bismuth derivatives show negligible antileishmanial activity at concentrations 1.95-250 μg mL −1 against the promastigotes of L. major. Meanwhile, several bis-carboxylate phenylbismuth(III) and tris-carboxylate bismuth(III) complexes were synthesized from the corresponding substituted benzoic acid derivatives [24], showing significant antiLeishmanial activity against the promastigotes of L. major V121 at very low concentrations, while their respective free carboxylic acids display no activity. These bismuth(III) complexes also inhibited the growth of the human fibroblast cells at all concentrations studied (1.95-500 μg mL −1 ).…”

Section: Therapeutic Effect On Gastrointestinal Diseasementioning

confidence: 99%

“…Bi(III) alone is not responsible for high toxicity, which has been evidenced by the low toxicity of both BiCl 3 and Bi(NO 3 ) 3 against human fibroblast cells. Thus, the overall toxicity of bismuth(III) complexes toward the parasite and mammalian Bismuth complexes 391 cells is dependent on both ligand and metal [24]. Although the antimicrobial activities of bismuth compounds and their nanoparticles have been reported (table 2), the micro-organism inhibition of bismuth-based MOFs was rarely involved.…”

Section: Therapeutic Effect On Gastrointestinal Diseasementioning

confidence: 99%

See 2 more Smart Citations

Review: Bismuth complexes: synthesis and applications in biomedicine

Yang

Ouyang

et al. 2015

Journal of Coordination Chemistry

120

View full text Add to dashboard Cite

This paper reviews the synthesis and biomedical applications of bismuth complexes with unusually low toxicity and excellent clinical performances, summarizes their main synthesis methods, and biomedical applications as drugs for the therapeutic treatment of gastrointestinal disease, Helicobacter pylori infection, and various cancers; especially, describes the development of bismuth-based MOFs in the drug delivery and potential application in cancer treatment. *Corresponding authors.A variety of bismuth complexes have been extensively explored in biomedical applications. The well-known low toxicity and environmental friendliness of bismuth salts make them valuable for large-scale synthesis of various bismuth-based complexes, which become more significant as active pharmaceutical ingredients of medical products. Bismuth complexes have been widely and preferably used in biomedicine with satisfactory therapeutic effect, which is highlighted in this review. However, their synthesis methods have been scarcely summarized. The classification of the main synthesis methods of bismuth complexes has been done here, followed by updates of the relevant advances concerning applications in biomedicine such as therapeutic effect on gastrointestinal diseases, antimicrobial, and anticancer activities, and the description of the side effect and biotoxicity resulting from long-term use of bismuth as well. Bismuth containing metal-organic frameworks, newly developed bismuth-based materials, are also discussed here, becoming a hot research topic recently. An outlook for future study on the potential use of bismuth complexes in biomedicine is provided in the end.

show abstract

Section: Therapeutic Effect On Gastrointestinal Diseasementioning

confidence: 99%

Section: Therapeutic Effect On Gastrointestinal Diseasementioning

confidence: 99%

Section: Therapeutic Effect On Gastrointestinal Diseasementioning

confidence: 99%

See 1 more Smart Citation

Review: Bismuth complexes: synthesis and applications in biomedicine

Yang

Ouyang

et al. 2015

Journal of Coordination Chemistry

120

View full text Add to dashboard Cite

show abstract

“…Despite the close periodic table relationship of antimony and bismuth, there are only a few reports in the literature of bismuthbased drugs being developed and evaluated as anti-leishmanial agents [49]. On the other hand, new bismuth complexes with DNA affinity and activity against cancer cell were reported [50].…”

Section: Bi Complexesmentioning

confidence: 99%

“…In this regard, a series of bismuth III complexes of Non Steroidal Anti Inflammatory Drugs (NSAIDS) and benzoic acids were synthesized and tested against the parasite L. major promastigotes and assessed for their toxicity to mammalian cells (human fibroblast cells) [49]. The bismuth III complexes of substituted benzoic acids show significant anti-leishmanial activity against the promastigotes of L. major at very low concentrations and the most active compounds was [PhBi(o-MeOC 6 H 4 CO 2 ) 2 (bipy)], 28 with IC 50 of 1.9 mg/mL that in its crystal structure, Bi showed hexacoordinate with a distorted pentagonal pyramidal geometry.…”

Section: Bi Complexesmentioning

confidence: 99%

Importance of metal complexes for development of potential leishmanicidal agents

Tahghighi

2014

Journal of Organometallic Chemistry

View full text Add to dashboard Cite

Bismuth: Inorganic Chemistry

Whitmire

2004

Encyclopedia of Inorganic and Bioinorganic Chemistry

View full text Add to dashboard Cite

This review presents findings from 420 references. Bismuth has a diverse chemistry from the properties of the element to those of its important solid‐state compounds and its varied coordination complexes. Bismuth is the heaviest stable element whose chemistry is dominated by the +3 oxidation state, but −3, +1, +2, and +5 oxidation numbers are also accessible. In contrast to the lighter pnictogens, very few inorganic bismuth(V) compounds have been reported. The best characterized of these is BiF 5 , which is a strongly oxidizing Lewis acid that readily forms the BiF 6 − ion in the presence of a variety of F− ion donors. In this review, the chemistry of bismuth is organized by compound classification. Included are sections on the properties of the element, its intermetallic compounds and important solid‐state materials such as the bismuth oxides, chalcogenides, and pnictides. Recent work has been directed toward production of elemental bismuth and key solid‐state compounds in nanoparticle form. The solid‐state materials have important applications including high TC superconductors, ferroelectric, and piezoelectric materials, oxide ion conductors, catalysts, thermoelectric materials, etc. In its reduced compounds with alkali and alkaline earth metals, bismuth forms a number of homometallic and heterometallic anionic Zintl ions showing Bi–Bi bonding and a strong tendency toward cluster formation. Cationic clusters in reduced halide species have been observed. Bi–Bi single and double bonds are known. Molecular compounds are discussed and organized by the donor elements coordinated to bismuth, including sections on amines and amides, alkoxides, carboxylates, thiolates, and halides. The halides along with Bi(NO 3 ) 3 · 5H2O are amongst the most common starting materials for synthesizing other bismuth complexes. The alkoxide and carboxylate complexes are subject to facile hydrolysis leading to a wide variety of oxo‐alkoxide and oxo‐carboxylate complexes. Particularly stable configurations for these oxo clusters are Bi 9 and Bi 38 . These latter two cluster sizes stabilized by salicylate ligands are good model compounds for the bismuth subcarboxylate compounds, which have found widespread medicinal usage. High coordination numbers ranging from two to nine are common and the Bi 3+ ion is well‐known for its high Lewis acidity. Despite its identity as a heavy metal, its compounds are generally nontoxic to humans and enjoy a wide application as antibacterial and antifungal agents. Aspects of the biological chemistry of bismuth compounds are surveyed. A rich chemistry of bismuth coordinated to organometallic transition metal fragments is well developed. Many Fe, Co, Ru, Os, and Re metal carbonyl complexes have been reported as well as cyclopentadienyl metal derivatives. Unusual structure and bonding patterns have been observed in these compounds that include representatives from Groups 6 through 11 as well as one organometallic lanthanide complex.

show abstract

Anti-Leishmanial activity of homo- and heteroleptic bismuth(III) carboxylates

Cited by 53 publications

References 22 publications

Review: Bismuth complexes: synthesis and applications in biomedicine

Review: Bismuth complexes: synthesis and applications in biomedicine

Importance of metal complexes for development of potential leishmanicidal agents

Bismuth: Inorganic Chemistry

Contact Info

Product

Resources

About