Anti-influenza (H1N1) potential of leaf and stem bark extracts of selected medicinal plants of South India

Enkhtaivan, Gansukh; John, K.M. Maria; Ayyanar, Muniappan; Sekar, T.; Jin, Kijoun; Kim, Doo Hwan

doi:10.1016/j.sjbs.2015.01.011

Cited by 29 publications

(14 citation statements)

References 20 publications

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“…In 2015, Enkhtaivan et al [61] performed a comprehensive study on the total content of polyphenols in the bark of the following species Cayratia pedata (Lam.) Gagnep, Vitaceae, Chloroxylon swietenia DC., Rutaceae, Diotacanthus albiflorus Benth., Acanthaceae, Strychnos minor Dennst., Loganiaceae and Strychnos nux-vomica Dop., Loganiaceae.…”

Section: Methods Used To Extract Phenolic Compounds From the Bark mentioning

confidence: 99%

A Critical Review of Phenolic Compounds Extracted from the Bark of Woody Vascular Plants and Their Potential Biological Activity

2019

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Polyphenols are one of the largest and most widespread groups of secondary metabolites in the plants world. These compounds are of particular interest due to their occurrence and the properties they possess. The main sources of phenolic compounds are fruits and vegetables, but lately, more and more studies refer to woody vascular plants, especially to bark, as an important source of phenolic compounds with a potential biological effect. This study aims to bring together information on the phenolic compounds present in the bark of woody vascular plants by discussing extraction methods, the chemical composition of the extracts and potential biological effects. The literature data used in this paper were collected via PubMed (2004–2019). Search terms were: bark, rhytidome, woody vascular plant, polyphenols, phenolic compounds, biologic activity, antioxidant, immunostimulatory, antimutagenic, antibacterial, anti-inflammatory, and antitumoral. This paper intends to highlight the fact that the polyphenolic extracts obtained from the bark of woody vascular plants represent sources of bioactive compounds with antioxidant, immunostimulatory, antimutagenic, antibacterial properties, etc. Future research directions should be directed towards identification and isolation of bioactive compounds. Consequently, biologically active compounds obtained from the bark of woody plants could be exploited on an industrial scale.

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Section: Methods Used To Extract Phenolic Compounds From the Bark mentioning

confidence: 99%

A Critical Review of Phenolic Compounds Extracted from the Bark of Woody Vascular Plants and Their Potential Biological Activity

2019

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“…This compound attenuates the translation rate of viral proteins or decreases the stability of viral protein [25]. Moreover, gallic acid was reported to inhibit several other viruses such as influenza virus, foodborne viral surrogates, murine norovirus-1, and feline calicivirus-F9 [26,27]. The antiviral activities of gallic acid might be caused by the hydrophobic interaction between the functional group (hydroxyl) and virion components, bind to free radicals and exert an antioxidant effect [25].…”

Section: Resultsmentioning

confidence: 99%

Antihepatitis C Virus Activity of Indonesian Mahogany (Toona Sureni)

Hafid

Wahyuni

Tumewu

et al. 2018

Asian J Pharm Clin Res

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Objective: Toona sureni (Indonesian mahogany) is a member of Meliaceae family and locally known as suren. Previous study reported that T. sureni leaves extract exhibited antiviral activity with 50% inhibitory concentration (IC 50 ) value of 13.9 ± 1.6 µg/ml against hepatitis C virus (HCV) J6/JFH1. Cytotoxicity analysis of T. sureni leaves extract did not reveal any cytotoxicity effect; therefore, further study was taken to investigate the active substances from the extract.Methods: Bioassay-guided isolation of anti-HCV was conducted using Huh-7.5 cells infected with HCV J6/JFH1 in the presence of extracts, fractions, or compounds from the plant.Results: Ethyl acetate fraction (Fr E) exhibited high anti-HCV activity with IC 50 value of 1.7 µg/ml. Further, separation of Fr E by open column chromatography resulted in nine sub-fractions (sub-Fr E1-E9). Sub-Fr E3 and E4 have IC 50 value of 29.90 µg/ml and 7.68 µg/ml, respectively. Polyphenols compounds have been isolated from sub-Fr E3 and E4. The structures have been determined to be ethyl gallate (1), methyl gallate (2), catechin (3), gallic acid (4), and quercetin 3-O-rhamnoside (5). Among the isolated compounds, gallic acid showed to possess strong anti-HCV activity with IC 50 value of 15.9 µg/ml. Conclusion:T. sureni and its isolated compound, gallic acid, may be good candidates to develop for alternative and/or complementary agents of anti-HCV infection.

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“…The cytotoxicity assay/cell compatibility assay was conducted as previously described by Enkhtaivan et al 6. using Madin-Darby Canine Kidney (MDCK) cell lines (ATCC, CCL-34) purchased from American Type Tissue Culture collection, USA.…”

Section: Methodsmentioning

confidence: 99%

The ethanopharmacological aspect of carbon nanodots in turmeric smoke

Chun

Muthu

Enkhtaivan

et al. 2016

Sci Rep

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Smoke manifested ever since our ancient’s lit fire; today it has evolved to become an environmental concern. However, medicinal smoke is still part of man’s natural remedies, religious and cultural practices too. The Asiatic household practice of burning turmeric rhizomes to relieve nose and chest congestion is a well known yet never scientifically authenticated or studied practice. For the first time we investigate the components of these turmeric smudges, validate their antimicrobial and anticancer properties and their cell compatibility. With smoke there is always nanoparticulate carbon and turmeric smoke is no exception. If so, what is the role of the nano carbon (NC) in the turmeric smudge effect? This study isolated, characterized and exposed these secret natural NC undercover agents in turmeric smoke. Their unequivocal role in the ethanopharmocological activity of turmeric smudging has been demonstrated. This work opens a new avenue for use of such nano components of smoke for harnessing the ethanopharmacological property of various medicinal smokes, by excluding the smoke factor, through extracting the nano carbon material in them. This is a possibility to realizing the use of such naturally available nanomaterial, as an eco friendly substitute for the notorious anthropogenic nanomaterials.

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Anti-influenza (H1N1) potential of leaf and stem bark extracts of selected medicinal plants of South India

Cited by 29 publications

References 20 publications

A Critical Review of Phenolic Compounds Extracted from the Bark of Woody Vascular Plants and Their Potential Biological Activity

A Critical Review of Phenolic Compounds Extracted from the Bark of Woody Vascular Plants and Their Potential Biological Activity

Antihepatitis C Virus Activity of Indonesian Mahogany (Toona Sureni)

The ethanopharmacological aspect of carbon nanodots in turmeric smoke

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