Anti-influenza A virus activity of uridine derivatives of 2-deoxy sugars

Biological Evaluation of Uridine Derivatives of 2-Deoxy Sugars as Potential Antiviral Compounds against Influenza A Virus

“…We have shown that these two compounds affect protein glycosylation similarly to tunicamycin, but they are significantly less toxic. Moreover, our other previous report consistently confirmed that both IW3 and IW7 compounds, due to the universal mechanism of action, were also active against influenza A virus H5N2 and H1N1 strains at non-toxic concentrations targeting the maturation of viral proteins [ 34 ]. This unique effect of both compounds on the HA protein prompted our further studies focused on the examination of the effect of a wide array of other synthesized compounds on the yield of influenza virus.…”

“…Recently, we reported that 2-deoxy sugar derivatives of uridine, compounds IW3 and IW7 ( Figure 1 ), exhibited efficient inhibitory effects against H5N2 and H1N1 influenza A viruses in Madin-Darby canine kidney (MDCK) cells [ 34 ]. In the current work, we investigated the effect of various protecting groups on antiviral activity.…”

“…We have previously shown that two synthesized by us 2-deoxy sugar derivatives of uridine (compounds IW3 and IW7), belonging to N -glycosylation inhibitors, effectively blocked influenza A virus propagation by affecting the synthesis of viral glycoproteins [ 34 ]. Due to the fact that the new compounds were synthesized as derivatives of IW3 and IW7 compounds, we wanted to check the effects of further modifications of these compounds on viral glycoprotein synthesis.…”

“…They contain uridine moiety and mimic the uridine diphosphate (UDP)-sugar natural substrates. We have previously reported that two compounds from this series—2-deoxy sugar derivatives of uridine (IW3 and IW7) ( Figure 1 )—showed good anti-influenza virus activity in vitro with IC 50 of 72 and 63 µM, respectively [ 34 ]. It was concluded that IW3 and IW7 block the influenza virus by targeting the glycan process during the synthesis of viral glycoproteins.…”

Design, Synthesis, and Evaluation of Novel 2-Methoxyestradiol Derivatives as Apoptotic Inducers through an Intrinsic Apoptosis Pathway

“…In recent years, uridine, uracil, and thymine (2, 3, and 4, Figure 1) have attracted much interest due to their promising potential biological activities, and their modified derivatives have exhibited excellent activities, such as antibacterial, inhibition against 1,4-β-galactosyltransferase, antivirus, anticancer, and so on [29][30][31][32][33][34][35][36]. Our previous studies [37,38] have also shown that uridine/uracil/thymine attached to the natural compound oleanolic acid could afford derivatives that possess high anti-proliferative activities against tumor cell lines and exhibit clearly inducing effects on cell apoptosis.…”