Neoechinulin B and its analogues as potential entry inhibitors of influenza viruses, targeting viral hemagglutinin

Chen, Xueqing; Si, Longlong; Liu, Dong; Proksch, Peter; Zhang, Lihe; Zhou, Demin; Lin, Wenhan

doi:10.1016/j.ejmech.2015.02.006

Cited by 93 publications

(90 citation statements)

References 59 publications

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“…This compound was very recently characterized from a marine-derived fungus Eurotium rubrum by Chen and co-workers and was named as rubrumline M ( 5 ) [26]. A literature searching result showed that only two indolediketopiperazine derivatives of preechinulin class, rubrumline M ( 5 ) and arestrictin A [27], had been isolated and characterized with a hydroxyl group substituted at C-8.…”

Section: Resultsmentioning

confidence: 99%

Indolediketopiperazine Alkaloids from Eurotium cristatum EN-220, an Endophytic Fungus Isolated from the Marine Alga Sargassum thunbergii

et al. 2017

Marine Drugs

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Four new indolediketopiperazine derivatives (1–4), along with nine known congeners (5–13), were isolated and identified from the culture extract of Eurotium cristatum EN-220, an endophytic fungus obtained from the marine alga Sargassum thunbergii. The structures of thesecompounds were elucidated on the basis of extensive spectroscopic analysis and the absolute configurations of compounds 1–4 were established by NOESY experiments and by chiral HPLC analyses of their acid hydrolysates. The absolute configuration of C-8 (a quaternary carbon substituted with a hydroxyl group) in 5 of preechinulin class was firstly determined by electronic circular dichroism (ECD) calculations. All these compounds were evaluatedfor brine shrimp (Artemia salina) lethality and nematicidal activity as well as antioxidativeand antimicrobial potency.

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Section: Resultsmentioning

confidence: 99%

Indolediketopiperazine Alkaloids from Eurotium cristatum EN-220, an Endophytic Fungus Isolated from the Marine Alga Sargassum thunbergii

et al. 2017

Marine Drugs

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“…gave the prenylated indole diketopiperazines 302-316 221. The co-isolated alkaloid neoechinulin B222,223 was shown to be a potent inhibitor of H1N1 virus and a panel of other inuenza virus strains through binding to viral hemagglutinin disrupting the attachment of viruses to host cells 221. Further new metabolites were obtained from the genera Gliomastix (macrolides 317-321 (ref.…”

mentioning

confidence: 99%

Marine natural products

et al. 2017

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Covering: 2015. Previous review: Nat. Prod. Rep., 2016, 33, 382-431This review covers the literature published in 2015 for marine natural products (MNPs), with 1220 citations (792 for the period January to December 2015) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1340 in 429 papers for 2015), together with the relevant biological activities, source organisms and country of origin. Reviews, biosynthetic studies, first syntheses, and syntheses that lead to the revision of structures or stereochemistries, have been included.

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“…In addition, compound 105 showed cytotoxic activity against K562 with an IC 50 value of 8.3 μmol/L. Chen et al (2015) isolated a series of prenylated IDPs rubrumline A-O (106-120) from the organic extracts of E. rubrum F33 derived from deep sea sediments (− 2067 m) collected in the South Atlantic. In MDCK cells, compound 109 showed potent antiviral activity against H 1 N 1 with an IC 50 value of 126.0 μmol/L and was able to inhibit influenza virus strains including amantadine-and oseltamivir-resistant clinical isolates.…”

Section: Idps From the Fungal Genus Eurotiummentioning

confidence: 99%

Chemical diversity and biological function of indolediketopiperazines from marine-derived fungi

Cao

Wang

2020

Mar Life Sci Technol

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Natural products from marine-derived fungi have attracted considerable attention in the recent two decades. Indolediketopiperazines are one of the most important classes of marine natural products, mainly discovered from the fungal genera Penicillium, Aspergillus and Eurotium. These compounds span a wide range of chemical structures and bioactivities. This review summarizes 155 indolediketopiperazines that were discovered from marine-derived fungi from 2000 to early 2019 and primarily focuses on their chemical diversity and biological function.

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Neoechinulin B and its analogues as potential entry inhibitors of influenza viruses, targeting viral hemagglutinin

Cited by 93 publications

References 59 publications

Indolediketopiperazine Alkaloids from Eurotium cristatum EN-220, an Endophytic Fungus Isolated from the Marine Alga Sargassum thunbergii

Indolediketopiperazine Alkaloids from Eurotium cristatum EN-220, an Endophytic Fungus Isolated from the Marine Alga Sargassum thunbergii

Marine natural products

Chemical diversity and biological function of indolediketopiperazines from marine-derived fungi

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