Anti-inflammatory roles of interleukin-35 in the pathogenesis of Japanese cedar pollinosis

Kouzaki, Hideaki; Arai, Yasuko; Nakamura, Keigo; Murao, Takuya; Tojima, Ichiro; Shimizu, Shino; Abe, Yuta; Shimizu, Takeshi

doi:10.5415/apallergy.2021.11.e34

Cited by 6 publications

(2 citation statements)

References 27 publications

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“…The current finding, Despite the fact that the difference was not statistically significant, it demonstrated an inverse significant difference (P value=0.037), indicated that the serum level of IL-35 was decreased in individuals with allergic rhinitis than in controls. This result was nearly identical with a recent study in Japan achieved by Kouzaki et al,(2021) and Huang et al,(2021) in china who found that the levels of IL-35 in serum were decreased in AR patients than in control group. Also, this result in agreed with Liu et al,(2021), who found patients with allergic rhinitis had lower levels of IL-35 and a higher proportion of ITR35, while ILC2 and type II cytokines were elevated.…”

Section: Discussionsupporting

confidence: 91%

role of IL-35 and IL-22 in patients with allergic rhinitis and their correlation with severity of disease in Najaf province

Al-Saeedi¹,

Shukur

Jaleel³

2022

ijhs

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Introduction: Allergic rhinitis (AR) is a non-infectious disorder of the upper respiratory system that is recognized by nasal obstruction, nasal itching, sneezing, and rhinorrhea induced by inhaled allergens and involves mucosal inflammation. Despite various medicines are available to manage AR but not all have been shown to be effective in all patients, and thus necessitating the development of innovative therapeutics. Objectives: This study was designed to measure the serum levels of IL-22 and IL-35 in Allergic Rhinitis patients and assessing their correlation with disease severity. Materials and Methods: This study included 48 patients with AR and 42 healthy controls. IL-35 and IL-22 were measured using ELAISA kits while the Allergic sensitization of patients was demonstrated by measuring IgE and Eosinophil count. Severity scores of AR patients were calculated using ARIA's recommendations for Total Nasal Symptoms Score (TNSS). The AR patients were divided into three groups based on these scores: mild (n=16), moderate (n=12), and severe (n=20). Results: Serum levels of IL-35 and IL-22 were compared between AR patients and control group: IL-22 was indicated as higher (P=0.0001) in AR patients while the levels of IL-35 detected an inverse result as being lower (P=0.037) in AR patients than control group.

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Section: Discussionsupporting

confidence: 91%

role of IL-35 and IL-22 in patients with allergic rhinitis and their correlation with severity of disease in Najaf province

Al-Saeedi¹,

Shukur

Jaleel³

2022

ijhs

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“…Given the limited number of human studies, Wang et al showed that IL-35 suppresses IL-4 secretion in patients with allergic asthma and that IL-35 levels are lower than healthy controls (Wang et al, 2015). Furthermore, in studies by Bayrak Degirmenci et al ( 2018) and Kouzaki et al (2021), serum IL-35 levels were lower in patients with AR than in the control group.…”

Section: Discussionmentioning

confidence: 99%

Il-10 and Il-35 as Inflammation Regulators in Patients With Allergic Rhinitis and Mild Atopic Asthma

2022

aijbls

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Background. Significantly less is known about the immunoregulative cytokines, especially in allergic airway disease. This study aims to present the involvement of IL-35 and IL-10 in patients with allergic rhinitis (AR) and allergic bronchial asthma (BA). Methodology. The study comprised 71 patients –AR, patients with concomitant AR and mild atopic BA, and healthy controls (HC). We examined the serum levels of IL-35 and IL-10, along with other instrumental examinations, between March and September 2021. Findings. Levels of the regulatory cytokines IL-35 and IL-10 were significantly lower in patients than in HC (87.19±11.90 vs. 96.12±1.79 pg/ml; and 30.26±17.55 vs. 111.56±65.03 pg/ml, respectively). Furthermore, threefold higher serum IL-10 levels were found in healthy subjects compared to patients (p = 0.006). No difference in the levels of interleukins was found between the studied groups. Conclusions. Our results indicate that elevated IL-35 and IL-10 may play an essential role in reducing the activity of underlying allergic inflammation in allergic respiratory diseases, although no difference in the levels of the studied cytokines was found between the different groups of patients. Therefore, we can speculate that the immunosuppressive cytokines IL-35 and IL-10 were involved in maintaining the healthy state of no inflammation.

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A glance on the role of IL-35 in systemic lupus erythematosus (SLE)

Bahadorian,

Faraj,

Kheder

et al. 2024

Cytokine

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Anti-inflammatory roles of interleukin-35 in the pathogenesis of Japanese cedar pollinosis

Cited by 6 publications

References 27 publications

role of IL-35 and IL-22 in patients with allergic rhinitis and their correlation with severity of disease in Najaf province

role of IL-35 and IL-22 in patients with allergic rhinitis and their correlation with severity of disease in Najaf province

Il-10 and Il-35 as Inflammation Regulators in Patients With Allergic Rhinitis and Mild Atopic Asthma

A glance on the role of IL-35 in systemic lupus erythematosus (SLE)

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