Anti-Inflammatory Role of Cannabidiol and O-1602 in Cerulein-Induced Acute Pancreatitis in Mice

Li, Kun; Feng, Jia-yan; Li, Yongyu; Yuece, Birol; Lin, Xiaoqing Diana; Yu, L.-Y.; Li, Yanna; Feng, Yuheng; Storr, Martin

doi:10.1097/mpa.0b013e318259f6f0

Cited by 70 publications

(61 citation statements)

References 37 publications

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“…These studies concluded that endocannabinoids and exogenous cannabinoids may be implicated in the severity of AP, despite a dual effect (protection vs worsening) was also observed, depending of the phase of the disease. The mechanisms remain unclear and may involve sensory nerves or visceral arterial pressure, as well as pro-inflammatory processes [34][35][36][37][38][39].…”

Section: Discussionmentioning

confidence: 99%

Prospective evaluation of the aetiological profile of acute pancreatitis in young adult patients

Culetto

Bournet

Haennig

et al. 2015

Digestive and Liver Disease

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Section: Discussionmentioning

confidence: 99%

Prospective evaluation of the aetiological profile of acute pancreatitis in young adult patients

Culetto

Bournet

Haennig

et al. 2015

Digestive and Liver Disease

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“…The lysate was analyzed by western blotting according to the method described[21]. The protein detection procedure adopted the enhanced chemiluminescence method (Cat No.…”

Section: Methodsmentioning

confidence: 99%

Anti-inflammatory effect of cannabinoid agonist WIN55, 212 on mouse experimental colitis is related to inhibition of p38MAPK

Feng¹,

Li²,

Lin³

et al. 2016

WJG

Self Cite

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AIMTo investigate the anti-inflammatory effect and the possible mechanisms of an agonist of cannabinoid (CB) receptors, WIN55-212-2 (WIN55), in mice with experimental colitis, so as to supply experimental evidence for its clinical use in future.METHODSWe established the colitis model in C57BL/6 mice by replacing the animals’ water supply with 4% dextran sulfate sodium (DSS) for 7 consecutive days. A colitis scoring system was used to evaluate the severity of colon local lesion. The plasma levels of proinflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6), and the myeloperoxidase (MPO) activity in colon tissue were measured. The expressions of cannabinoid receptors, claudin-1 protein, p38 mitogen-activated protein kinase (p38MAPK) and its phosphorylated form (p-p38) in colon tissue were determined by immunohistochemistry and Western blot. In addition, the effect of SB203580 (SB), an inhibitor of p38, was investigated in parallel experiments, and the data were compared with those from intervention groups of WIN55 and SB alone or used together.RESULTSThe results demonstrated that WIN55 or SB treatment alone or together improved the pathological changes in mice with DSS colitis, decreased the plasma levels of TNF-α, and IL-6, and MPO activity in colon. The enhanced expression of claudin-1 and the inhibited expression of p-p38 in colon tissues were found in the WIN55-treated group. Besides, the expression of CB1 and CB2 receptors was enhanced in the colon after the induction of DSS colitis, but reduced when p38MAPK was inhibited.CONCLUSIONThese results confirmed the anti-inflammatory effect and protective role of WIN55 on the mice with experimental colitis, and revealed that this agent exercises its action at least partially by inhibiting p38MAPK. Furthermore, the results showed that SB203580, affected the expression of CB1 and CB2 receptors in the mouse colon, suggesting a close linkage and cross-talk between the p38MAPK signaling pathway and the endogenous CB system.

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“…Additionally, CBD is under investigation in assorted clinical trials as an anti-epileptic (Devinsky et al 2014). Preclinical studies reported that CBD elicits anticonvulsant (Consroe et al 1982; Martin et al 1987), anti-inflammatory (Li et al 2013; Malfait et al 2000), and anti-tumorgenic (McAllister et al 2007) effects. Although its mechanism of action remains to be elucidated, it is known to inhibit adenosine uptake (Liou et al 2008), down-regulate the enzymes FAAH and 5-lipoxygenase (Capasso et al 2008; Massi et al 2008), and bind both transient receptor potential vanilloid 1 (TRPV1) (Iannotti et al 2014) and 5-hydroxytryptamine (serotonin) receptor 1A (5-HT1A) receptors (Russo et al 2005).…”

Section: Phytocannabinoidsmentioning

confidence: 99%

Turning Over a New Leaf: Cannabinoid and Endocannabinoid Modulation of Immune Function

Cabral

Rogers

Lichtman

2015

J Neuroimmune Pharmacol

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Cannabis is a complex substance that harbors terpenoid-like compounds referred to as phytocannabinoids. The major psychoactive phytocannabinoid found in cannabis ∆9-tetrahydrocannabinol (THC) produces the majority of its pharmacological effects through two cannabinoid receptors, termed CB1 and CB2. The discovery of these receptors as linked functionally to distinct biological effects of THC, and the subsequent development of synthetic cannabinoids, precipitated discovery of the endogenous cannabinoid (or endocannabinoid) system. This system consists of the endogenous lipid ligands N- arachidonoylethanolamine (anandamide; AEA) and 2-arachidonylglycerol (2-AG), their biosynthetic and degradative enzymes, and the CB1 and CB2 receptors that they activate. Endocannabinoids have been identified in immune cells such as monocytes, macrophages, basophils, lymphocytes, and dendritic cells and are believed to be enzymatically produced and released “on demand” in a similar fashion as the eicosanoids. It is now recognized that other phytocannabinoids such as cannabidiol (CBD) and cannabinol (CBN) can alter the functional activities of the immune system. This special edition of the Journal of Neuroimmune Pharmacology (JNIP) presents a collection of cutting edge original research and review articles on the medical implications of phytocannabinoids and the endocannabinoid system. The goal of this special edition is to provide an unbiased assessment of the state of research related to this topic from leading researchers in the field. The potential untoward effects as well as beneficial uses of marijuana, its phytocannabinoid composition, and synthesized cannabinoid analogs are discussed. In addition, the role of the endocannabinoid system and approaches to its manipulation to treat select human disease processes are addressed.

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Anti-Inflammatory Role of Cannabidiol and O-1602 in Cerulein-Induced Acute Pancreatitis in Mice

Cited by 70 publications

References 37 publications

Prospective evaluation of the aetiological profile of acute pancreatitis in young adult patients

Prospective evaluation of the aetiological profile of acute pancreatitis in young adult patients

Anti-inflammatory effect of cannabinoid agonist WIN55, 212 on mouse experimental colitis is related to inhibition of p38MAPK

Turning Over a New Leaf: Cannabinoid and Endocannabinoid Modulation of Immune Function

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