Anti-Inflammatory Properties of Zanthoxylum Ovalifolium Weight Methanolic Extract on Albino Wistar Rats

Abstract

Objective: The object of the present study, the methanolic leaf extract of Zanthoxylum ovalifolium was examined for anti-inflammatory activity and tested using carrageenan-induced paw edema in albino Wistar rats.
 Materials and Methods: The rats were grouped into five, each group consisting of six animals, Group I (negative control) received 1 ml of saline, Group II (standard) received 10 mg/kg p. o. of indomethacin, and remaining three groups received three different doses (100, 200, and 400 mg/kg p. o.) of the methanolic leaf extract after 1 h 0.1 ml of 1% carrageenan injection. The result of anti-inflammatory activity was set up to be dose-dependent in the carrageenan-induced paw edema model.
 Results: The methanolic leaf extract has shown significant (p<0.001) inhibition of paw edema, 66%, 66.03%, and 69.29% on the 3rd h at the doses of 100, 200, and 400 mg/kg, p. o., respectively. The results were expressed as the Mean±standard error of mean and statistical significance was analyzed by ANOVA followed by Dunnett’s test. The methanolic leaf of Z. ovalifolium extract showed significant anti-inflammatory activity compared with the standard drug indomethacin.
 Conclusion: Methanolic leaf extract of Z.ovalifolium showed excellent results in the anti-inflammatory experiment so, the plant can be explored as a potential medicine in suppressing inflammation.

Identification of Dipeptidyl Peptidase-4 and α-Amylase Inhibitors from Melicope glabra (Blume) T. G. Hartley (Rutaceae) Using Liquid Chromatography Tandem Mass Spectrometry, In Vitro and In Silico Methods

“…Dietary plants were reported to act on diverse targets of metabolic maladies through different mechanisms and modes intended for distinctive therapeutic effects in the disease and/or its complications. The literature has reported many plants with therapeutic properties and Rutaceae plants are one of the medicinal plants with widely described bioactivities, including antidiabetic [1], antibacterial [2], anticancer [3], and anti-inflammatory activities [4]. Melicope glabra (Blume) T. G. Hartley, a plant belonging to Rutaceae, is among the significant sources of flavonoids and coumarins [5,6].…”