Anti-inflammatory properties of molecular hydrogen: investigation on parasite-induced liver inflammation

Gharib, Bouchra; Hanna, S. M.; Abdallahi, Ould Mohamed Salem; Lépidi, Hubert; Gardette, B; Reggi, Max de

doi:10.1016/s0764-4469(01)01350-6

Cited by 146 publications

(111 citation statements)

References 15 publications

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“…Nevertheless, its therapeutic potential for cancer was revealed in the USA [35], for inflammation in England [36] and in France [37]. In 2007, experimental work by the research team of Professor Shigeo Ohta reactivated interest in the therapeutic benefits of H 2 and provided convincing evidence supporting the importance of hydrogen to cellular function in the body [11,38].…”

Section: Experimental Research On Biological and Therapeutic Propertimentioning

confidence: 99%

Physico-Chemical, Biological and Therapeutic Characteristics of Electrolyzed Reduced Alkaline Water (ERAW)

Henry

Chambron

2013

Water

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Abstract:The consumption of alkaline reduced water produced by domestic electrolysis devices was approved in Japan in 1965 by the Ministry of Health, Labour and Welfare for the cure of gastro-intestinal disorders. Today, these devices are freely available in several countries and can be easily purchased without reserve. The commercial information included with the device recommends the consumption of 1-1.5 L of water per day, not only for gastro-intestinal disorders but also for numerous other illnesses such as diabetes, cancer, inflammation, etc. Academic research in Japan on this subject has been undergoing since 1990 only but has established that the active ingredient is dissolved dihydrogen that eliminates the free radical HO• in vivo. In addition, it was demonstrated that degradation of the electrodes during functioning of the device releases very reactive nanoparticles of platinum, the toxicity of which has not yet been clearly proven. This report recommends alerting health authorities of the uncontrolled availability of these devices used as health products, but which generate drug substances and should therefore be sold according to regulatory requirements.

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Section: Experimental Research On Biological and Therapeutic Propertimentioning

confidence: 99%

Physico-Chemical, Biological and Therapeutic Characteristics of Electrolyzed Reduced Alkaline Water (ERAW)

Henry

Chambron

2013

Water

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“…However, accumulating evidence has demonstrated the attractive achievements of medical gases, especially hydrogen gas, in the treatment of various types of diseases including ischemic heart disease, stroke, sepsis, acute lung injury and inflammatory bowel disease (1-3). Gharib et al placed an animal model of chronic infectious hepatitis into a hydrogen hyperbaric chamber and found that the hydrogen significantly reduced liver injury and fibrosis, improved hemodynamics and increased nitric oxide synthase 2 and antioxidant enzyme activity (4).…”

Section: Introductionmentioning

confidence: 99%

Hydrogen gas inhalation protects against liver ischemia/reperfusion injury by activating the NF-κB signaling pathway

Zhang

Tang

et al. 2015

Experimental and Therapeutic Medicine

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Abstract. Hydrogen has been demonstrated to function as a novel antioxidant and exert therapeutic antioxidant activity in a number of diseases. The present study was designed to investigate the effect of hydrogen inhalation on liver ischemia/reperfusion (I/R) injury in rats. The portal triad to the left lobe and the left middle lobe of the liver were completely occluded for 90 min. This was followed by reperfusion for 180 min. The rats subsequently underwent syngeneic orthotopic liver transplantation. Inhalation of various concentrations (1, 2 and 3%) of hydrogen gas and its administration for different durations (1, 3 and 6 h) immediately prior to the I/R injury allowed the optimal dose and duration of administration to be determined. Liver injury was evaluated through biochemical and histopathological examinations. The expression levels of proinflammatory cytokines, including tumor necrosis factor (TNF)-α and interleukin (IL)-6, were measured by enzyme-linked immunosorbent assay and quantitative polymerase chain reaction (qPCR). Liver nuclear factor κB (NF-κB) was detected by qPCR and western blot analysis. Inhalation of hydrogen gas at 2% concentration for 1 h significantly reduced the serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities, the expression of cytokines, including IL-6, TNF-α, early growth response protein 1 (Egr-1) and IL-1β, and morphological damage. In addition, the mRNA and protein expression levels of NF-κB, heme oxygenase-1 (HO-1), B-cell lymphoma 2 (Bcl-2) and zinc finger protein A20 (A20) in rats where only the donors received hydrogen were significantly increased compared with those in rats where both the donor and recipient, or only the recipient received hydrogen. The results indicate that hydrogen inhalation at 2% concentration for 1 h prior to liver transplantation protected the rats from ischemia/reperfusion injury by activation of the NF-κB signaling pathway.

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“…15) Further, hydrogen-rich water was demonstrated to have salutary effects in prevention of lifestyle diseases such as type 2 diabetes and insulin resistance, 16) and liver inflammation. 17) Since hydrogen rich water is generated by the reaction of magnesium metal with water, we postulated that hydrogen-rich ARW produced by the same reaction would be effective against obesity. To address this issue, we adopted an HF DIO mice model mimicking the pathogenesis of human obesity, 18) to investigate the anti-obesity effect of ARW by way of clinico-pathological parameters, biochemical measurements, histopathological analysis of liver, the expression of cholesterol metabolism-related genes in the liver, and serum levels of adipokine and cytokine.…”

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confidence: 99%

Anti-obesity Effect of Alkaline Reduced Water in High Fat-Fed Obese Mice

Ignacio

Kang

Kim

et al. 2013

Biological & Pharmaceutical Bulletin

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Whether or not alkaline reduced water (ARW) has a positive effect on obesity is unclear. This study aims to prove the positive effect of ARW in high-fat (HF) diet-induced obesity (DIO) in C57BL/6 mice model. Toward this, obesity was induced by feeding the C57BL/6 male mice with high-fat diet (w/w 45% fat) for 12 weeks. Thereafter, the animals were administered with either ARW or tap water. Next, the degree of adiposity and DIO-associated parameters were assessed: clinico-pathological parameters, biochemical measurements, histopathological analysis of liver, the expression of cholesterol metabolism-related genes in the liver, and serum levels of adipokine and cytokine. We found that ARW-fed mice significantly ameliorated adiposity: controlled body weight gain, reduced the accumulation of epididymal fats and decreased liver fats as compared to control mice. Accordingly, ARW coordinated the level of adiponectin and leptin. Further, mRNA expression of cytochrome P450 (CYP)7A1 was upregulated. In summary, our data shows that ARW intake inhibits the progression of HF-DIO in mice. This is the first note on anti-obesity effect of ARW, clinically implying the safer fluid remedy for obesity control.Key words alkaline reduced water; adiponectin; cytokine; adiposity; epididymal fat; cholesterol 7α-hydroxylase Obesity has reached global epidemic status. In developed and developing countries, obesity is reported to be the sixth most important risk factor contributing to the overall burden of chronic disease.1) Forty three million children, 82% of which from developing countries, are affected with obesity.2)The World Health Organization recently reported that there were more than 1 billion overweight adults worldwide, of whom 500 million were obese.3) Obesity poses a major public health issue as it is known to be positively associated with increased risk of certain chronic diseases such as cardiovascular disease, hypertension, type 2 diabetes and fatty liver. [3][4][5] Excessive intake of dietary fats influences the progression of obesity, 6) which is characterized by accumulation of body fats marked by abnormal increase in adipose tissue mass and liver fats (adiposity), dysregulated levels of adipokines, and imbalance between pro-and anti-inflammatory cytokine. 7-9)The complexity of these pathogenetic mechanisms of obesity poses a challenge to the development of effective therapy. In that context, there has been growing concern for the need of newer therapeutic strategies that directly deal with these mechanisms. Of several such candidates, we first introduced the alkaline reduced water (ARW) for obesity control in highfat (HF) diet-induced obesity (DIO) in mice model. ARW refers to electrolyzed water produced from minerals such as magnesium and calcium, which is characterized by supersaturated hydrogen, high pH, and a negative oxidation reduction potential. This hydrogen-rich functional water has been introduced as a feasible therapeutic strategy for health promotion and disease prevention. [10][11][12] Our previous studies ...

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Anti-inflammatory properties of molecular hydrogen: investigation on parasite-induced liver inflammation

Cited by 146 publications

References 15 publications

Physico-Chemical, Biological and Therapeutic Characteristics of Electrolyzed Reduced Alkaline Water (ERAW)

Physico-Chemical, Biological and Therapeutic Characteristics of Electrolyzed Reduced Alkaline Water (ERAW)

Hydrogen gas inhalation protects against liver ischemia/reperfusion injury by activating the NF-κB signaling pathway

Anti-obesity Effect of Alkaline Reduced Water in High Fat-Fed Obese Mice

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