Anti-inflammatory natural products

Olajide, Olumayokun A.; Sarker, Satyajit D.

doi:10.1016/bs.armc.2020.02.002

Cited by 13 publications

(10 citation statements)

References 119 publications

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“…Neuroinflammation is about the activation of the brain's innate immune system in response to an inflammatory challenge and is featured by cellular and molecular host changes across the brain 83 . Cytokines can mediate as well as control immune and inflammatory responses.…”

Section: Antioxidant Activity In Herbs and Fruits And Its Effects On ...mentioning

confidence: 99%

The role of plant‐derived natural antioxidants in reduction of oxidative stress

et al. 2022

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Free radicals are a group of damaging molecules produced during the normal metabolism of cells in the human body. Exposure to ultraviolet radiation, cigarette smoking, and other environmental pollutants enhances free radicals in the human body. The destructive effects of free radicals may also cause harm to membranes, enzymes, and DNA, leading to several human diseases such as cancer, atherosclerosis, malaria, coronavirus disease (COVID‐19), rheumatoid arthritis, and neurodegenerative illnesses. This process occurs when there is an imbalance between free radicals and antioxidant defenses. Since antioxidants scavenge free radicals and repair damaged cells, increasing the consumption of fruits and vegetables containing high antioxidant values is recommended to slow down oxidative stress in the body. Additionally, natural products demonstrated a wide range of biological impacts such as anti‐inflammatory, anti‐aging, anti‐atherosclerosis, and anti‐cancer properties. Hence, in this review article, our goal is to explore the role of natural therapeutic antioxidant effects to reduce oxidative stress in the diseases.

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Section: Antioxidant Activity In Herbs and Fruits And Its Effects On ...mentioning

confidence: 99%

The role of plant‐derived natural antioxidants in reduction of oxidative stress

et al. 2022

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“…Neuroinflammation is described as an innate immune response of the cells in the central nervous systems (CNS) to cope with infection and eliminate pathogens, cell debris, and/or misfolded proteins [1,2]. However, in chronic neurological diseases, neuroinflammation becomes persistent and may pose a threat to neuronal cells.…”

Section: Introductionmentioning

confidence: 99%

Suppression of LPS-Induced Inflammation and Cell Migration by Azelastine through Inhibition of JNK/NF-κB Pathway in BV2 Microglial Cells

Nguyen

Bui

Duong

et al. 2021

IJMS

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The c-Jun N-terminal kinases (JNKs) are implicated in many neuropathological conditions, including neurodegenerative diseases. To explore potential JNK3 inhibitors from the U.S. Food and Drug Administration-approved drug library, we performed structure-based virtual screening and identified azelastine (Aze) as one of the candidates. NMR spectroscopy indicated its direct binding to the ATP-binding site of JNK3, validating our observations. Although the antihistamine effect of Aze is well documented, the involvement of the JNK pathway in its action remains to be elucidated. This study investigated the effects of Aze on lipopolysaccharide (LPS)-induced JNK phosphorylation, pro-inflammatory mediators, and cell migration in BV2 microglial cells. Aze was found to inhibit the LPS-induced phosphorylation of JNK and c-Jun. It also inhibited the LPS-induced production of pro-inflammatory mediators, including interleukin-6, tumor necrosis factor-α, and nitric oxide. Wound healing and transwell migration assays indicated that Aze attenuated LPS-induced BV2 cell migration. Furthermore, Aze inhibited LPS-induced IκB phosphorylation, thereby suppressing nuclear translocation of NF-κB. Collectively, our data demonstrate that Aze exerts anti-inflammatory and anti-migratory effects through inhibition of the JNK/NF-κB pathway in BV2 cells. Based on our findings, Aze may be a potential candidate for drug repurposing to mitigate neuroinflammation in various neurodegenerative disorders, including Alzheimer’s and Parkinson’s diseases.

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“…An additional bioactive iridoid annotated in this work is aucubin. Its beneficial character is confirmed by various studies, exerting anti-nephrotoxic (Potacnjak et al, 2020;Potocnjak et al, 2021), antiinflammatory (Olajide et al, 2020), and anti-osteoporotic effects (Li et al, 2020). Finally, ferulic acid, a common component in several types of honeys, and its analogues possess antioxidant properties and are tested in therapeutic schemes against several diseases (Paiva et al, 2013).…”

Section: Anama Honey Secondary Metabolites-chemical Markersmentioning

confidence: 91%

Characterization of Ikaria Heather Honey by Untargeted Ultrahigh-Performance Liquid Chromatography-High Resolution Mass Spectrometry Metabolomics and Melissopalynological Analysis

Kasiotis

Baira

Iosifidou³

et al. 2022

Front. Chem.

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Honey represents a valuable food commodity, known since ancient times for its delicate taste and health benefits due to its specific compositional characteristics, mainly the phenolic compound content. “Anama” honey is a monofloral honey produced from the nectar of Erica manipuliflora plant, a heather bush of the Greek island of Ikaria, one of the Mediterranean’s longevity regions. “Anama” is characterized by a unique aroma and taste, with a growing demand for consumption and the potential to be included in the list of products with a protected designation of origin. The aim of this study was to determine the chemical and botanical profile of authentic Anama honey samples and find similarities and differences with honey samples of a different botanical origin from the same geographical area. Untargeted Ultrahigh-Performance Liquid Chromatography-Hybrid Quadrupole-Orbitrap High-Resolution Mass Spectrometry (UHPLC-HRMS) metabolomics study was conducted on authentic heather, pine, and thyme honey samples from Ikaria and neighboring islands. The Principal Component Analysis (PCA), Orthogonal Projections to Latent Structures Discriminant Analysis (OPLS-DA), and differential analysis were performed using the entire metabolic profile of the samples and allowed the identification of chemical markers for sample discrimination. Thirty-two characteristic secondary metabolites (cinnamic acids, phenolic acids, flavonoids, terpenes) and other bioactive phenolic compounds, some of them not previously reported in a heather honey (aucubin, catalpol, domesticoside, leonuriside A, picein among others), emerged as potential chemical indicators of Anama honey. Melissopalynological analysis was also carried out to decipher the botanical and geographical origin of Anama honey. The relative frequency of the pollen of dominant plants of the Ericaceae family and a multitude of nectariferous and nectarless plants contributing to the botanical profile of Anama was evaluated. The identification of the pollen sources enabled a potential correlation of differentially increased secondary metabolites and chemicals with their botanical origin. The physicochemical profile of Anama was also determined, including the parameters of pH, color, electrical conductivity, diastase, moisture, as well as sugars, supporting the high quality of this heather honey.

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Anti-inflammatory natural products

Cited by 13 publications

References 119 publications

The role of plant‐derived natural antioxidants in reduction of oxidative stress

The role of plant‐derived natural antioxidants in reduction of oxidative stress

Suppression of LPS-Induced Inflammation and Cell Migration by Azelastine through Inhibition of JNK/NF-κB Pathway in BV2 Microglial Cells

Characterization of Ikaria Heather Honey by Untargeted Ultrahigh-Performance Liquid Chromatography-High Resolution Mass Spectrometry Metabolomics and Melissopalynological Analysis

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