Anti-inflammatory meroterpenoids from the mangrove endophytic fungus Talaromyces amestolkiae YX1

Chen, Senhua; Ding, Meng; Liu, Weiyang; Huang, Xishan; Liu, Zhaoming; Lü, Yongjun; Liu, Hongju; She, Zhigang

doi:10.1016/j.phytochem.2017.11.011

Cited by 70 publications

(51 citation statements)

References 32 publications

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“…There has been a tremendous increase in pharmacological research on anti-inflammatory of marine-derived molecules, and more than 150 anti-inflammatory compounds derived from marine fungi have been reported past two decades [ 37 , 38 ]. The anti-inflammatory compounds are classified into different chemical classes, such as terpenes [ 39 , 40 ], steroids [ 41 ], polyketides [ 15 ], alkaloids [ 42 ], and peptides [ 43 ]. For example, tanzawaic acid Q (isolated from a marine-derived fungus, Penicillium steckii 108YD142) inhibited the lipopolysaccharide (LPS)-induced inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) proteins and mRNA expressions in RAW 264.7 macrophages.…”

Section: Resultsmentioning

confidence: 99%

Secondary Metabolites with Nitric Oxide Inhibition from Marine-Derived Fungus Alternaria sp. 5102

et al. 2020

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Two new benzofurans, alternabenzofurans A and B (1 and 2) and two new sesquiterpenoids, alternaterpenoids A and B (3 and 4), along with 18 known polyketides (5−22), were isolated from the marine-derived fungus Alternaria sp. 5102. Their structures were elucidated on the basis of extensive spectroscopic analyses (1D and 2D NMR, HR-ESIMS, and ECD) and X-ray crystallography, as well as the modified Mosher’s method. Compounds 2, 3, 5, 7, 9–18, and 20–22 exhibited potent anti-inflammatory activity by inhibiting the production of NO in RAW264.7 cells activated by lipopolysaccharide with IC50 values in the range from 1.3 to 41.1 μM. Structure-activity relationships of the secondary metabolites were discussed.

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Section: Resultsmentioning

confidence: 99%

Secondary Metabolites with Nitric Oxide Inhibition from Marine-Derived Fungus Alternaria sp. 5102

et al. 2020

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“…The compounds exhibited activities through inhibition of NO and total ROS. Phomopchalasin C (15) was identified as the most active inhibitor of NO production in LPS-induced raw cells with an IC 50 value of 11.2 µM (▶ Table 2) [20,42,50].…”

Section: Ai Cytochalasansmentioning

confidence: 99%

“…3). Periconianone A (20) and periconianone B (21) were found to inhibit LPS-induced NO production in mouse microglia BV2 cells with IC 50 values of 0.15 and 0.38 µM, respectively. Nevertheless, all the sesquiterpenes were proven to possess good AI activity (▶ Table 2) [15,31,38,39,47].…”

Section: Ai Sesquiterpenes and Sesquiterpenoidsmentioning

confidence: 99%

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Prospective Leads from Endophytic Fungi for Anti-Inflammatory Drug Discovery

2020

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A wide array of therapeutic effects has been exhibited by compounds isolated from natural sources. “Bio-actives of endophytic origin” is a recently explored area that came into recognition over the last 2 decades. Literature search on the secondary metabolites of endophytes have shown several pharmacologically active compounds especially anti-inflammatory compounds, which have been reviewed in the present paper. The article is structured based on the chemical classification of secondary metabolites. The compounds were identified to possess activity against a total of 16 anti-inflammatory targets. The most common targets involved were NO, TNF-α, and inhibition of total ROS. Further, the article gives a detailed insight into the compounds, their endophytic source, and anti-inflammatory target as well as potency. The contents of the article cover all the scientific reports published until Feb. 2019. Thus 118 compounds and 6 extracts have been reported to be obtained from endophytic sources showing anti-inflammatory activities. Amongst these, herbarin, periconianone A, and periconianone B were identified as the most potent compounds in terms of their IC50 values against NO inhibition.

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“…Source and biological activities of some triterpenes. bacteria, and fungi [21] (Figure 7). Meroterpene biosynthesis expands the diversity available to isoprenoid pathways alone and allows for the assembly of natural products with highly unique structural attributes.…”

Section: Meroterpenesmentioning

confidence: 99%