Anti-inflammatory function of an in situ cross-linkable conjugate hydrogel of hyaluronic acid and dexamethasone

Ito, Taichi; Fraser, Iain P.; Yeo, Yoon; Highley, Christopher B.; Bellas, Evangelia; Kohane, Daniel S.

doi:10.1016/j.biomaterials.2006.12.012

Cited by 126 publications

(96 citation statements)

References 35 publications

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“…The drugs can be incorporated directly into the scaffolds, i.e., distributed throughout the polymeric matrix during casting, as is the case with many micro-and nanoparticulate drug delivery systems (18) and bulk hydrogels (19,20). Drugs can also be reversibly conjugated to the matrix covalently (21) or by other means. However, other methods of providing drug delivery to scaffold-type systems have arisen that might provide greater flexibility in the types and quantities of drugs that can be delivered.…”

Section: Drug Delivery Functionalitymentioning

confidence: 99%

Polymeric Biomaterials in Tissue Engineering

2008

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Polymeric biomaterials are one of the cornerstones of tissue engineering. A wide range of materials has been used. Approaches have shown increasing sophistication over recent years employing drug delivery functionality, micropatterning, microfluidics, and other technologies. Challenges such as producing threedimensional matrixes and rendering them deliverable through minimally invasive techniques have been addressed. A major recent development is the design of biomaterials for tissue engineering matrices to achieve specific biologic effects on cells, and vice versa.

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Section: Drug Delivery Functionalitymentioning

confidence: 99%

Polymeric Biomaterials in Tissue Engineering

2008

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“…Ito et al designed and synthesized an HA hydrogel that combined in situ crosslinking properties with drug conjugation to obtain a material for the prevention of post-surgical adhesion [61]. HA was conjugated via an ester linkage to the potent steroidal anti-inflammatory drug, dexamethasone, and was also modified with the hydrazide or aldehyde groups to induce crosslinking by means of hydrazone bonds.…”

Section: Ha Conjugates In the Form Of Hydrogelsmentioning

confidence: 99%

Hyaluronic Acid Bioconjugates for the Delivery of Bioactive Molecules

2014

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Hyaluronic acid (HA) has currently several therapeutic applications: in ophthalmology, osteoarthritis, wound healing, tissue regeneration, postoperative anti-adhesion and anesthetic medicine. In the last ten years, it has also been successfully investigated in the field of drug delivery, in the form of conjugates or hydrogel depot systems. HAylation, the covalent conjugation of HA to bioactive molecules, allows the overcoming of disadvantages associated with some pharmaceuticals, such as insolubility, instability and fast kidney clearance. These issues can be addressed also by covalent attachment of polyethylene glycol (PEGylation), but HA has the relevant advantages of biodegradability, high loading and specific targeting. In this review, the novel HA derivatives and the latest advances in HA-based drug delivery with a particular focus on the chemistry of conjugation will be discussed. Although, so far, there are no HA-drug conjugates on the market, several derivatives are presently under clinical investigation, and the promising results encourage further investigations and the exploitation of this versatile polysaccharide.

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“…In vivo Rat Cecal abrasion Adhesion formation attenuated by mAbs to IL1 and IL-1/TNF-a TNF-a, IL-6 [77] …”

Section: Proinflammatory Markersmentioning

confidence: 99%

Cytokine orchestration in post-operative peritoneal adhesion formation

Ra¹,

Redmond²

2008

WJG

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Peritoneal adhesions are a near inevitable occurrence after laparotomy and a major cause of both patient and physician misery. To date, clinical attempts at their amelioration have concentrated on manipulating the physical factors that affect their development despite a wealth of experimental data elucidating the molecular mechanisms that underlie their initiation, development and maturation. However, the advent of targeted, specific anti-cytokine agents as directed therapy for inflammatory and neoplastic conditions raises the prospect of a new era for anti-adhesion strategies. To harness this potential will require considerable crossdisciplinary collaboration and that surgeon-scientists propel themselves to the forefront of this emerging field.

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Anti-inflammatory function of an in situ cross-linkable conjugate hydrogel of hyaluronic acid and dexamethasone

Cited by 126 publications

References 35 publications

Polymeric Biomaterials in Tissue Engineering

Polymeric Biomaterials in Tissue Engineering

Hyaluronic Acid Bioconjugates for the Delivery of Bioactive Molecules

Cytokine orchestration in post-operative peritoneal adhesion formation

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