Anti-Inflammatory Effects of β-Glucan in Cancer Related Fatigue

Richter, Josef; Král,; Stiborová, I; D, Rajnohova; Vĕtvická,

doi:10.15744/2393-9060.2.304

Cited by 7 publications

(6 citation statements)

References 30 publications

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“…A large study using dogs showed regulation of general as well as antigen specific IgA and IgM reactions (Stuyven et al, 2010). Lehne et al (2006) confirmed findings of positive effects of glucan supplementation on improvements of immune reactions (Richter et al, 2015a;2015b;2015c). It is clear that insoluble dietary fiber playsan important role in the regulation of both immune reactions and psychological state.…”

Section: Introductionsupporting

confidence: 58%

Glucan Supplementation Regulates Secretory Immunity and Stress

Richter

Stiborová

Vlastimil

et al. 2017

American Journal of Immunology

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Sixty-six children were supplemented with beta glucan and dietary nucleotides, another 63 children served as negative control. We evaluated the effects of these supplements on several aspects of secretory immunity such as levels of secretory IgA (SIgA), albumin and SIgA/albumin ratio. In addition, in order to monitor effects of physical challenges and compensatory treatments on stress and reparation of immunity, we measured levels of salivary cortisol. We found significant effects of supplementation with beta glucan on secretory IgA in children with increased physical challenge. To fully explain these findings, we will need to add additional indicators of stress and salivary immunity.

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Section: Introductionsupporting

confidence: 58%

Glucan Supplementation Regulates Secretory Immunity and Stress

Richter

Stiborová

Vlastimil

et al. 2017

American Journal of Immunology

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“…Randomly selected groups of children were treated with an oral dose with 100 mg of glucan/day for a period of 30 days. The results showed that this short-term supplementation improved the levels of salivary immunoglobulins (sIgM, sIgG, and sIgA) (Figure 5) [22], decreased eNO levels, and improved physical endurance of children [68]. Further, a short-term food supplementation with glucan also reduced the levels of salivary albumin and calprotectin (Figure 6).…”

Section: Glucan In Clinical Trialsmentioning

confidence: 99%

“…Further, a short-term food supplementation with glucan also reduced the levels of salivary albumin and calprotectin (Figure 6). In addition, the same glucan treatment significantly improved the overall health status and physical conditions of children exposed to passive smoking [68,69]. These studies allowed us to conclude that glucan supplementation is a highly promising and inexpensive method of treatment for chronic respiratory problems in children [70].…”

Section: Glucan In Clinical Trialsmentioning

confidence: 99%

“…Further, a follow-up study found a significant increase of NK cells numbers and activity (Figure 7) suggesting that the addition of glucan to the diet could help the prevention of cancer remission. In addition, the glucan-supplemented group exhibited improvements in psychic conditions, cancer related fatigue, and nutritional state [68,74].…”

Section: Glucan In Clinical Trialsmentioning

confidence: 99%

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Beta Glucan: Supplement or Drug? From Laboratory to Clinical Trials

et al. 2019

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Glucans are part of a group of biologically active natural molecules and are steadily gaining strong attention not only as an important food supplement, but also as an immunostimulant and potential drug. This paper represents an up-to-date review of glucans (β-1,3-glucans) and their role in various immune reactions and the treatment of cancer. With more than 80 clinical trials evaluating their biological effects, the question is not if glucans will move from food supplement to widely accepted drug, but how soon.

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“…In mouse model, glucan attenuated chronic fatigue syndrome [21], whereas in human clinical trials, glucan supplementation resulted in improved endurance of children with chronic respiratory problems [22]. Glucan also has positive effects in cancerrelated fatigue [23], probably via its anti-inflammatory action.…”

Section: Introductionmentioning

confidence: 99%

β-Glucan Improves Conditions of Chronic Fatigue in Mice by Stimulation of Immunity

Větvička¹,

Větvičková²

2020

TOBIOCJ

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Background: Various natural molecules have been studied for the enhancement of physical endurance. Glucan has been found to improve various stress-related conditions and to improve fatigue and endurance. Objective: In our study, we focused on evaluation of glucan effects on some reactions involved in chronic fatigue. Methods: We measured phagocytosis of neutrophils, the production of IL-2, IL-4, and IL-10 by spleen cells, and levels of antioxidant glutathione and oxidative stress marker superoxide dismutase in brain. In addition, we measured the effects of glucan on water immersion and on rotarod. Results: The glucan supplementation strongly improved the suppressed phagocytosis and changes in cytokine and levels of oxidative stress markers caused by fatigue. In addition, glucan supplementation also increased the motor functioning of tested animals. Conclusion: Our data suggested that anti-fatigue properties of glucan are related with its well-established effects as stimulator of immune reactions.

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Anti-Inflammatory Effects of β-Glucan in Cancer Related Fatigue

Cited by 7 publications

References 30 publications

Glucan Supplementation Regulates Secretory Immunity and Stress

Glucan Supplementation Regulates Secretory Immunity and Stress

Beta Glucan: Supplement or Drug? From Laboratory to Clinical Trials

β-Glucan Improves Conditions of Chronic Fatigue in Mice by Stimulation of Immunity

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