Anti-inflammatory effects of vicenin-2 and scolymoside in vitro and in vivo

Kang, Hyejin; Ku, Sae‐Kwang; Jung, Byeongjin; Bae, Jong‐Sup

doi:10.1007/s00011-015-0886-x

Cited by 31 publications

(12 citation statements)

References 103 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The semi-flexible docking results of CDOCKER revealed that pachymic acid and vicenin-2, as examples, formed interactions with HO-1 and ERK, respectively (Supplementary Figure 1). These results for compound-protein interactions between pachymic acid-HO-1 and vicenin-2-ERK were confirmed and validated against published articles (Lu et al, 2010;Kang et al, 2015). In summary, natural small molecules for specific pharmacodynamic targets against cardiovascular diseases could be screened out conveniently, quickly, and successfully by using the CPSD strategy.…”

Section: Cpsd In the Development Of Cardiovascular Disease Drugssupporting

confidence: 67%

Clinical Prescription-Protein-Small Molecule-Disease Strategy (CPSD), A New Strategy for Chinese Medicine Development: A Case Study in Cardiovascular Diseases

Guo

Jiang

et al. 2020

Front. Pharmacol.

View full text Add to dashboard Cite

Chinese medicine is a national treasure that has been passed down for thousands of years in China. According to the statistics of the World Health Organization, there are currently four billion people in the world who use Chinese medicine to treat diseases, accounting for 80% of the world's total population. However, the obscurity of its theory, its unmanageable quality, its complex compositions, and the unknown effective substances and mechanisms are great obstacles to the internationalization of Chinese medicine. Here, we propose a new strategy for the development of Chinese medicine: the clinical prescription (C)-protein (P)-small-molecule (S)-disease (D) strategy, namely the CPSD strategy. The strategy uses clinical prescriptions as the source of medicine and uses computer simulation technology to find small-molecule drugs targeting therapeutic proteins for treating specific diseases so as to deepen awareness of the value of Chinese medicine. At the same time, this article takes cardiovascular drug development as an example to introduce the application of CPSD, which will be instrumental in the further development, modernization, and internationalization of Chinese medicine.

show abstract

Section: Cpsd In the Development Of Cardiovascular Disease Drugssupporting

confidence: 67%

Clinical Prescription-Protein-Small Molecule-Disease Strategy (CPSD), A New Strategy for Chinese Medicine Development: A Case Study in Cardiovascular Diseases

Guo

Jiang

et al. 2020

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…However, the activity observed in this present study did not conform to those results. The flavones scolymoside, present only in the C. subternata extracts, but in substantial quantities, and vicenin-2, with the highest concentration in C. genistoides extracts, elicited anti-inflammatory activity in various systems [36,37]. Nevertheless, their concentration in the extracts also did not correlate with their immune-regulating activity, suggesting that some other compounds or synergistic effects of several molecules would contribute to the activity observed in our experiments.…”

Section: Discussionmentioning

confidence: 58%

Cyclopia Extracts Enhance Th1-, Th2-, and Th17-type T Cell Responses and Induce Foxp3+ Cells in Murine Cell Culture

et al. 2017

View full text Add to dashboard Cite

, one of the traditional South African medicinal plants, and other species of the same genus offer noteworthy phenolic profiles, in particular high levels of the anti-allergic xanthone mangiferin. Hot water and 40% ethanol-water (v/v) extracts, prepared from , and were tested for immune-regulating activity using murine splenocytes and mesenteric lymph node cells. The 40% ethanol-water extracts of significantly enhanced production of several types of cytokines, including IL-4, IL-17, and IFN-, by antigen-stimulated splenocytes. A concentration-dependent response was observed, noticeably for IFN- production. The activity of the extracts did not correlate with the content of any of the major phenolic compounds, indicative that other extract constituents also play a role in immunomodulation. Additionally, the increased ratio of CD4CD25Foxp3 Treg cells to total CD4 cells indicated induction of Foxp3 cells when mesenteric lymph node cells were cultured in the presence of these two extracts. This study is the first reporting immunostimulatory activity for , which are widely consumed as the herbal tea known as honeybush, underpinning further investigations into the potential use of its extracts as adjuvants for mucosal immunotherapy.

show abstract

“…The naringin dihydrochalcone biological effects were not analysed to present days, however its major constituent the naringin was suggested to be the main component of Ganshuang granule that plays an anti-fibrotic role through deactivation of hepatic stellate cells in cirrhotic mouse model [42], and through the attenuation of EGFR/ERK signalling could suppress cancer cell growth [43]. In the case of vicenin-2 has been recently shown that can suppress high-glucose induced vascular inflammatory processes in human umbilical vein endothelial cells and mice, thereby suggesting its effectiveness as a therapeutic agent for vascular inflammatory diseases [44,45].…”

Section: Resultsmentioning

confidence: 99%

Comparative Chemomapping of Phytoconstituents from Different Extracts of Globe Artichoke - Cynara Scolymus L.

et al. 2017

View full text Add to dashboard Cite

ABSTRACT. Artichoke (Cynara scolymus L.) is a well-known herb for its efficiency in the prevention/treatment of liver injuries, among other human chronic diseases. The aim of present study was to analyse the phytoconstituents content of aqueous and hydro-alcoholic extracts obtained from the leaves of artichoke. The chemomapping was carried out using UHPLC-ESI-MS. Several new and some known phytoconstituents were identified in the two type of extracts that have slightly different composition profiles. The newly found phytoconstituents in artichoke, plead for multiple health promoting effects that have presumably more stochastic than determinative features. Therefore, further experiments are needed using such extracts, and based on a system biology approach to clarify the complexity of beneficial effects of artichoke.

show abstract

Anti-inflammatory effects of vicenin-2 and scolymoside in vitro and in vivo

Abstract: Vicenin-2 and scolymoside possess anti-inflammatory functions by inhibiting hyperpermeability,expression of CAMs, and adhesion and migration of leukocytes, thereby endorsing its usefulness as a therapy for vascular inflammatory diseases.

Cited by 31 publications

References 103 publications

Clinical Prescription-Protein-Small Molecule-Disease Strategy (CPSD), A New Strategy for Chinese Medicine Development: A Case Study in Cardiovascular Diseases

Clinical Prescription-Protein-Small Molecule-Disease Strategy (CPSD), A New Strategy for Chinese Medicine Development: A Case Study in Cardiovascular Diseases

Cyclopia Extracts Enhance Th1-, Th2-, and Th17-type T Cell Responses and Induce Foxp3+ Cells in Murine Cell Culture

Comparative Chemomapping of Phytoconstituents from Different Extracts of Globe Artichoke - Cynara Scolymus L.

Contact Info

Product

Resources

About