The Simons Observatory (SO) is a new cosmic microwave background experiment being built on Cerro Toco in Chile, due to begin observations in the early 2020s. We describe the scientific goals of the experiment, motivate the design, and forecast its performance. SO will measure the temperature and polarization anisotropy of the cosmic microwave background in six frequency bands centered at: 27, 39, 93, 145, 225 and 280 GHz. The initial configuration of SO will have three small-aperture 0.5-m telescopes and one large-aperture 6-m telescope, with a total of 60,000 cryogenic bolometers. Our key science goals are to characterize the primordial perturbations, measure the number of relativistic species and the mass of neutrinos, test for deviations from a cosmological constant, improve our understanding of galaxy evolution, and constrain the duration of reionization. The small aperture telescopes will target the largest angular scales observable from Chile, mapping ≈ 10% of the sky to a white noise level of 2 µK-arcmin in combined 93 and 145 GHz bands, to measure the primordial tensor-to-scalar ratio, r, at a target level of σ(r) = 0.003. The large aperture telescope will map ≈ 40% of the sky at arcminute angular resolution to an expected white noise level of 6 µK-arcmin in combined 93 and 145 GHz bands, overlapping with the majority of the Large Synoptic Survey Telescope sky region and partially with the Dark Energy Spectroscopic Instrument. With up to an order of magnitude lower polarization noise than maps from the Planck satellite, the high-resolution sky maps will constrain cosmological parameters derived from the damping tail, gravitational lensing of the microwave background, the primordial bispectrum, and the thermal and kinematic Sunyaev-Zel'dovich effects, and will aid in delensing the large-angle polarization signal to measure the tensorto-scalar ratio. The survey will also provide a legacy catalog of 16,000 galaxy clusters and more than 20,000 extragalactic sources a .

LiteBIRD is a next-generation satellite mission to measure the polarization of the cosmic microwave background (CMB) radiation. On large angular scales the B-mode polarization of the CMB carries the imprint of primordial gravitational waves, and its precise measurement would provide a powerful probe of the epoch of inflation. The goal of LiteBIRD is to achieve a measurement of the characterizing tensor to scalar ratio r to an uncertainty of δr = 0.001. In order to achieve this goal we will employ a kilopixel superconducting detector array on a cryogenically cooled sub-Kelvin focal plane with an optical system at a temperature of 4 K. We are currently considering two detector array options; transition edge sensor (TES) bolometers and microwave kinetic inductance detectors (MKID). In this paper we give an overview of LiteBIRD and describe a TES-based polarimeter designed to achieve the target sensitivity of 2 µK·arcmin over the frequency range 50 to 320 GHz.

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SummaryMany plants contain latex that exudes when leaves are damaged, and a number of proteins and enzymes have been found in it. The roles of those latex proteins and enzymes are as yet poorly understood. We found that papain, a cysteine protease in latex of the Papaya tree (Carica papaya, Caricaceae), is a crucial factor in the defense of the papaya tree against lepidopteran larvae such as oligophagous Samia ricini (Saturniidae) and two notorious polyphagous pests, Mamestra brassicae (Noctuidae) and Spodoptera litura (Noctuidae). Leaves of a number of laticiferous plants, including papaya and a wild ®g, Ficus virgata (Moraceae), showed strong toxicity and growth inhibition against lepidopteran larvae, though no apparent toxic factors from these species have been reported. When the latex was washed off, the leaves of these lactiferous plants lost toxicity. Latexes of both papaya and the wild ®g were rich in cysteine-protease activity. E-64, a cysteine protease-speci®c inhibitor, completely deprived the leaves of toxicity when painted on the surface of papaya and ®g leaves. Cysteine proteases, such as papain, ®cin, and bromelain, all showed toxicity. The results suggest that plant latex and the proteins in it, cysteine proteases in particular, provide plants with a general defense mechanism against herbivorous insects.

Foreseeing the era of high spatial resolution measurements of the Sunyaev-Zel'dovich effect (SZE) in clusters of galaxies, we present a prototype analysis of this sort combined with Chandra X-ray data. It is applied specifically to RX J1347-1145 at z = 0.451, the most X-ray-luminous galaxy cluster known, for which the highest resolution SZE and X-ray images are currently available. We demonstrate that the combined analysis yields a unique probe of complex structures in the intracluster medium, offering determinations of their temperature, density, and line-of-sight extent. For a subclump in RX J1347-1145, previously discovered in our SZE map, the temperature inferred after removing the foreground and background components is well in excess of 20 keV, indicating that the cluster has recently undergone a violent merger. Excluding the region around this subclump, the SZE signals in submillimeter to centimeter bands (350, 150, and 21 GHz) are all consistent with those expected from Chandra X-ray observations. We further present a temperature deprojection technique based on the SZE and X-ray images, without any knowledge of spatially resolved X-ray spectroscopy. The methodology presented here will be applicable to a statistical sample of clusters available in the future SZE surveys.