Anti-inflammatory effects of rutin on HMGB1-induced inflammatory responses in vitro and in vivo

Abstract

Collectively, these results indicate that RT could be a candidate therapeutic agent for treatment of various severe vascular inflammatory diseases via inhibition of the HMGB1 signaling pathway.

Evidence of Bioactive Compounds from Vernonia polyanthes Leaves with Topical Anti-Inflammatory Potential

“…In addition, flavonoids inhibit histamine release, phosphodiesterase, protein kinases, and activation of transcriptase [54,55]. Rutin is able to suppress the production of tumor necrosis factor-α and interleukin 6 and the activation of nuclear factor-κB and extracellular regulated kinases 1/2, which may explain the anti-inflammatory effect writing [56]. Thus, the phytochemicals of V. polyanthes are probably interacting with important inflammatory pathways preventing the actions of mediators implicated in the formation of edema, and can be potential targets for the development of new topical anti-inflamatory therapeutic agents.…”

Anti-inflammatory activity and phenolic composition of Dendropanax morbifera leaf extracts

“…The most abundant phenolic compound in GLE and SLE was rutin (Table 1), which has antiplatelet, antiviral, and antihypertensive properties (Yoo et al, 2014). Rutin has been suggested as a candidate therapeutic agent for the treatment of inflammatory diseases via the inhibition of ERK1/2 activation (Yoo et al, 2014) and/or repression of ROS production (Gao et al, 2013). In addition, chlorogenic acid, (+)−catechin, ferulic acid, myricetin and quercetin were identified in GLE and SLE (Table 1).…”

“…Therefore, to identify the active phenolic compounds that have anti-inflammatory effects, some phenolic compounds were identified and quantified in GLE and SLE using HPLC. The most abundant phenolic compound in GLE and SLE was rutin (Table 1), which has antiplatelet, antiviral, and antihypertensive properties (Yoo et al, 2014). Rutin has been suggested as a candidate therapeutic agent for the treatment of inflammatory diseases via the inhibition of ERK1/2 activation (Yoo et al, 2014) and/or repression of ROS production (Gao et al, 2013).…”

Total glycosides of Yupingfeng protects against bleomycin-induced pulmonary fibrosis in rats associated with reduced high mobility group box 1 activation and epithelial–mesenchymal transition

“…A variety of cytokines, inflammatory mediators, and genetic factors contribute to the process of tissue fibrosis [10][11][12]. High mobility group box 1 (HMGB1), a highly conserved DNA-binding protein, is an important therapeutic target for several diseases [13,14].…”