Anti-inflammatory activity and phenolic composition of Dendropanax morbifera leaf extracts

Hyun, Tae Kyung; Ko, Yeong-Jong; Kim, Eunhye; Chung, Ill‐Min; Kim, Ju-Sung

doi:10.1016/j.indcrop.2015.05.002

Cited by 52 publications

(38 citation statements)

References 43 publications

(48 reference statements)

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“…Since DP-C did not inhibit LPS-induced ERK 1/2 phosphorylation, as shown by Western blotting (Fig. 4C), our results do not support the inhibition of ERK1/2 phosphorylation demonstrated by Hyun et al 29) The role of HO-1 induction via Nrf2 nuclear translocation has been demonstrated to possess beneficial effects in the diseases associated with inflammation. 47) In our study, we found that DP-C induced HO-1 expression via Nrf2 nuclear translocation (Figs.…”

Section: )contrasting

confidence: 89%

“…29) These phenolic compounds may contribute to the anti-inflammatory activity of DP since the previous reports had proved the anti-inflammatory of these phenolic compounds. [37][38][39] In addition, Yu et al showed that a triterpenoid compound, oleifolioside A, isolated from lower stem parts of DP, possessed potent in vitro anti-inflammatory activity.…”

Section: Discussionmentioning

confidence: 99%

“…28) In a recent study, the green and senescent leaves of this plant have been demonstrated to possess anti-inflammatory activity in an in vitro model. 29) Despite the emerging evidence for biological benefits of DP, the analgesic and anti-inflammatory activities of this plant and the underlying molecular mechanisms of its extracts have not been studied in detail.…”

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confidence: 99%

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Potent Anti-inflammatory and Analgesic Actions of the Chloroform Extract of <i>Dendropanax morbifera</i> Mediated by the Nrf2/HO-1 Pathway

Akram

Kim

et al. 2016

Biological & Pharmaceutical Bulletin

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Dendropanax morbifera LEVEILLE (DP) has been used in traditional Korean medicines to treat a variety of inflammatory diseases. Although the in vitro anti-inflammatory potential of this plant is understood, its in vivo efficacy and underlying molecular mechanism of anti-inflammatory effects are largely unknown. We elucidated the anti-inflammatory and analgesic activities and the underlying molecular mechanisms of DP using in vitro and in vivo models. Lipopolysaccharide (LPS)-stimulated murine macrophages were used to analyze the in vitro anti-inflammatory potential of DP extract and to elucidate the underlying mechanisms.In vivo animal models of phorbol 12-myristate 13-acetate (TPA)-induced ear edema and acetic acid-induced writhing response tests were used to analyze the in vivo anti-inflammatory effects and anti-nociceptive effects of DP extract, respectively. Methanolic extract of DP (DPME) significantly inhibited the release of nitric oxide (NO) and prostaglandin E 2 (PGE 2 ) in LPS-activated macrophages. Among the five sub-fractions, the chloroform fraction (DP-C) showed the most potent suppressive effects against pro-inflammatory mediators and cytokines in LPS-stimulated macrophages. These effects were attributed to inhibition of nuclear factor-κB (NF-κB) nuclear translocation and c-Jun N terminal kinase (JNK) 1/2 phosphorylation and to activation of NF-E2-related factor 2/heme oxygenase-1 (Nrf2/HO-1) signaling. DP-C exhibited strong protective in vivo effects in TPA-induced ear edema mouse model and acetic acid-induced writhing response test. Our data suggest that DP-C has potent anti-inflammatory and analgesic activities and may be a promising treatment against a variety of inflammatory diseases.

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Section: )contrasting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Potent Anti-inflammatory and Analgesic Actions of the Chloroform Extract of <i>Dendropanax morbifera</i> Mediated by the Nrf2/HO-1 Pathway

Akram

Kim

et al. 2016

Biological & Pharmaceutical Bulletin

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“…The antioxidant and anticancer activities of stem and leaf extracts [10], and the antidiabetic, anticomplement, antiatherogenic, hepatoprotective, and antiinflammatory activities [3,4,6,11,17] of leaf extracts of D. morbifera have been reported. Furthermore, the essential oil extracted from the flowers of this tree has been reported to have larvicidal effects against Aedes aegypti, the mosquito that acts as a vector of dengue fever [5].…”

Section: Introductionmentioning

confidence: 99%

“…Nevertheless, previous reports have mainly concentrated on crude aqueous or alcoholic extracts [3,10,14]. Some compounds have also been identified, including an antiinflammatory triterpenoid [20], an anticomplement polyacetylene [18], and antiinflammatory phenolics [11]. However, there is little information on the composition and biological activity of the volatile fraction of D. morbifera, although it has been reported that the essential oil from its leaves has antiatherogenic effects [4].…”

Section: Introductionmentioning

confidence: 99%

Volatile Compounds and Antiproliferative Effects of Dendropanax morbifera on HepG2 Cells

Yang¹,

Garcia²,

Lee³

2017

Journal of Life Science

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Dendropanax morbifera Lev. is known in Korea for its golden sap and medicinal properties. The many biological activities of the leaf and stem extracts suggest that this tree could be a valuable source of medicinal compounds for the treatment of various ailments such as dermatitis, migraines, dysmenorrhea, muscle pain, and infectious diseases. However, there is little information on the composition and biological activity of the volatile fraction of D. morbifera. Therefore, in this study, the volatile compounds in leaves, stems, and sap of D. morbifera were isolated using solvent and supercritical fluid extraction (SFE), and analyzed by gas chromatography/mass spectrometry to reveal their chemical composition and identify potential compounds of interest. Fifteen compounds were identified in the leaf extracts, whereas 29 and 3 compounds were identified in the stem and sap extracts, respectively. The volatile profiles obtained using solvent and SFE differed. Esters and aromatic hydrocarbons predominated in the solvent extract of leaves and SFE extract of stems, whereas the solvent extract of stems and SFE extract of leaves contained terpenoids. Limonene, α-pinene, and β-myrcene were identified in the volatile extract of sap, with limonene representing 96.30% of the total peak area. In addition, the antiproliferative effects of the solvent extracts of leaves and stems were evaluated, revealing that these solvent extracts were particularly effective in decreasing the proliferation of HepG2 cells.

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p‐Coumaric acid and its conjugates: dietary sources, pharmacokinetic properties and biological activities

et al. 2016

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p-Coumaric acid (4-hydroxycinnamic acid) is a phenolic acid that has low toxicity in mice (LD50 = 2850 mg kg(-1) body weight), serves as a precursor of other phenolic compounds, and exists either in free or conjugated form in plants. Conjugates of p-coumaric acid have been extensively studied in recent years due to their bioactivities. In this review, the occurrence, bioavailability and bioaccessibility of p-coumaric acid and its conjugates with mono-, oligo- and polysaccharides, alkyl alcohols, organic acids, amine and lignin are discussed. Their biological activities, including antioxidant, anti-cancer, antimicrobial, antivirus, anti-inflammatory, antiplatelet aggregation, anxiolytic, antipyretic, analgesic, and anti-arthritis activities, and their mitigatory effects against diabetes, obesity, hyperlipaemia and gout are compared. Cumulative evidence from multiple studies indicates that conjugation of p-coumaric acid greatly strengthens its biological activities; however, the high biological activity but low absorption of its conjugates remains a puzzle. © 2015 Society of Chemical Industry.

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Anti-inflammatory activity and phenolic composition of Dendropanax morbifera leaf extracts

Cited by 52 publications

References 43 publications

Potent Anti-inflammatory and Analgesic Actions of the Chloroform Extract of <i>Dendropanax morbifera</i> Mediated by the Nrf2/HO-1 Pathway

Potent Anti-inflammatory and Analgesic Actions of the Chloroform Extract of <i>Dendropanax morbifera</i> Mediated by the Nrf2/HO-1 Pathway

Volatile Compounds and Antiproliferative Effects of Dendropanax morbifera on HepG2 Cells

p‐Coumaric acid and its conjugates: dietary sources, pharmacokinetic properties and biological activities

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