Anti-inflammatory effects of Phaeodactylum tricornutum extracts on human blood mononuclear cells and murine macrophages

Neumann, Ulrike; Louis, Sandrine; Gille, Andrea; Derwenskus, Felix; Schmid‐Staiger, Ulrike; Briviba, Karlis; Bischoff, Stephan C.

doi:10.1007/s10811-017-1352-7

Cited by 33 publications

(33 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…CV and NO were spray-dried, whereas PT was bought as frozen wet biomass (10% w / v ) and freeze-dried subsequently (WKF L10, WKF, Darmstadt, Germany). Microalgae were protected from light and kept at −20 °C until they were ball milled as described by Neumann et al [ 24 ]. In short, microalgae were resuspended in water (10% w / v ) and disrupted using a laboratory ball-mill (PML 2, Buhler, Germany).…”

Section: Methodsmentioning

confidence: 99%

Bioavailability and Safety of Nutrients from the Microalgae Chlorella vulgaris, Nannochloropsis oceanica and Phaeodactylum tricornutum in C57BL/6 Mice

et al. 2018

Self Cite

View full text Add to dashboard Cite

Microalgae are rich in macronutrients and therefore, they have been proposed as a potential future food source preserving natural resources. Here, we studied safety and bioavailability of algae nutrients in mice. Three microalgae species, Chlorella vulgaris, Nannochloropsis oceanica and Phaeodactylum tricornutum, were studied after ball mill disruption at different doses (5%, 15% and 25% dry weight) for 14 days. In response to all three algae diets, we observed a weight gain similar or superior to that in response to the control diet. No substantial differences in organ weights nor gut length occurred. Protein bioavailability from the algae diets did not differ from the control diet ranging from 58% to 77% apparent biological value. Fat absorption was lower for microalgae compared to soy oil in control diets, albeit still substantial. High liver eicosapentaenoic acid levels were measured following feeding with N. oceanica, the algae richest in omega-3 fatty acids. Neither histological nor serum analyses revealed any heart, kidney or liver toxicity induced by any of the algae diets. Algae-rich diets were thus well accepted, well tolerated and suitable for the maintenance of body weight and normal organ function. No toxicological effects were observed.

show abstract

Section: Methodsmentioning

confidence: 99%

Bioavailability and Safety of Nutrients from the Microalgae Chlorella vulgaris, Nannochloropsis oceanica and Phaeodactylum tricornutum in C57BL/6 Mice

et al. 2018

Self Cite

View full text Add to dashboard Cite

show abstract

“…It has been reported that B[a]P is able to induce the expression of pro-inflammatory cytokines, notably in endothelial cells [53][54][55][56], and that some extracts of microalgae may have anti-inflammatory properties [57,58]. It was therefore decided to study the effects of B Regarding IL-1β mRNA expression, both microalgal extracts (0.1, 1 and 5 μg/mL) did not induce IL-1β mRNA expression compared with the control (Figure 4a,b).…”

Section: Effect Of P Tricornutum or O Tauri Extracts On Gene Expresmentioning

confidence: 99%

Protective Action of Ostreococcus Tauri and Phaeodactylum Tricornutum Extracts towards Benzo[a]Pyrene-Induced Cytotoxicity in Endothelial Cells

Goff

Delbrut²,

Quinton³

et al. 2019

Marine Drugs

View full text Add to dashboard Cite

Marine microalgae are known to be a source of bioactive molecules of interest to human health, such as n-3 polyunsaturated fatty acids (n-3 PUFAs) and carotenoids. The fact that some of these natural compounds are known to exhibit anti-inflammatory, antioxidant, anti-proliferative, and apoptosis-inducing effects, demonstrates their potential use in preventing cancers and cardiovascular diseases (CVDs). Benzo[a]pyrene (B[a]P), a polycyclic aromatic hydrocarbon (PAH), is an ubiquitous environmental pollutant known to contribute to the development or aggravation of human diseases, such as cancer, CVDs, and immune dysfunction. Most of these deleterious effects are related to the activation of the polycyclic aromatic hydrocarbon receptor (AhR). In this context, two ethanolic microalgal extracts with concentrations of 0.1 to 5 µg/mL are tested, Ostreoccoccus tauri (OT) and Phaeodactylum tricornutum (PT), in order to evaluate and compare their potential effects towards B[a]P-induced toxicity in endothelial HMEC-1 cells. Our results indicate that the OT extract can influence the toxicity of B[a]P. Indeed, apoptosis and the production of extracellular vesicles were decreased, likely through the reduction of the expression of CYP1A1, a B[a]P bioactivation enzyme. Furthermore, the B[a]P-induced expression of the inflammatory cytokines IL-8 and IL1-β was reduced. The PT extract only inhibited the expression of the B[a]P-induced cytokine IL-8 expression. The OT extract therefore seems to be a good candidate for counteracting the B[a]P toxicity.

show abstract

“…Fucoxanthin has a unique structure compared to other carotenoids like beta-carotene due to its allenic bond, conjugated carbonyl group, 5,6-monoepoxideand carbonyl group. Because of its structure, fucoxanthin has anti-inflammatory, anti-carcinogenic, anti-obesity and anti-diabetic properties [12,[16][17][18][19][20][21]. Therefore, fucoxanthin is supposed to prevent and alleviate several chronic diseases.…”

Section: Introductionmentioning

confidence: 99%

Coproduction of EPA and Fucoxanthin with P. tricornutum – A Promising Approach for Up‐ and Downstream Processing

Derwenskus

Schafer

Müller

et al. 2020

Chemie Ingenieur Technik

Self Cite

View full text Add to dashboard Cite

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. Eicosapentaenoic acid (EPA) and fucoxanthin, a carotenoid, provide a broad variety of health benefits in human nutrition. In this study, an up-and downstream process for the coproduction of EPA and fucoxanthin using the diatom Phaeodactylum tricornutum in flat-panel airlift photobioreactors is proposed. The approach represents a promising alternative to conventional sources for both compounds, viz. marine fish and macroalgae. The productivity as well as the biomass-specific product content were optimized during cultivation. Subsequently, both compounds were extracted, separated and purified using pressurized liquids.

show abstract

Anti-inflammatory effects of Phaeodactylum tricornutum extracts on human blood mononuclear cells and murine macrophages

Cited by 33 publications

References 45 publications

Bioavailability and Safety of Nutrients from the Microalgae Chlorella vulgaris, Nannochloropsis oceanica and Phaeodactylum tricornutum in C57BL/6 Mice

Bioavailability and Safety of Nutrients from the Microalgae Chlorella vulgaris, Nannochloropsis oceanica and Phaeodactylum tricornutum in C57BL/6 Mice

Protective Action of Ostreococcus Tauri and Phaeodactylum Tricornutum Extracts towards Benzo[a]Pyrene-Induced Cytotoxicity in Endothelial Cells

Coproduction of EPA and Fucoxanthin with P. tricornutum – A Promising Approach for Up‐ and Downstream Processing

Contact Info

Product

Resources

About