Anti-inflammatory effects of orally administered glucosamine oligomer in an experimental model of inflammatory bowel disease

Aso, Kazuo; Osaki, Tomohiro; Kurozumi, Seizi; Kiyose, Masatoshi; Tsuka, Takeshi; Murahata, Yusuke; Imagawa, Tomohiro; Itoh, Norihiko; Minami, Saburo; Sato, Kimihiko; Okamoto, Yoshiharu

doi:10.1016/j.carbpol.2014.09.012

Cited by 67 publications

(34 citation statements)

References 34 publications

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“…In the cardiovascular system, O-GlcNAc modulates cardiac and vascular contractility and remodeling as well as inflammation-related processes (da Costa et al, 2018;Kronlage et al, 2019). Glucosamine, which increases O-GlcNAc-modified proteins, reduces the levels of circulating pro-inflammatory cytokines, including TNF-α and IL-6 (Azuma et al, 2015) and attenuates LPS-induced activation of NF-κB in RAW264.7 macrophages (Shin et al, 2013). Glucosamine also reduces vascular expression of pro-inflammatory mediators, inhibiting acute inflammatory responses and neointimal layer formation following balloon catheter injury of the carotid artery in ovariectomized rats (Xing et al, 2008), indicating that O-GlcNAc has anti-inflammatory and vasoprotective actions.…”

Section: Introductionmentioning

confidence: 99%

Acute Increase in O-GlcNAc Improves Survival in Mice With LPS-Induced Systemic Inflammatory Response Syndrome

et al. 2020

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Section: Introductionmentioning

confidence: 99%

Acute Increase in O-GlcNAc Improves Survival in Mice With LPS-Induced Systemic Inflammatory Response Syndrome

et al. 2020

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“…Derived from the hydrolysis of chitosan, the chitooligosaccharides have several biofunctional properties, including antiinflammatory , prebiotic , antimicrobial , antitumor , and immunopotentiating effects . Therefore, the nutraceutical and medical industries have given special attention to the production of oligosaccharides from chitosan .…”

Section: Introductionmentioning

confidence: 99%

Recovery and purification of chitosanase produced by Bacillus cereus using expanded bed adsorption and central composite design

Araújo

Pimentel

Silva

et al. 2016

J of Separation Science

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This study presents a system for expanded bed adsorption for the purification of chitosanase from broth extract in a single step. A chitosanase-producing strain was isolated and identified as Bacillus cereus C-01 and used to produce chitosanases. The expanded bed adsorption conditions for chitosanase purification were optimized statistically using STREAMLINE(TM) DEAE and a homemade column (2.6 × 30.0 cm). Dependent variables were defined by the quality criteria purification factor (P) and enzyme yield to optimize the chromatographic process. Statistical analyses showed that the optimum conditions for the maximum P were 150 cm/h load flow velocity, 6.0 cm settled bed height, and 7.36 cm distributor height. Distributor height had a strong influence on the process, considerably affecting both the P and enzyme yield. Optimizing the purification variables resulted in an approximately 3.66-fold increase in the P compared with the value under nonoptimized conditions. This system is promising for the recovery of chitosanase from B. cereus C-01 and is economically viable because it promotes the reduction steps.

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“…A recent report showed similar suppressive effects on the levels of serum tumor necrosis factor-α (TNF-α), IL-6 concentrations, serum IL-10, transforming growth factor-β, and IL-2 thorough oral administration of GlcNAc and GlcN in an experimental of rheumatoid arthritis model (Azuma et al, 2012). Moreover, oral administration of Shahidi et al Utilization of marine by-products for the recovery of value-added products COS inhibited colon shortening and tissue injury by suppressing myeloperoxidase activation in inflammatory cells, reducing serum levels of pro-inflammatory cytokines tumor necrosis factor-α and IL-6, and prolonged survival time, as well as inhibiting the activation of nuclear factor-kappa B, cyclooxygenase-2, and inducible nitric oxide synthase, in mice IBD (inflammatory bowel disease) model (Azuma et al, 2015c). Due to the inconsistent clinical data, difficulties in producing a structurally consistent product, the requirement of relatively high dosages for efficacy, and competition from fiber products with FDA health claims such as oats, bran, psyllium fiber, soy protein and phytosterol esters, chitosan is not widely used as a functional ingredient in North America (Hayes et al, 2008a).…”

Section: Application In Functional Foods/nutraceuticalmentioning

confidence: 99%

Utilization of marine by-products for the recovery of value-added products

Shahidi¹,

Varatharajan²,

Han³

et al. 2019

JFB

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The world fisheries resources have exceeded 160 million tons in recent years. However, every year a considerable amount of total catch is discarded as by-catch or as processing leftovers, and that includes trimmings, fins, frames, heads, skin, viscera and among others. In addition, a large quantity of processing by-products is accumulated as shells of crustaceans and shellfish from marine bioprocessing plants. Recognition of the limited marine resources and the increasing environmental pollution has emphasized the need for better utilization of the by-products. Marine by-products contain valuable protein and lipid fractions, minerals, enzymes as well as many other components. The major fraction of by-products are used for feed production—in making fish meal/oil, but this has low profitability. However, there are many ways in which the fish and shellfish waste could be better utilized, including the production of novel food ingredients, nutraceuticals, pharmaceuticals, biomedical materials, fine chemicals, and other value-added products. In recent times, much research is conducted in order to explore the possible uses of different by-products. This contribution primarily covers the characteristics and utilization of the main ingredients such as protein, lipid, chitin and its derivatives, enzymes, carotenoids, and minerals originating from marine by-products.

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Anti-inflammatory effects of orally administered glucosamine oligomer in an experimental model of inflammatory bowel disease

Cited by 67 publications

References 34 publications

Acute Increase in O-GlcNAc Improves Survival in Mice With LPS-Induced Systemic Inflammatory Response Syndrome

Acute Increase in O-GlcNAc Improves Survival in Mice With LPS-Induced Systemic Inflammatory Response Syndrome

Recovery and purification of chitosanase produced by Bacillus cereus using expanded bed adsorption and central composite design

Utilization of marine by-products for the recovery of value-added products

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