Anti-inflammatory effects of <i>Saururus chinensis</i> aerial parts in murine macrophages via induction of heme oxygenase-1

Xue, Meng; Kim, Inhye; Jeong, Yong Seok; Cho, Young Mi; Kang, Se Chan

doi:10.1177/1535370215614657

Cited by 14 publications

(6 citation statements)

References 40 publications

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“…Recently, Meng et al reported that anti-inflammatory effects of Saururus chinensis Baill. in murine macrophages regulating heme oxygenase-1 [36]. Moreover, various reports revealed that Saururus chinensis Baill.…”

Section: Discussionmentioning

confidence: 99%

Effect of Saururus chinensis leaves extract on type II collagen-induced arthritis mouse model

Nho

Lee

Jung

et al. 2019

BMC Complement Altern Med

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BackgroundSaururus chinensis leaves have been used as traditional medicine in Korea for pain, intoxication, edema, and furuncle. According to previous reports, these leaves exert renoprotective, neuroprotective, and antioxidant effects by attenuating inflammatory responses. However, the beneficial effect of Saururus chinensis leaves on arthritis has not been elucidated. Thus, we evaluated the water extract of Saururus chinensis leaves (SHW) using type II collagen-induced arthritis (CIA) mice models.MethodsQuantitative analysis of major components from SHW was performed by HPLC. Arthritis was induced by injection of type II collagen. Each group was orally administered SHW (100 mg/kg and 500 mg/kg). Methotrexate (MTX) was used as a positive control. Serum levels of interleukin-6, TNF-alpha, and type II collagen IgG in the animal models were measured using ELISA. Histological features were observed by H&E staining.ResultsQuantitative analysis of SHW showed the contents as 56.4 ± 0.52 mg/g of miquelianin, 7.75 ± 0.08 mg/g of quercetin 3-O-(2”-O-β -glucopyranosyl)-α-rhamnopyranoside, and 3.17 ± 0.02 mg/g of quercitrin. Treatment with 500 mg/kg SHW decreased the serum level of Interleukin-6 (IL-6), TNF-alpha, and collagen IgG in the CIA model. Moreover, SHW treatment diminished the swelling of hind limbs and monocyte infiltration in blood vessels in CIA animal models. The results indicate that SHW could decrease CIA-induced arthritis in vivo.ConclusionsThe results indicate that SHW could be used to improving arthritis by reducing inflammatory factors (IL-6 and TNF-alpha). However, further experiments are required to determine how SHW influences signal transduction in animal models.Electronic supplementary materialThe online version of this article (10.1186/s12906-018-2418-z) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Effect of Saururus chinensis leaves extract on type II collagen-induced arthritis mouse model

Nho

Lee

Jung

et al. 2019

BMC Complement Altern Med

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“…To date, a variety of HO-1 activator can be extracted from Saururus chinensis [ 54 , 55 ], Phytolacca esculenta [ 68 ], Garlic [ 40 ], and soshiho-tang [ 73 ]. Among them, diallyl-disulfide (isolated from Garlic ) [ 40 ] and esculentoside A (isolated from Phytolacca esculenta ) [ 68 ] have been further proved as Nrf-2 activators.…”

Section: Basic Researchesmentioning

confidence: 99%

“…Saururus chinensis (SC) is an effective antioxidant. Three of its extracts (saucerneol D [ 54 ], a subfraction of its ethanol extract, and sauchinone [ 55 ]) showed similar effect of antioxidant through upregulating the expression of HO-1. Among them sauchinone also suppressed GATA-3 activity [ 56 ].…”

Section: Basic Researchesmentioning

confidence: 99%

Herbal Medicines for Asthmatic Inflammation: From Basic Researches to Clinical Applications

Liu

Xuan

Ying

et al. 2016

Mediators of Inflammation

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Asthma is one of the most common chronic inflammatory disorders, associated with reversible airflow obstruction, airway hyperresponsiveness, and airway remodeling. This disease has a significant impact on individuals, their families, and society. Standardized therapeutics such as inhaled corticosteroid in combination with long acting β2 agonist have been applied for asthma control; however, complementary and alternative medicines, especially herbal medicines, are still widely used all over the world. A growing body of literature suggests that various herbals or related products might be effective in inhibiting asthmatic inflammation. In this review, we summarize recent advances about the mechanistic studies of herbal medicines on allergic airway inflammation in animal models and their potential application into clinic for asthma control.

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“…삼백초 (삼백초, Saururus chinensis Baill)는 후추목 삼백초과에 속하는 다년생 초본으로 습지에서 잘 자라며 (Kim et al, 2019), 꽃이 필 무렵 윗부분 잎 2 -3개가 백색을 띠고 뿌리와 꽃도 백색을 띠므로 삼백초라 일컬어 진다 (Meng et al, 2016).…”

Section: Introductionunclassified

Effect of Mixed Organic Fertilizer on Growth, Yield and Component Content of Saururus chinensis Baill in Paddy Field Cultivation

Kim¹,

Kim

Youn

et al. 2021

Korean J. Soil. Sci. Fert.

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This study was conducted to examine the effect of mixed organic fertilizer (MOF) application on the growth, yield, soil chemistry change, and bio-active component of Saururus chinensis Baill in paddy cultivation under organic cultivation practice. Saururus chinensis Baill were cultivated with five levels of MOF application including 50% treatment based on the nitrogen content of the soil test fertilization recommendation. The plant length increased with the increased MOF application, and the fresh weight of the above-ground part was the highest in the 100% MOF treatment and the rhizome was the highest in the 125% MOF treatment. Among soil chemistry, pH was lowered, and available phosphorus increased as the MOF application rate increased. Phosphorus and potassium contents in the leaves increased with the MOF rate. The bio-active component (quercetin) in the leaves also increased proportionally with the MOF rate, In the rhizome, the content of quercitrin showed an opposite pattern to the above-ground part. The MOF for obtaining the highest yield of Saururus chinensis Baill were 100% MOF for the above-ground part and 150% MOF for the rhizome.

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Anti-inflammatory effects of Saururus chinensis aerial parts in murine macrophages via induction of heme oxygenase-1

Cited by 14 publications

References 40 publications

Effect of Saururus chinensis leaves extract on type II collagen-induced arthritis mouse model

Effect of Saururus chinensis leaves extract on type II collagen-induced arthritis mouse model

Herbal Medicines for Asthmatic Inflammation: From Basic Researches to Clinical Applications

Effect of Mixed Organic Fertilizer on Growth, Yield and Component Content of Saururus chinensis Baill in Paddy Field Cultivation

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